| Identification |
|---|
| HMDB Protein ID
| CDBP03873 |
| Secondary Accession Numbers
| Not Available |
| Name
| Nuclear respiratory factor 1 |
| Description
| Not Available |
| Synonyms
|
- Alpha palindromic-binding protein
- Alpha-pal
- NRF-1
|
| Gene Name
| NRF1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in DNA binding |
| Specific Function
| Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:7 |
| Locus
| 7q32 |
| SNPs
| NRF1 |
| Gene Sequence
|
>1512 bp
ATGGAGGAACACGGAGTGACCCAAACCGAACATATGGCTACCATAGAAGCACATGCAGTG
GCCCAGCAAGTGCAGCAGGTCCATGTGGCTACTTACACCGAGCATAGTATGCTGAGTGCT
GATGAAGACTCGCCTTCTTCGCCCGAGGACACCTCTTACGATGACTCAGATATACTCAAC
TCCACAGCAGCTGATGAGGTGACAGCTCATCTGGCAGCTGCAGGTCCTGTGGGAATGGCC
GCTGCTGCTGCTGTGGCAACAGGAAAGAAACGGAAACGGCCTCATGTATTTGAGTCTAAT
CCATCTATCCGGAAGAGGCAACAAACACGTTTGCTTCGGAAACTTCGAGCCACGTTAGAT
GAATATACTACTCGTGTGGGACAGCAAGCTATTGTCCTCTGTATCTCACCCTCCAAACCT
AACCCTGTCTTTAAAGTGTTTGGTGCAGCACCTTTGGAGAATGTGGTGCGTAAGTACAAG
AGCATGATCCTGGAAGACCTGGAGTCTGCTCTGGCAGAACACGCCCCTGCGCCACAGGAG
GTTAACTCAGAACTGCCGCCTCTCACCATCGACGGAATTCCAGTCTCTGTGGACAAAATG
ACCCAGGCCCAGCTTCGGGCATTTATCCCAGAGATGCTCAAGTACTCTACAGGTCGGGGA
AAACCAGGCTGGGGGAAAGAAAGCTGCAAGCCCATCTGGTGGCCTGAAGATATCCCCTGG
GCAAATGTCCGGAGTGATGTCCGCACAGAAGAGCAAAAGCAGAGGGTTTCATGGACCCAG
GCACTACGGACCATAGTTAAAAACTGTTATAAACAGCATGGGCGGGAAGACCTTTTGTAT
GCCTTTGAAGATCAGCAAACGCAAACACAGGCCACAGCCACACATAGTATAGCTCATCTT
GTACCATCACAGACTGTAGTCCAGACTTTTAGTAACCCTGATGGCACTGTCTCACTTATC
CAGGTTGGTACGGGGGCAACAGTAGCCACATTGGCTGATGCTTCAGAATTGCCAACCACG
GTCACCGTTGCCCAAGTGAATTATTCTGCCGTGGCTGATGGAGAGGTGGAACAAAATTGG
GCCACGTTACAGGGAGGTGAGATGACCATCCAGACGACGCAAGCATCAGAGGCCACCCAG
GCGGTGGCATCGTTGGCAGAGGCCGCAGTGGCAGCTTCTCAGGAGATGCAGCAGGGAGCT
ACAGTCACTATGGCGCTTAACAGCGAAGCTGCCGCCCATGCTGTCGCCACCCTGGCTGAG
GCCACCTTACAAGGTGGGGGACAGATCGTCTTGTCTGGGGAAACCGCAGCAGCCGTCGGA
GCACTTACTGGAGTCCAAGATGCTAATGGCCTGGTCCAGATCCCTGTGAGCATGTACCAG
ACTGTGGTGACCAGCCTCGCCCAGGGCAACGGACCAGTGCAGGTGGCCATGGCCCCTGTG
ACCACCAGGATATCAGACAGCGCAGTCACCATGGACGGCCAAGCTGTGGAGGTGGTGACA
TTGGAACAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 503 |
| Molecular Weight
| 53540.7 |
| Theoretical pI
| 4.69 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Nuclear respiratory factor 1
MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSADEDSPSSPEDTSYDDSDILN
STAADEVTAHLAAAGPVGMAAAAAVATGKKRKRPHVFESNPSIRKRQQTRLLRKLRATLD
EYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLENVVRKYKSMILEDLESALAEHAPAPQE
VNSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPW
ANVRSDVRTEEQKQRVSWTQALRTIVKNCYKQHGREDLLYAFEDQQTQTQATATHSIAHL
VPSQTVVQTFSNPDGTVSLIQVGTGATVATLADASELPTTVTVAQVNYSAVADGEVEQNW
ATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQQGATVTMALNSEAAAHAVATLAE
ATLQGGGQIVLSGETAAAVGALTGVQDANGLVQIPVSMYQTVVTSLAQGNGPVQVAMAPV
TTRISDSAVTMDGQAVEVVTLEQ
|
| External Links |
|---|
| GenBank ID Protein
| 347960 |
| UniProtKB/Swiss-Prot ID
| Q16656 |
| UniProtKB/Swiss-Prot Entry Name
| NRF1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| L22454 |
| GeneCard ID
| NRF1 |
| GenAtlas ID
| NRF1 |
| HGNC ID
| HGNC:7996 |
| References |
|---|
| General References
| Not Available |