| Identification |
|---|
| HMDB Protein ID
| CDBP03790 |
| Secondary Accession Numbers
| Not Available |
| Name
| SH3 domain-containing guanine exchange factor |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| SGEF |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in Rho guanyl-nucleotide exchange factor activity |
| Specific Function
| Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| enzyme regulator activity |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| small gtpase regulator activity |
| ras guanyl-nucleotide exchange factor activity |
| rho guanyl-nucleotide exchange factor activity |
| Process |
| regulation of ras protein signal transduction |
| regulation of rho protein signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| regulation of cell communication |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
|
| Cellular Location
|
- Cell projection
- ruffle
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| SGEF |
| Gene Sequence
|
>2616 bp
ATGGACGGCGAGAGCGAGGTGGATTTTTCTAGCAACAGCATAACCCCTTTGTGGCGGAGG
CGGTCGATTCCTCAGCCCCACCAGGTTCTGGGCCGGAGCAAGCCGAGGCCCCAGTCCTAC
CAGAGCCCCAACGGGTTACTAATTACGGATTTCCCGGTGGAGGACGGAGGGACGCTCCTC
GCAGCGCAGATTCCCGCCCAGGTGCCCACCGCCTCGGACAGCAGGACGGTACATAGGAGC
CCCCTGCTTCTGGGCGCCCAGCGGAGAGCGGTGGCCAATGGTGGGACGGCATCCCCGGAG
TACAGGGCTGCCTCTCCTCGACTTCGACGGCCCAAGTCACCCAAGCTCCCCAAAGCGGTG
CCTGGCGGCTCCCCGAAATCCCCAGCAAATGGCGCGGTGACCTTGCCTGCGCCGCCGCCG
CCGCCGGTTCTGCGCCCCCCGCGGACTCCTAACGCGCCCGCCCCCTGCACCCCCGAGGAG
GACCTTACTGGGTTGACTGCCAGCCCGGTGCCTTCGCCCACTGCAAATGGCCTTGCCGCT
AATAACGACTCTCCTGGGTCAGGTTCGCAGTCCGGCCGGAAGGCAAAGGACCCCGAACGG
GGGCTCTTTCCTGGGCCCCAGAAAAGTTCTTCGGAACAAAAACTCCCCCTCCAAAGGCTG
CCCTCCCAGGAGAACGAGCTCCTCGAGAATCCTTCCGTGGTTTTGAGTACAAACAGCCCC
GCCGCCCTCAAAGTGGGGAAGCAGCAGATCATTCCGAAGAGTCTGGCCTCGGAAATTAAA
ATAAGTAAATCCAACAATCAAAATGTGGAGCCCCACAAGAGACTCCTCAAGGTGCGCAGC
ATGGTGGAGGGCCTAGGAGGACCCCTGGGTCACGCAGGGGAGGAGAGTGAGGTCGATAAC
GACGTGGATAGCCCAGGGTCTCTGCGGAGAGGCTTGCGGTCCACGTCTTATCGCAGGGCA
GTGGTCAGTGGCTTTGATTTTGACAGTCCTACCAGCTCGAAGAAGAAGAACAGAATGTCC
CAGCCTGTTCTGAAAGTGGTGATGGAAGACAAGGAGAAGTTTTCCAGTCTGGGAAGGATA
AAGAAAAAAATGCTGAAAGGACAAGGAACATTTGATGGGGAAGAAAATGCTGTCCTGTAT
CAAAACTACAAGGAAAAGGCCCTTGACATTGATTCTGATGAAGAGTCAGAGCCCAAAGAA
CAGAAGTCAGATGAAAAAATTGTGATTCACCATAAGCCATTGAGATCCACATGGAGCCAA
CTCTCTGCGGTGAAAAGAAAGGGATTATCTCAGACAGTAAGCCAGGAGGAAAGAAAGAGA
CAAGAGGCTATCTTTGAAGTCATATCCTCTGAACATTCATATTTACTCAGCTTGGAGATC
TTGATACGAATGTTTAAAAATTCTAAAGAACTGAGTGATACAATGACTAAAACCGAGAGG
CACCATCTTTTCTCCAATATTACAGATGTCTGTGAGGCAAGCAAAAAGTTCTTTATAGAG
TTGGAAGCAAGACATCAGAATAATATCTTCATAGATGACATAAGTGACATTGTGGAAAAA
CACACAGCATCCACATTTGACCCATATGTGAAATACTGCACAAATGAAGTCTACCAACAA
CGAACACTACAAAAATTGTTAGCTACCAATCCATCCTTTAAGGAAGTATTGTCAAGGATT
GAGTCCCATGAAGACTGTAGGAACTTACCCATGATCTCTTTTCTCATTCTCCCCATGCAG
AGGGTGACCCGCCTTCCCCTGCTGATGGATACTATCTGTCAAAAAACACCTAAGGACTCT
CCGAAGTATGAAGTCTGCAAAAGAGCCTTGAAGGAAGTTAGCAAGTTGGTTCGACTATGC
AATGAGGGCGCCCGGAAGATGGAAAGGACTGAGATGATGTACACAATTAACTCCCAGCTG
GAATTTAAAATTAAGCCTTTTCCTTTAGTCTCCTCTTCCCGGTGGTTGGTAAAAAGAGGT
GAATTGACAGCCTATGTTGAAGACACTGTGCTTTTCTCAAGAAGGACATCCAAACAGCAA
GTCTACTTCTTTCTCTTTAACGATGTGCTCATTATCACCAAGAAGAAGAGTGAAGAAAGT
TACAACGTCAATGATTATTCCTTAAGAGATCAGCTATTGGTGGAATCTTGTGACAATGAA
GAGCTTAATTCTTCTCCAGGGAAGAACAGCTCCACAATGCTCTATTCAAGACAGAGCTCT
GCCAGTCACCTCTTTACTCTGACAGTCCTTAGTAACCACGCGAATGAGAAAGTGGAGATG
CTACTAGGAGCTGAGACGCAGAGCGAGCGAGCCCGCTGGATAACTGCCCTGGGACACAGC
AGCGGGAAGCCGCCTGCAGACCGAACCTCACTGACCCAGGTGGAAATCGTTAGGTCATTT
ACTGCTAAGCAGCCAGATGAACTCTCCCTGCAGGTGGCTGACGTCGTCCTCATCTATCAA
CGTGTCAGCGATGGCTGGTATGAGGGGGAACGACTACGAGATGGAGAAAGAGGCTGGTTT
CCTATGGAATGTGCCAAGGAGATAACATGTCAAGCTACAATTGATAAGAATGTGGAGAGA
ATGGGACGCTTGCTAGGACTGGAGACCAACGTGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 871 |
| Molecular Weight
| 97358.7 |
| Theoretical pI
| 9.38 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>SH3 domain-containing guanine exchange factor
MDGESEVDFSSNSITPLWRRRSIPQPHQLLGRSKPRPQSYQSPNGLLITDFPVEDGGTLL
AAQIPAQVPTASDSRTVHRSPLLLGAQRRAVANGGTASPEYRAASPRLRRPKSPKLPKAV
PGGSPKSPANGAVTLPAPPPPPVLRPPRTPNAPAPCTPEEDLTGLTASPVPSPTANGLAA
NNDSPGSGSQSGRKAKDPERGLFPGPQKSSSEQKLPLQRLPSQENELLENPSVVLSTNSP
AALKVGKQQIIPKSLASEIKISKSNNQNVEPHKRLLKVRSMVEGLGGPLGHAGEESEVDN
DVDSPGSLRRGLRSTSYRRAVVSGFDFDSPTSSKKKNRMSQPVLKVVMEDKEKFSSLGRI
KKKMLKGQGTFDGEENAVLYQNYKEKALDIDSDEESEPKEQKSDEKIVIHHKPLRSTWSQ
LSAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTER
HHLFSNITDVCEASKKFFIELEARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQ
RTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDS
PKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRG
ELTAYVEDTVLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNE
ELNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVEMLLGAETQSERARWITALGHS
SGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWF
PMECAKEITCQATIDKNVERMGRLLGLETNV
|
| External Links |
|---|
| GenBank ID Protein
| 194473700 |
| UniProtKB/Swiss-Prot ID
| Q96DR7 |
| UniProtKB/Swiss-Prot Entry Name
| SGEF_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_015595.3 |
| GeneCard ID
| SGEF |
| GenAtlas ID
| ARHGEF26 |
| HGNC ID
| HGNC:24490 |
| References |
|---|
| General References
| Not Available |