Identification |
HMDB Protein ID
| CDBP03823 |
Secondary Accession Numbers
| Not Available |
Name
| Tubulin polymerization-promoting protein |
Description
| Not Available |
Synonyms
|
- 25 kDa brain-specific protein
- TPPP
- TPPP/p25
- p24
- p25-alpha
|
Gene Name
| TPPP |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in calcium ion binding |
Specific Function
| May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown |
GO Classification
|
Not Available
|
Cellular Location
|
- Nucleus
- Cytoplasm
- Cytoplasm
- cytoskeleton
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:5 |
Locus
| 5p15.3 |
SNPs
| TPPP |
Gene Sequence
|
>660 bp
ATGGCTGACAAGGCCAAGCCTGCCAAAGCTGCCAACAGGACGCCCCCCAAGTCCCCGGGG
GACCCCTCGAAGGACCGGGCAGCCAAGAGGCTGTCGCTGGAATCGGAGGGTGCTGGTGAG
GGGGCAGCCGCATCCCCTGAGCTCAGTGCCCTGGAGGAGGCCTTCCGGCGCTTTGCCGTG
CACGGGGACGCCAGGGCCACCGGGAGGGAGATGCACGGCAAGAACTGGTCGAAGCTGTGC
AAGGACTGCCAGGTGATCGACGGCAGGAACGTGACCGTCACTGACGTGGACATCGTCTTC
AGCAAGATCAAAGGGAAGTCTTGCCGGACCATCACCTTTGAGCAGTTCCAGGAGGCGCTG
GAGGAGCTCGCCAAGAAGCGATTCAAAGACAAGAGCAGCGAGGAGGCCGTTCGCGAGGTG
CACAGGCTCATCGAGGGCAAGGCGCCCATCATCTCAGGGGTGACGAAAGCCATCTCGTCG
CCCACAGTGTCGAGGCTCACGGACACCACCAAGTTCACGGGCTCCCACAAGGAGCGCTTC
GACCCCTCTGGCAAGGGCAAGGGCAAGGCTGGCCGCGTGGATCTGGTGGACGAGTCAGGC
TATGTGTCCGGCTACAAGCACGCAGGCACCTACGACCAGAAGGTGCAAGGGGGCAAGTAG
|
Protein Properties |
Number of Residues
| 219 |
Molecular Weight
| 23693.5 |
Theoretical pI
| 10.12 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Tubulin polymerization-promoting protein
MADKAKPAKAANRTPPKSPGDPSKDRAAKRLSLESEGAGEGAAASPELSALEEAFRRFAV
HGDARATGREMHGKNWSKLCKDCQVIDGRNVTVTDVDIVFSKIKGKSCRTITFEQFQEAL
EELAKKRFKDKSSEEAVREVHRLIEGKAPIISGVTKAISSPTVSRLTDTTKFTGSHKERF
DPSGKGKGKAGRVDLVDESGYVSGYKHAGTYDQKVQGGK
|
External Links |
GenBank ID Protein
| 4062852 |
UniProtKB/Swiss-Prot ID
| O94811 |
UniProtKB/Swiss-Prot Entry Name
| TPPP_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AB017016 |
GeneCard ID
| TPPP |
GenAtlas ID
| TPPP |
HGNC ID
| HGNC:24164 |
References |
General References
| Not Available |