Identification
HMDB Protein ID CDBP03823
Secondary Accession Numbers Not Available
Name Tubulin polymerization-promoting protein
Description Not Available
Synonyms
  1. 25 kDa brain-specific protein
  2. TPPP
  3. TPPP/p25
  4. p24
  5. p25-alpha
Gene Name TPPP
Protein Type Enzyme
Biological Properties
General Function Involved in calcium ion binding
Specific Function May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown
GO Classification Not Available
Cellular Location
  1. Nucleus
  2. Cytoplasm
  3. Cytoplasm
  4. cytoskeleton
Pathways
Gene Properties
Chromosome Location Chromosome:5
Locus 5p15.3
SNPs TPPP
Gene Sequence
>660 bp
ATGGCTGACAAGGCCAAGCCTGCCAAAGCTGCCAACAGGACGCCCCCCAAGTCCCCGGGG
GACCCCTCGAAGGACCGGGCAGCCAAGAGGCTGTCGCTGGAATCGGAGGGTGCTGGTGAG
GGGGCAGCCGCATCCCCTGAGCTCAGTGCCCTGGAGGAGGCCTTCCGGCGCTTTGCCGTG
CACGGGGACGCCAGGGCCACCGGGAGGGAGATGCACGGCAAGAACTGGTCGAAGCTGTGC
AAGGACTGCCAGGTGATCGACGGCAGGAACGTGACCGTCACTGACGTGGACATCGTCTTC
AGCAAGATCAAAGGGAAGTCTTGCCGGACCATCACCTTTGAGCAGTTCCAGGAGGCGCTG
GAGGAGCTCGCCAAGAAGCGATTCAAAGACAAGAGCAGCGAGGAGGCCGTTCGCGAGGTG
CACAGGCTCATCGAGGGCAAGGCGCCCATCATCTCAGGGGTGACGAAAGCCATCTCGTCG
CCCACAGTGTCGAGGCTCACGGACACCACCAAGTTCACGGGCTCCCACAAGGAGCGCTTC
GACCCCTCTGGCAAGGGCAAGGGCAAGGCTGGCCGCGTGGATCTGGTGGACGAGTCAGGC
TATGTGTCCGGCTACAAGCACGCAGGCACCTACGACCAGAAGGTGCAAGGGGGCAAGTAG
Protein Properties
Number of Residues 219
Molecular Weight 23693.5
Theoretical pI 10.12
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Tubulin polymerization-promoting protein
MADKAKPAKAANRTPPKSPGDPSKDRAAKRLSLESEGAGEGAAASPELSALEEAFRRFAV
HGDARATGREMHGKNWSKLCKDCQVIDGRNVTVTDVDIVFSKIKGKSCRTITFEQFQEAL
EELAKKRFKDKSSEEAVREVHRLIEGKAPIISGVTKAISSPTVSRLTDTTKFTGSHKERF
DPSGKGKGKAGRVDLVDESGYVSGYKHAGTYDQKVQGGK
GenBank ID Protein 4062852
UniProtKB/Swiss-Prot ID O94811
UniProtKB/Swiss-Prot Entry Name TPPP_HUMAN
PDB IDs Not Available
GenBank Gene ID AB017016
GeneCard ID TPPP
GenAtlas ID TPPP
HGNC ID HGNC:24164
References
General References Not Available