| Identification |
|---|
| HMDB Protein ID
| CDBP03830 |
| Secondary Accession Numbers
| Not Available |
| Name
| Exportin-4 |
| Description
| Not Available |
| Synonyms
|
- Exp4
|
| Gene Name
| XPO4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus |
| GO Classification
|
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 13q11 |
| SNPs
| XPO4 |
| Gene Sequence
|
>3456 bp
ATGATGGCGGCGGCGCTGGGGCCCCCAGAAGTGATCGCTCAGCTGGAGAACGCGGCTAAA
GTTCTGATGGCACCACCTTCCATGGTCAATAATGAACAACGCCAGCATGCAGAGCACATA
TTCTTATCATTTAGGAAATCAAAATCACCATTTGCAGTTTGCAAGCATATTTTGGAAACT
AGTAAAGTGGACTATGTCCTCTTTCAAGCTGCCACAGCCATAATGGAAGCAGTTGTCCGA
GAGTGGATTCTCTTGGAAAAAGGTAGCATCGAGTCTCTGCGAACATTCCTTTTAACCTAT
GTCTTACAAAGGCCCAACCTTCAAAAGTATGTTCGGGAACAGATTCTACTAGCAGTAGCA
GTAATTGTAAAAAGAGGATCATTAGATAAATCAATTGACTGCAAAAGCATTTTTCATGAA
GTCAGCCAGTTGATTAGTAGTGGCAATCCCACTGTGCAAACTCTGGCCTGTTCTATTCTG
ACTGCGCTATTGAGTGAATTTTCAAGTTCAAGTAAAACTAGCAACATTGGATTGAGCATG
GAATTCCATGGTAACTGCAAAAGAGTTTTTCAGGAAGAAGACCTTCGTCAGATCTTCATG
TTAACTGTTGAAGTTCTGCAGGAGTTCAGCAGGCGGGAAAACCTCAATGCTCAGATGTCT
TCAGTATTTCAGCGTTACCTTGCACTCGCCAATCAAGTCTTGAGCTGGAACTTTCTTCCT
CCAAATTTGGGCAGACATTATATAGCTATGTTTGAATCCTCGCAAAATGTGCTGTTGAAG
CCAACAGAGTCCTGGCGGGAGACTCTTCTGGACAGCAGAGTTATGGAGCTTTTCTTCACA
GTACATCGAAAAATCAGAGAAGATTCAGATATGGCACAAGATTCTCTGCAGTGCCTTGCC
CAGTTAGCTTCTCTTCATGGACCCATCTTCCCAGATGAAGGATCACAAGTTGATTATCTA
GCACACTTCATTGAGGGATTACTGAATACTATCAATGGAATTGAAATAGAAGATTCTGAA
GCTGTGGGGATCTCCAGCATTATCAGCAACCTGATAACCGTGTTCCCACGAAATGTTTTA
ACTGCCATTCCAAGTGAACTTTTCTCCTCCTTTGTTAACTGCCTCACACACCTCACTTGT
TCTTTTGGGCGAAGTGCTGCATTGGAAGAAGTGCTTGATAAAGATGACATGGTATACATG
GAAGCATATGATAAATTGTTGGAGTCCTGGTTAACTTTGGTTCAAGATGACAAACATTTC
CATAAAGGCTTTTTTACCCAACATGCAGTTCAAGTTTTCAATTCCTATATTCAGTGCCAC
CTAGCTGCTCCAGATGGCACAAGAAATTTGACTGCCAATGGTGTGGCCTCTCGTGAGGAG
GAAGAAATAAGTGAACTTCAAGAGGATGATCGAGACCAGTTTTCTGATCAACTGGCCAGT
GTAGGAATGCTAGGAAGAATTGCTGCAGAACACTGTATACCTCTTCTGACAAGTTTATTA
GAAGAAAGAGTAACAAGACTCCATGGTCAGTTACAACGACATCAGCAACAGTTACTTGCT
TCACCGGGTTCAAGCACTGTTGACAACAAAATGCTTGATGATCTCTATGAAGATATTCAC
TGGCTTATTTTAGTTACAGGCTACCTCTTAGCTGATGATACTCAGGGAGAGACTCCGCTA
ATACCTCCAGAAATAATGGAATATTCCATTAAGCATTCATCTGAAGTTGACATTAATACA
ACACTTCAAATTTTGGGATCTCCAGGAGAAAAGGCTTCTTCCATCCCAGGGTACAACAGA
ACAGATTCTGTGATTAGGCTGTTGTCTGCCATTCTCAGAGTTTCAGAAGTTGAATCTCGA
GCAATAAGAGCAGATCTCACTCATCTACTAAGTCCCCAGATGGGCAAAGATATTGTTTGG
TTTTTAAAACGCTGGGCAAAGACTTATCTCCTGGTGGATGAAAAACTGTATGATCAGATA
AGTCTGCCATTCAGTACAGCGTTCGGAGCAGATACAGAGGGTTCTCAGTGGATAATTGGC
TACCTCTTACAAAAAGTCATCAGTAACCTCTCAGTCTGGAGTAGTGAGCAGGACCTTGCA
AATGACACTGTGCAGCTCCTTGTCACTTTGGTGGAAAGAAGAGAAAGGGCAAACTTAGTA
ATTCAATGTGAGAACTGGTGGAATTTAGCTAAGCAGTTTGCAAGCCGAAGCCCACCTCTT
AATTTCTTGTCAAGTCCTGTGCAGAGGACATTGATGAAGGCTCTAGTCTTAGGAGGTTTT
GCACATATGGACACAGAAACCAAACAGCAGTATTGGACAGAGGTTCTTCAGCCACTTCAG
CAGCGATTCTTAAGAGTGATAAACCAAGAAAACTTCCAGCAGATGTGTCAGCAAGAGGAA
GTCAAGCAGGAAATCACTGCCACACTAGAGGCCCTGTGTGGCATTGCTGAGGCTACCCAG
ATTGACAACGTAGCAATCCTGTTTAATTTTTTAATGGACTTCCTTACCAATTGCATTGGA
TTGATGGAAGTTTACAAGAATACCCCAGAGACTGTCAATCTCATTATAGAAGTTTTTGTT
GAAGTTGCACATAAACAGATATGCTATCTTGGAGAGTCCAAAGCTATGAACTTATATGAA
GCCTGCCTTACTTTGTTGCAAGTGTATTCTAAGAATAATTTAGGGCGGCAAAGAATAGAT
GTTACAGCAGAAGAAGAGCAATACCAAGACCTGCTTCTCATTATGGAACTTCTTACTAAC
CTGCTGTCAAAAGAATTCATAGATTTCAGTGATACAGATGAAGTGTTTAGAGGACATGAG
CCAGGTCAAGCAGCAAACAGATCTGTGTCAGCAGCGGATGTTGTGTTGTATGGAGTAAAC
CTAATTCTGCCCTTGATGTCACAGGATCTCTTGAAGTTTCCAACCCTTTGTAATCAGTAC
TACAAATTAATCACATTTATCTGTGAGATTTTTCCTGAAAAAATACCACAGCTTCCTGAG
GATCTGTTTAAAAGTCTGATGTACTCCCTAGAATTAGGAATGACATCAATGAGTTCGGAG
GTTTGCCAGCTTTGCCTGGAGGCCTTGACACCGTTAGCTGAACAGTGTGCAAAAGCACAA
GAAACAGACTCACCACTTTTTCTAGCAACACGGCACTTTCTTAAGCTGGTTTTTGATATG
CTGGTTTTGCAAAAGCACAACACAGAGATGACCACTGCGGCTGGCGAAGCTTTCTACACG
TTGGTGTGTTTGCACCAGGCTGAATATTCTGAACTGGTCGAAACATTACTATCAAGTCAG
CAAGACCCAGTTATTTACCAGAGATTAGCAGATGCCTTCAACAAGCTCACTGCAAGCAGC
ACTCCTCCTACGCTGGATCGGAAGCAGAAGATGGCCTTCTTAAAGAGTTTAGAAGAATTT
ATGGCAAATGTTGGTGGTCTCCTTTGTGTAAAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 1151 |
| Molecular Weight
| 130138.1 |
| Theoretical pI
| 4.69 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Exportin-4
MMAAALGPPEVIAQLENAAKVLMAPPSMVNNEQRQHAEHIFLSFRKSKSPFAVCKHILET
SKVDYVLFQAATAIMEAVVREWILLEKGSIESLRTFLLTYVLQRPNLQKYVREQILLAVA
VIVKRGSLDKSIDCKSIFHEVSQLISSGNPTVQTLACSILTALLSEFSSSSKTSNIGLSM
EFHGNCKRVFQEEDLRQIFMLTVEVLQEFSRRENLNAQMSSVFQRYLALANQVLSWNFLP
PNLGRHYIAMFESSQNVLLKPTESWRETLLDSRVMELFFTVHRKIREDSDMAQDSLQCLA
QLASLHGPIFPDEGSQVDYLAHFIEGLLNTINGIEIEDSEAVGISSIISNLITVFPRNVL
TAIPSELFSSFVNCLTHLTCSFGRSAALEEVLDKDDMVYMEAYDKLLESWLTLVQDDKHF
HKGFFTQHAVQVFNSYIQCHLAAPDGTRNLTANGVASREEEEISELQEDDRDQFSDQLAS
VGMLGRIAAEHCIPLLTSLLEERVTRLHGQLQRHQQQLLASPGSSTVDNKMLDDLYEDIH
WLILVTGYLLADDTQGETPLIPPEIMEYSIKHSSEVDINTTLQILGSPGEKASSIPGYNR
TDSVIRLLSAILRVSEVESRAIRADLTHLLSPQMGKDIVWFLKRWAKTYLLVDEKLYDQI
SLPFSTAFGADTEGSQWIIGYLLQKVISNLSVWSSEQDLANDTVQLLVTLVERRERANLV
IQCENWWNLAKQFASRSPPLNFLSSPVQRTLMKALVLGGFAHMDTETKQQYWTEVLQPLQ
QRFLRVINQENFQQMCQQEEVKQEITATLEALCGIAEATQIDNVAILFNFLMDFLTNCIG
LMEVYKNTPETVNLIIEVFVEVAHKQICYLGESKAMNLYEACLTLLQVYSKNNLGRQRID
VTAEEEQYQDLLLIMELLTNLLSKEFIDFSDTDEVFRGHEPGQAANRSVSAADVVLYGVN
LILPLMSQDLLKFPTLCNQYYKLITFICEIFPEKIPQLPEDLFKSLMYSLELGMTSMSSE
VCQLCLEALTPLAEQCAKAQETDSPLFLATRHFLKLVFDMLVLQKHNTEMTTAAGEAFYT
LVCLHQAEYSELVETLLSSQQDPVIYQRLADAFNKLTASSTPPTLDRKQKMAFLKSLEEF
MANVGGLLCVK
|
| External Links |
|---|
| GenBank ID Protein
| 148886661 |
| UniProtKB/Swiss-Prot ID
| Q9C0E2 |
| UniProtKB/Swiss-Prot Entry Name
| XPO4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_022459.4 |
| GeneCard ID
| XPO4 |
| GenAtlas ID
| XPO4 |
| HGNC ID
| HGNC:17796 |
| References |
|---|
| General References
| Not Available |