Showing Protein Radical S-adenosyl methionine domain-containing protein 2 (CDBP03876)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 compounds
Identification
HMDB Protein ID CDBP03876
Secondary Accession Numbers Not Available
Name Radical S-adenosyl methionine domain-containing protein 2
Description Not Available
Synonyms
  1. Cytomegalovirus-induced gene 5 protein
  2. Viperin
  3. Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible
Gene Name RSAD2
Protein Type Enzyme
Biological Properties
General Function Involved in catalytic activity
Specific Function Involved in antiviral defense. May impair virus budding by disrupting lipid rafts at the plasma membrane, a feature which is essential for the budding process of many viruses. Acts through binding with and inactivating FPPS, an enzyme involved in synthesis of cholesterol, farnesylated and geranylated proteins, ubiquinones dolichol and heme. Plays a major role in the cell antiviral state induced by type I and type II interferon. Displays antiviral effect against HIV-1 virus, hepatitis C virus, human cytomegalovirus, and aphaviruses, but not vesiculovirus
GO Classification
Function
binding
catalytic activity
metal cluster binding
iron-sulfur cluster binding
Cellular Location
  1. Peripheral membrane protein
  2. Endoplasmic reticulum membrane
  3. Cytoplasmic side
  4. Golgi apparatus
Pathways
Gene Properties
Chromosome Location Chromosome:2
Locus 2p25.2
SNPs RSAD2
Gene Sequence 
>1086 bp
ATGTGGGTGCTTACACCTGCTGCTTTTGCTGGGAAGCTCTTGAGTGTGTTCAGGCAACCT
CTGAGCTCTCTGTGGAGGAGCCTGGTCCCGCTGTTCTGCTGGCTGAGGGCAACCTTCTGG
CTGCTAGCTACCAAGAGGAGAAAGCAGCAGCTGGTCCTGAGAGGGCCAGATGAGACCAAA
GAGGAGGAAGAGGACCCTCCTCTGCCCACCACCCCAACCAGCGTCAACTATCACTTCACT
CGCCAGTGCAACTACAAATGCGGCTTCTGTTTCCACACAGCCAAAACATCCTTTGTGCTG
CCCCTTGAGGAAGCAAAGAGAGGATTGCTTTTGCTTAAGGAAGCTGGTATGGAGAAGATC
AACTTTTCAGGTGGAGAGCCATTTCTTCAAGACCGGGGAGAATACCTGGGCAAGTTGGTG
AGGTTCTGCAAAGTAGAGTTGCGGCTGCCCAGCGTGAGCATCGTGAGCAATGGAAGCCTG
ATCCGGGAGAGGTGGTTCCAGAATTATGGTGAGTATTTGGACATTCTCGCTATCTCCTGT
GACAGCTTTGACGAGGAAGTCAATGTCCTTATTGGCCGTGGCCAAGGAAAGAAGAACCAT
GTGGAAAACCTTCAAAAGCTGAGGAGGTGGTGTAGGGATTATAGAGTCGCTTTCAAGATA
AATTCTGTCATTAATCGTTTCAACGTGGAAGAGGACATGACGGAACAGATCAAAGCACTA
AACCCTGTCCGCTGGAAAGTGTTCCAGTGCCTCTTAATTGAGGGTGAGAATTGTGGAGAA
GATGCTCTAAGAGAAGCAGAAAGATTTGTTATTGGTGATGAAGAATTTGAAAGATTCTTG
GAGCGCCACAAAGAAGTGTCCTGCTTGGTGCCTGAATCTAACCAGAAGATGAAAGACTCC
TACCTTATTCTGGATGAATATATGCGCTTTCTGAACTGTAGAAAGGGACGGAAGGACCCT
TCCAAGTCCATCCTGGATGTTGGTGTAGAAGAAGCTATAAAATTCAGTGGATTTGATGAA
AAGATGTTTCTGAAGCGAGGAGGAAAATACATATGGAGTAAGGCTGATCTGAAGCTGGAT
TGGTAG
Protein Properties
Number of Residues 361
Molecular Weight 42169.3
Theoretical pI 8.33
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Radical S-adenosyl methionine domain-containing protein 2
MWVLTPAAFAGKLLSVFRQPLSSLWRSLVPLFCWLRATFWLLATKRRKQQLVLRGPDETK
EEEEDPPLPTTPTSVNYHFTRQCNYKCGFCFHTAKTSFVLPLEEAKRGLLLLKEAGMEKI
NFSGGEPFLQDRGEYLGKLVRFCKVELRLPSVSIVSNGSLIRERWFQNYGEYLDILAISC
DSFDEEVNVLIGRGQGKKNHVENLQKLRRWCRDYRVAFKINSVINRFNVEEDMTEQIKAL
NPVRWKVFQCLLIEGENCGEDALREAERFVIGDEEFERFLERHKEVSCLVPESNQKMKDS
YLILDEYMRFLNCRKGRKDPSKSILDVGVEEAIKFSGFDEKMFLKRGGKYIWSKADLKLD
W
GenBank ID Protein 62822253
UniProtKB/Swiss-Prot ID Q8WXG1
UniProtKB/Swiss-Prot Entry Name RSAD2_HUMAN
PDB IDs Not Available
GenBank Gene ID AC017076
GeneCard ID RSAD2
GenAtlas ID RSAD2
HGNC ID HGNC:30908
References
General References Not Available