| Identification |
|---|
| HMDB Protein ID
| CDBP03831 |
| Secondary Accession Numbers
| Not Available |
| Name
| Exportin-5 |
| Description
| Not Available |
| Synonyms
|
- Exp5
- Ran-binding protein 21
|
| Gene Name
| XPO5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Mediates the nuclear export of micro-RNA precursors, which form short hairpins. Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference, and adenovirus VA1 dsRNA. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5'-overhang in a sequence- independent manner, have only a short 3'-overhang, and that have a double-stranded length of at least 15 base-pairs. Binding is dependent on Ran-GTP |
| GO Classification
|
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6p21.1 |
| SNPs
| XPO5 |
| Gene Sequence
|
>3615 bp
ATGGCGATGGATCAAGTAAACGCGCTGTGCGAGCAGCTGGTGAAAGCGGTGACGGTCATG
ATGGACCCCAACTCCACCCAGCGCTACCGGCTGGAAGCCCTCAAGTTTTGTGAGGAGTTT
AAAGAAAAGTGTCCTATCTGTGTCCCCTGTGGCTTGAGGTTGGCTGAGAAAACACAAGTT
GCCATCGTCAGACATTTTGGCCTTCAGATCCTGGAACACGTTGTCAAGTTTCGGTGGAAC
GGCATGTCTCGATTGGAGAAGGTGTATCTGAAGAACAGTGTCATGGAGCTGATTGCAAAT
GGAACATTGAACATTTTGGAAGAGGAGAACCATATTAAAGATGCTCTGTCTCGAATTGTA
GTGGAAATGATCAAGCGAGAGTGGCCACAGCATTGGCCTGACATGCTAATAGAATTGGAC
ACTCTTTCCAAACAAGGGGAAACACAGACAGAATTGGTGATGTTTATCCTTTTGCGACTG
GCAGAGGATGTAGTGACTTTTCAGACACTTCCCCCTCAAAGAAGAAGGGACATCCAGCAA
ACATTAACCCAGAACATGGAAAGGATCTTCAGTTTTCTGCTTAACACACTTCAAGAAAAT
GTAAACAAGTATCAGCAAGTGAAGACAGATACTTCTCAGGAGTCAAAGGCGCAAGCAAAC
TGTCGAGTAGGAGTTGCAGCACTGAATACTCTAGCAGGCTATATTGACTGGGTGTCTATG
AGTCACATCACTGCTGAAAACTGTAAACTCCTGGAGATACTGTGTTTGCTGTTGAATGAA
CAGGAACTTCAGTTGGGAGCCGCTGAGTGTCTTCTCATTGCAGTCAGCAGAAAAGGCAAG
TTGGAAGACCGGAAGCCCTTGATGGTCTTATTTGGAGATGTTGCCATGCATTATATACTC
TCCGCCGCACAGACTGCTGATGGAGGAGGTTTGGTAGAAAAACACTACGTCTTTCTGAAG
AGGCTCTGTCAGGTGTTGTGTGCGCTGGGCAATCAGCTGTGTGCATTGCTGGGTGCAGAT
TCTGATGTAGAAACACCATCAAACTTTGGAAAATACCTGGAATCTTTTCTTGCTTTCACA
ACCCATCCAAGTCAGTTTCTACGCTCTTCAACTCAGATGACTTGGGGAGCCCTCTTCAGG
CATGAAATCCTGTCCCGTGATCCTTTGCTATTAGCAATAATACCAAAATATCTTCGTGCT
TCCATGACTAACTTGGTCAAGATGGGCTTTCCTTCTAAAACAGACAGCCCTAGCTGTGAA
TATTCTCGGTTTGATTTTGATAGCGATGAGGACTTCAATGCTTTCTTCAACTCCTCCCGA
GCACAACAAGGAGAGGTGATGAGGTTGGCATGTCGTTTGGATCCCAAAACTAGCTTCCAG
ATGGCTGGGGAGTGGCTAAAGTATCAACTATCAACTTTTCTTGATGCTGGTTCTGTGAAT
TCTTGTTCTGCAGTTGGAACTGGAGAAGGAAGCCTCTGTTCCGTCTTCTCACCTTCATTC
GTGCAGTGGGAAGCCATGACTCTTTTTTTGGAAAGTGTTATCACCCAGATGTTTCGAACA
CTAAATAGAGAAGAAATTCCTGTTAATGATGGAATAGAGCTATTGCAGATGGTTCTGAAC
TTTGATACCAAGGATCCCCTCATCCTGTCCTGCGTCCTTACTAATGTCTCTGCACTCTTT
CCATTTGTCACCTACAGACCAGAGTTCCTGCCCCAGGTCTTCTCTAAGCTATTTTCATCT
GTCACTTTTGAAACTGTTGAAGAAAGTAAGGCCCCCAGAACCCGGGCAGTGAGGAATGTG
AGGAGGCATGCTTGTTCCTCCATCATCAAGATGTGTCGTGACTACCCCCAGCTTGTGCTG
CCCAATTTTGACATGCTTTATAACCATGTGAAGCAACTCCTCTCCAATGAGCTACTCCTG
ACACAAATGGAGAAGTGTGCCCTCATGGAAGCCCTGGTTCTCATTAGCAACCAATTTAAG
AACTACGAGCGTCAGAAGGTGTTCCTAGAGGAGCTGATGGCACCAGTGGCCAGCATCTGG
CTTTCTCAAGACATGCACAGAGTGCTGTCAGATGTTGATGCTTTCATTGCGTATGTGGGT
ACAGATCAGAAGAGCTGTGACCCAGGCCTGGAGGATCCGTGTGGCTTAAACCGTGCACGA
ATGAGCTTTTGTGTATACAGCATTCTGGGTGTGGTGAAACGAACTTGCTGGCCCACTGAC
CTAGAAGAGGCCAAAGCTGGGGGATTTGTGGTGGGTTATACATCCAGTGGAAATCCAATC
TTCCGTAACCCCTGCACAGAGCAGATTCTGAAACTTCTTGACAATTTGCTTGCGCTTATA
AGAACCCACAATACATTATATGCACCAGAAATGCTAGCCAAAATGGCAGAGCCTTTCACC
AAGGCTCTGGATATGCTTGACGCGGAAAAATCTGCTATATTAGGATTACCTCAACCTCTC
TTGGAACTCAATGACTCTCCTGTCTTCAAAACCGTCTTGGAAAGAATGCAGCGTTTCTTC
TCTACCCTCTATGAAAACTGTTTTCATATCCTAGGGAAGGCAGGCCCTTCCATGCAGCAA
GACTTCTATACTGTGGAGGACCTTGCTACCCAGCTTCTCAGCTCAGCCTTTGTCAACTTG
AACAATATTCCTGACTACCGACTCAGACCCATGCTTCGTGTCTTTGTAAAGCCTCTGGTG
CTCTTCTGTCCCCCAGAGCACTATGAAGCCCTGGTATCCCCCATCCTCGGACCTCTTTTC
ACCTACCTCCATATGAGGCTTTCTCAGAAATGGCAAGTTATCAACCAAAGGAGCCTGCTG
TGTGGAGAAGATGAGGCTGCAGATGAAAACCCAGAGTCTCAAGAGATGCTGGAGGAGCAA
CTGGTGAGGATGTTAACCCGAGAAGTCATGGACCTAATCACGGTTTGCTGTGTTTCAAAG
AAGGGTGCTGACCACAGTAGTGCTCCCCCAGCAGATGGAGACGATGAAGAAATGATGGCC
ACAGAGGTCACCCCCTCAGCTATGGCAGAGCTTACAGACCTGGGCAAATGTCTGATGAAG
CATGAGGATGTTTGTACAGCGCTATTAATTACAGCCTTCAATTCCCTGGCCTGGAAAGAT
ACTCTGTCCTGCCAGAGGACAACCTCACAGCTCTGCTGGCCTCTCCTCAAACAAGTGCTG
TCAGGGACACTGCTCGCAGATGCAGTTACGTGGCTTTTCACCAGTGTGCTGAAAGGCTTA
CAGATGCACGGGCAGCACGACGGGTGCATGGCTTCCCTGGTCCATCTGGCCTTCCAGATA
TACGAGGCACTGCGCCCCAGGTACCTGGAGATAAGAGCTGTAATGGAGCAAATCCCTGAA
ATACAGAAGGACTCACTGGACCAGTTTGACTGCAAGCTTTTAAACCCCTCCCTGCAGAAA
GTGGCTGACAAGCGCCGAAAGGACCAATTCAAACGCCTCATTGCTGGTTGCATTGGGAAA
CCCTTGGGAGAGCAGTTCCGAAAAGAAGTTCACATTAAGAATCTTCCCTCACTTTTCAAA
AAAACAAAGCCAATGCTGGAGACGGAGGTGCTGGACAATGATGGGGGTGGCCTGGCCACC
ATCTTTGAACCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1204 |
| Molecular Weight
| 136309.9 |
| Theoretical pI
| 5.55 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Exportin-5
MAMDQVNALCEQLVKAVTVMMDPNSTQRYRLEALKFCEEFKEKCPICVPCGLRLAEKTQV
AIVRHFGLQILEHVVKFRWNGMSRLEKVYLKNSVMELIANGTLNILEEENHIKDALSRIV
VEMIKREWPQHWPDMLIELDTLSKQGETQTELVMFILLRLAEDVVTFQTLPPQRRRDIQQ
TLTQNMERIFSFLLNTLQENVNKYQQVKTDTSQESKAQANCRVGVAALNTLAGYIDWVSM
SHITAENCKLLEILCLLLNEQELQLGAAECLLIAVSRKGKLEDRKPLMVLFGDVAMHYIL
SAAQTADGGGLVEKHYVFLKRLCQVLCALGNQLCALLGADSDVETPSNFGKYLESFLAFT
THPSQFLRSSTQMTWGALFRHEILSRDPLLLAIIPKYLRASMTNLVKMGFPSKTDSPSCE
YSRFDFDSDEDFNAFFNSSRAQQGEVMRLACRLDPKTSFQMAGEWLKYQLSTFLDAGSVN
SCSAVGTGEGSLCSVFSPSFVQWEAMTLFLESVITQMFRTLNREEIPVNDGIELLQMVLN
FDTKDPLILSCVLTNVSALFPFVTYRPEFLPQVFSKLFSSVTFETVEESKAPRTRAVRNV
RRHACSSIIKMCRDYPQLVLPNFDMLYNHVKQLLSNELLLTQMEKCALMEALVLISNQFK
NYERQKVFLEELMAPVASIWLSQDMHRVLSDVDAFIAYVGTDQKSCDPGLEDPCGLNRAR
MSFCVYSILGVVKRTCWPTDLEEAKAGGFVVGYTSSGNPIFRNPCTEQILKLLDNLLALI
RTHNTLYAPEMLAKMAEPFTKALDMLDAEKSAILGLPQPLLELNDSPVFKTVLERMQRFF
STLYENCFHILGKAGPSMQQDFYTVEDLATQLLSSAFVNLNNIPDYRLRPMLRVFVKPLV
LFCPPEHYEALVSPILGPLFTYLHMRLSQKWQVINQRSLLCGEDEAADENPESQEMLEEQ
LVRMLTREVMDLITVCCVSKKGADHSSAPPADGDDEEMMATEVTPSAMAELTDLGKCLMK
HEDVCTALLITAFNSLAWKDTLSCQRTTSQLCWPLLKQVLSGTLLADAVTWLFTSVLKGL
QMHGQHDGCMASLVHLAFQIYEALRPRYLEIRAVMEQIPEIQKDSLDQFDCKLLNPSLQK
VADKRRKDQFKRLIAGCIGKPLGEQFRKEVHIKNLPSLFKKTKPMLETEVLDNDGGGLAT
IFEP
|
| External Links |
|---|
| GenBank ID Protein
| 22748937 |
| UniProtKB/Swiss-Prot ID
| Q9HAV4 |
| UniProtKB/Swiss-Prot Entry Name
| XPO5_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_020750.2 |
| GeneCard ID
| XPO5 |
| GenAtlas ID
| XPO5 |
| HGNC ID
| HGNC:17675 |
| References |
|---|
| General References
| Not Available |