| Identification |
|---|
| HMDB Protein ID
| CDBP03800 |
| Secondary Accession Numbers
| Not Available |
| Name
| Double-stranded RNA-binding protein Staufen homolog 2 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| STAU2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in double-stranded RNA binding |
| Specific Function
| RNA-binding protein required for the microtubule- dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| double-stranded rna binding |
| binding |
| nucleic acid binding |
| rna binding |
|
| Cellular Location
|
- Nucleus
- Nucleus
- Cytoplasm
- nucleolus
- Endoplasmic reticulum
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:8 |
| Locus
| 8q21.11 |
| SNPs
| STAU2 |
| Gene Sequence
|
>1713 bp
ATGGCAAACCCAAAAGAGAAAACTGCAATGTGTCTGGTAAATGAGTTAGCCCGTTTCAAT
AGAGTCCAACCCCAGTATAAACTTCTGAATGAAAGAGGGCCTGCTCATTCAAAGATGTTC
TCAGTGCAGCTGAGTCTTGGTGAGCAGACATGGGAATCCGAAGGCAGCAGTATAAAGAAG
GCTCAGCAGGCTGTTGCCAATAAAGCTTTGACTGAATCTACGCTTCCCAAACCAGTTCAG
AAGCCACCCAAAAGTAATGTTAACAATAACCCAGGCAGTATAACTCCAACTGTGGAACTG
AATGGGCTTGCTATGAAAAGGGGAGAGCCTGCCATCTACAGGCCATTAGATCCAAAGCCA
TTCCCAAATTATAGAGCTAATTACAACTTTCGGGGCATGTACAATCAGAGGTATCATTGC
CCAGTGCCTAAGATCTTTTATGTTCAGCTCACTGTAGGAAATAATGAATTTTTTGGGGAA
GGAAAGACTCGACAAGCTGCTAGACACAATGCTGCAATGAAAGCCCTCCAAGCACTGCAG
AATGAACCTATTCCAGAAAGATCTCCTCAGAATGGTGAATCAGGAAAGGATATGGATGAT
GACAAAGATGCAAATAAGTCTGAGATCAGCTTAGTGTTTGAAATTGCTCTGAAGCGAAAT
ATGCCTGTCAGTTTTGAGGTTATTAAAGAAAGTGGACCACCACATATGAAAAGCTTTGTT
ACTCGAGTGTCAGTAGGAGAGTTCTCTGCAGAAGGAGAAGGAAATAGCAAAAAACTCTCC
AAGAAGCGCGCTGCGACCACCGTCTTACAGGAGCTTAAAAAACTTCCACCTCTTCCTGTG
GTGGAAAAGCCAAAACTATTTTTTAAAAAACGCCCTAAAACAATAGTAAAGGCCGGACCA
GAATATGGCCAAGGGATGAACCCTATTAGCCGCCTGGCGCAAATTCAACAGGCCAAAAAG
GAAAAGGAGCCGGATTATGTTTTGCTTTCAGAAAGAGGAATGCCTCGACGTCGAGAATTT
GTGATGCAGGTGAAGGTAGGCAATGAAGTTGCTACAGGAACAGGACCTAATAAAAAGATA
GCCAAAAAAAATGCTGCAGAAGCAATGCTGTTACAACTTGGTTATAAAGCATCCACTAAT
CTTCAGGATCAACTTGAGAAGACAGGGGAAAACAAAGGATGGAGTGGTCCAAAGCCTGGG
TTTCCTGAACCAACAAATAATACTCCAAAAGGAATTCTTCATTTGTCTCCTGATGTTTAT
CAAGAGATGGAAGCCAGCCGCCACAAAGTAATCTCTGGCACTACTCTAGGCTATTTGTCA
CCCAAAGATATGAACCAACCTTCAAGCTCTTTCTTCAGTATATCTCCCACATCGAATAGT
TCAGCTACAATTGCCAGGGAACTCCTTATGAATGGAACATCTTCTACAGCTGAAGCCATA
GGTTTAAAAGGAAGTTCTCCTACTCCCCCTTGTTCTCCAGTACAACCTTCAAAACAACTG
GAATATTTAGCAAGGATTCAAGGCTTTCAGGCAGCCTTAAGTGCCTTGAAACAATTTTCT
GAACAAGGACTGGATCCAATCGATGGAGCAATGAATATCGAAAAAGGTTCTCTTGAAAAA
CAAGCCAAGCATCTGAGAGAGAAAGCGGACAATAACCAGGCACCCCCGGGCTCCATCGCT
CAGGACTGCAAGAAATCAAACTCGGCCGTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 570 |
| Molecular Weight
| 62640.1 |
| Theoretical pI
| 10.24 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Double-stranded RNA-binding protein Staufen homolog 2
MANPKEKTAMCLVNELARFNRVQPQYKLLNERGPAHSKMFSVQLSLGEQTWESEGSSIKK
AQQAVANKALTESTLPKPVQKPPKSNVNNNPGSITPTVELNGLAMKRGEPAIYRPLDPKP
FPNYRANYNFRGMYNQRYHCPVPKIFYVQLTVGNNEFFGEGKTRQAARHNAAMKALQALQ
NEPIPERSPQNGESGKDMDDDKDANKSEISLVFEIALKRNMPVSFEVIKESGPPHMKSFV
TRVSVGEFSAEGEGNSKKLSKKRAATTVLQELKKLPPLPVVEKPKLFFKKRPKTIVKAGP
EYGQGMNPISRLAQIQQAKKEKEPDYVLLSERGMPRRREFVMQVKVGNEVATGTGPNKKI
AKKNAAEAMLLQLGYKASTNLQDQLEKTGENKGWSGPKPGFPEPTNNTPKGILHLSPDVY
QEMEASRHKVISGTTLGYLSPKDMNQPSSSFFSISPTSNSSATIARELLMNGTSSTAEAI
GLKGSSPTPPCSPVQPSKQLEYLARIQGFQAALSALKQFSEQGLDPIDGAMNIEKGSLEK
QAKHLREKADNNQAPPGSIAQDCKKSNSAV
|
| External Links |
|---|
| GenBank ID Protein
| 23507039 |
| UniProtKB/Swiss-Prot ID
| Q9NUL3 |
| UniProtKB/Swiss-Prot Entry Name
| STAU2_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF459097 |
| GeneCard ID
| STAU2 |
| GenAtlas ID
| STAU2 |
| HGNC ID
| HGNC:11371 |
| References |
|---|
| General References
| Not Available |