Identification
HMDB Protein ID CDBP03825
Secondary Accession Numbers Not Available
Name 116 kDa U5 small nuclear ribonucleoprotein component
Description Not Available
Synonyms
  1. Elongation factor Tu GTP-binding domain-containing protein 2
  2. SNU114 homolog
  3. U5 snRNP-specific protein, 116 kDa
  4. U5-116 kDa
  5. hSNU114
Gene Name EFTUD2
Protein Type Enzyme
Biological Properties
General Function Involved in GTPase activity
Specific Function Component of the U5 snRNP complex required for pre-mRNA splicing
GO Classification
Function
gtpase activity
nucleoside-triphosphatase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
pyrophosphatase activity
purine nucleotide binding
binding
nucleotide binding
catalytic activity
hydrolase activity
guanyl nucleotide binding
guanyl ribonucleotide binding
gtp binding
Cellular Location
  1. Nucleus
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 17q21.31
SNPs EFTUD2
Gene Sequence
>2919 bp
ATGGATACCGACTTATATGATGAGTTTGGGAATTATATTGGACCAGAGCTTGATTCTGAT
GAAGATGATGATGAATTGGGTAGAGAGACCAAAGATCTTGATGAGATGGATGATGATGAC
GACGACGATGACGTAGGAGATCATGACGATGACCACCCTGGGATGGAGGTGGTGCTGCAT
GAGGACAAGAAGTACTACCCAACAGCCGAGGAGGTGTATGGTCCTGAGGTGGAGACCATA
GTTCAAGAGGAAGACACTCAGCCTCTCACAGAACCCATTATTAAGCCAGTGAAAACCAAG
AAATTCACTCTGATGGAGCAGACATTACCTGTTACGGTGTATGAGATGGATTTCTTGGCG
GATCTGATGGATAACTCAGAGCTCATCAGAAATGTGACCCTTTGTGGACATCTCCACCAT
GGCAAGACATGTTTTGTGGATTGTTTAATTGAACAGACTCACCCGGAAATCAGAAAGCGC
TATGACCAAGATCTGTGCTATACTGACATCCTCTTCACAGAGCAAGAGAGAGGTGTAGGC
ATCAAAAGCACTCCTGTGACAGTGGTCTTGCCAGACACCAAAGGAAAATCTTATCTCTTC
AATATCATGGACACTCCAGGACATGTGAATTTCTCTGATGAGGTCACAGCTGGCTTGCGC
ATCTCAGATGGAGTGGTCCTTTTCATTGATGCTGCTGAGGGGGTGATGCTGAACACAGAG
CGGCTGATCAAGCATGCGGTGCAGGAGAGGCTGGCAGTCACTGTGTGCATCAACAAGATT
GACCGGCTGATCCTGGAGCTGAAGCTGCCTCCAACTGATGCTTATTACAAGCTGCGCCAC
ATTGTGGATGAGGTCAATGGATTAATAAGCATGTATTCCACTGATGAGAACCTGATCCTT
TCCCCACTCCTGGGTAACGTCTGCTTCTCCAGCTCCCAGTACAGCATCTGCTTCACGCTG
GTCTCCTTTGCCAAGATCTATGCCGACACCTTTGGTGACATTAATTACCAAGAATTTGCT
AAAAGACTCTGGGGTGACATCTACTTCAACCCTAAGACGCGAAAGTTCACCAAAAAGGCC
CCAACTAGCAGCTCCCAGAGAAGTTTCGTGGAGTTTATCTTGGAGCCTCTTTATAAGATC
CTCGCCCAGGTTGTAGGTGACGTGGACACCAGCCTCCCACGGACCCTAGACGAGCTTGGC
ATCCACCTGACGAAGGAGGAGCTGAAGCTGAACATCCGCCCCTTGCTCAGGCTGGTCTGC
AAAAAGTTCTTTGGCGAGTTCACAGGCTTTGTGGACATGTGTGTGCAGCATATCCCTTCT
CCAAAGGTGGGCGCCAAGCCCAAGATTGAGCACACCTACACCGGTGGTGTGGACTCCGAC
CTCGGCGAGGCTATGAGTGACTGTGACCCTGATGGCCCCCTGATGTGCCACACTACTAAG
ATGTACAGCACAGATGATGGAGTCCAGTTTCACGCCTTTGGCCGGGTGCTGAGTGGCACC
ATTCATGCTGGGCAGCCTGTGAAGGTACTGGGGGAGAACTACACCCTGGAGGATGAGGAA
GACTCCCAGATATGCACCGTGGGCCGCCTTTGGATCTCTGTGGCCAGGTACCACATCGAG
GTGAACCGTGTTCCTGCTGGCAACTGGGTTCTGATTGAAGGTGTTGATCAACCAATTGTG
AAGACAGCAACCATAACCGAACCCCGAGGCAATGAGGAGGCTCAGATTTTCCGACCCTTG
AAGTTCAATACCACATCTGTTATCAAGATTGCTGTGGAGCCAGTCAACCCCTCAGAGCTG
CCCAAGATGCTTGATGGCCTGCGCAAGGTCAACAAGAGCTATCCATCCCTCACCACCAAG
GTGGAGGAGTCTGGCGAGCATGTGATCCTGGGCACTGGGGAGCTCTACCTGGACTGTGTG
ATGCATGATTTGCGGAAGATGTACTCAGAGATAGACATCAAGGTGGCTGACCCAGTTGTC
ACGTTTTGTGAGACGGTGGTGGAAACATCCTCCCTCAAGTGCTTTGCTGAAACGCCTAAT
AAGAAGAACAAGATCACCATGATTGCTGAGCCTCTTGAGAAGGGCCTGGCAGAGGACATA
GAGAATGAGGTGGTCCAGATTACGTGGAACAGGAAGAAGCTGGGAGAGTTCTTCCAGACC
AAGTACGATTGGGATCTGCTGGCTGCCCGTTCCATCTGGGCTTTTGGCCCTGATGCGACT
GGCCCCAACATTCTGGTGGATGATACTCTGCCCTCTGAGGTGGACAAGGCTCTTCTTGGT
TCAGTGAAGGACAGCATCGTTCAAGGTTTCCAGTGGGGAACCAGGGAGGGCCCCCTCTGT
GATGAATTGATTCGGAATGTCAAGTTTAAGATCCTGGATGCGGTGGTTGCCCAGGAGCCC
CTGCACCGGGGCGGGGGCCAGATCATCCCCACAGCCAGGAGAGTCGTCTACTCTGCCTTC
CTCATGGCTACTCCTCGTCTGATGGAGCCTTACTACTTTGTAGAGGTCCAGGCCCCTGCA
GATTGCGTCTCTGCAGTTTATACCGTCCTGGCCAGGCGCAGGGGGCACGTGACTCAGGAT
GCACCCATCCCAGGCTCCCCTCTGTACACCATCAAAGCTTTTATCCCGGCCATCGACTCT
TTTGGCTTTGAGACTGATCTCCGGACTCACACCCAGGGACAAGCCTTTTCTCTGTCTGTC
TTCCACCACTGGCAGATTGTGCCTGGTGATCCCCTGGACAAGAGCATTGTCATCCGCCCC
TTGGAGCCACAGCCAGCTCCTCACCTGGCCCGGGAATTCATGATCAAAACCCGCCGTAGG
AAGGGCCTCAGTGAAGATGTGAGCATCAGCAAATTCTTCGATGATCCTATGTTGCTGGAA
CTTGCCAAACAGGATGTTGTGCTCAATTACCCCATGTGA
Protein Properties
Number of Residues 972
Molecular Weight 109434.8
Theoretical pI 4.6
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>116 kDa U5 small nuclear ribonucleoprotein component
MDTDLYDEFGNYIGPELDSDEDDDELGRETKDLDEMDDDDDDDDVGDHDDDHPGMEVVLH
EDKKYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTKKFTLMEQTLPVTVYEMDFLA
DLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVG
IKSTPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLNTE
RLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLRHIVDEVNGLISMYSTDENLIL
SPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDIYFNPKTRKFTKKA
PTSSSQRSFVEFILEPLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVC
KKFFGEFTGFVDMCVQHIPSPKVGAKPKIEHTYTGGVDSDLGEAMSDCDPDGPLMCHTTK
MYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHIE
VNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLKFNTTSVIKIAVEPVNPSEL
PKMLDGLRKVNKSYPSLTTKVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVV
TFCETVVETSSLKCFAETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQT
KYDWDLLAARSIWAFGPDATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREGPLC
DELIRNVKFKILDAVVAQEPLHRGGGQIIPTARRVVYSAFLMATPRLMEPYYFVEVQAPA
DCVSAVYTVLARRRGHVTQDAPIPGSPLYTIKAFIPAIDSFGFETDLRTHTQGQAFSLSV
FHHWQIVPGDPLDKSIVIRPLEPQPAPHLAREFMIKTRRRKGLSEDVSISKFFDDPMLLE
LAKQDVVLNYPM
GenBank ID Protein 12803113
UniProtKB/Swiss-Prot ID Q15029
UniProtKB/Swiss-Prot Entry Name U5S1_HUMAN
PDB IDs Not Available
GenBank Gene ID BC002360
GeneCard ID EFTUD2
GenAtlas ID EFTUD2
HGNC ID HGNC:30858
References
General References Not Available