| Identification |
|---|
| HMDB Protein ID
| CDBP03788 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sterol regulatory element-binding protein cleavage-activating protein |
| Description
| Not Available |
| Synonyms
|
- SCAP
- SREBP cleavage-activating protein
|
| Gene Name
| SCAP |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in unfolded protein binding |
| Specific Function
| Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
|
| Cellular Location
|
- Golgi apparatus membrane
- Cytoplasmic vesicle
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
- Multi-pass membrane protein
- Multi- pass membrane protein
- COPII- coated vesicle membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3p21.31 |
| SNPs
| SCAP |
| Gene Sequence
|
>3840 bp
ATGACCCTGACTGAAAGGCTGCGTGAGAAGATATCTCGGGCCTTCTACAACCATGGGCTC
CTCTGTGCATCCTATCCCATCCCCATCATCCTCTTCACAGGGTTCTGCATCTTAGCCTGC
TGCTACCCACTGCTGAAACTCCCCTTGCCAGGAACAGGACCTGTGGAATTCACCACCCCT
GTGAAGGATTACTCGCCCCCACCTGTGGACTCTGACCGCAAACAAGGAGAGCCTACTGAG
CAGCCTGAGTGGTATGTGGGTGCCCCGGTGGCTTATGTCCAGCAGATATTTGTGAAGTCC
TCAGTGTTTCCCTGGCACAAGAACCTCCTGGCAGTAGATGTATTTCGTTCACCTTTGTCC
CGGGCATTCCAACTGGTGGAGGAGATCCGGAACCACGTGCTGAGAGACAGCTCTGGGATC
AGGAGCTTGGAGGAGTTGTGTCTGCAAGTGACCGACCTGCTGCCAGGCCTTAGGAAGCTC
AGGAACCTACTCCCTGAGCATGGATGCCTGCTGCTGTCCCCTGGGAACTTCTGGCAGAAT
GACTGGGAACGCTTCCATGCTGATCCTGACATCATTGGGACCATCCACCAGCACGAGCCT
AAAACCCTGCAGACTTCAGCCACACTCAAAGACTTGTTATTTGGTGTTCCTGGGAAGTAC
AGCGGGGTGAGCCTCTACACCAGGAAGAGGATGGTCTCCTACACCATCACCCTGGTCTTC
CAGCACTACCATGCCAAGTTCCTGGGCAGCCTGCGTGCCCGCCTGATGCTTCTGCACCCC
AGCCCCAACTGCAGCCTTCGGGCGGAGAGCCTGGTCCACGTGCACTTCAAGGAGGAGATT
GGTGTCGCTGAGCTCATCCCCCTTGTGACCACCTACATCATCTTGTTTGCCTACATCTAC
TTCTCCACGCGGAAGATCGACATGGTCAAGTCCAAGTGGGGGCTGGCCCTGGCTGCCGTG
GTCACAGTGCTCAGCTCGCTGCTCATGTCTGTGGGACTCTGCACACTCTTCGGCCTGACG
CCCACCCTCAATGGCGGCGAGATTTTCCCCTACCTTGTGGTGGTTATTGGGTTAGAGAAT
GTGTTGGTGCTCACCAAGTCTGTGGTCTCAACCCCGGTAGACCTGGAGGTGAAGCTGCGG
ATCGCCCAAGGCCTAAGCAGCGAGAGCTGGTCCATCATGAAGAACATGGCCACGGAGCTG
GGCATCATCCTCATCGGCTACTTCACCCTAGTGCCCGCCATCCAGGAGTTCTGTCTCTTT
GCTGTCGTGGGGCTGGTGTCTGACTTCTTCCTTCAGATGCTGTTTTTCACCACTGTCCTG
TCCATTGACATTCGCCGGATGGAGCTAGCAGACCTGAACAAGCGACTGCCCCCTGAGGCC
TGCCTGCCCTCAGCCAAGCCAGTGGGACAGCCAACGCGCTACGAGCGGCAGCTGGCTGTG
AGGCCGTCCACACCCCACACCATCACGTTGCAGCCGTCTTCCTTCCGAAACCTGCGGCTC
CCCAAGAGGCTGCGTGTTGTCTACTTCCTGGCCCGCACCCGCCTGGCACAGCGCCTCATC
ATGGCTGGCACCGTTGTCTGGATTGGCATCCTGGTATACACAGACCCAGCAGGGCTGCGC
AACTACCTCGCTGCCCAGGTGACGGAACAGAGCCCATTGGGTGAGGGAGCCCTGGCTCCC
ATGCCCGTGCCTAGTGGCATGCTGCCCCCCAGCCACCCGGACCCTGCCTTCTCCATCTTC
CCACCTGATGCCCCTAAGCTACCTGAGAACCAGACGTCGCCAGGCGAGTCACCTGAGCGT
GGAGGTCCAGCAGAGGTTGTCCATGACAGCCCAGTCCCAGAGGTAACCTGGGGGCCTGAG
GATGAGGAACTTTGGAGGAAATTGTCCTTCCGCCACTGGCCGACGCTCTTCAGCTATTAC
AACATCACACTGGCCAAGAGGTACATCAGCCTGCTGCCCGTCATCCCAGTCACGCTCCGC
CTGAACCCGAGGGAGGCTCTGGAGGGCCGGCACCCTCAGGACGGCCGCAGTGCCTGGCCC
CCACCGGGGCCCATACCTGCTGGGCACTGGGAAGCAGGACCCAAGGGCCCAGGTGGGGTG
CAGGCCCATGGAGACGTCACGCTGTACAAGGTGGCGGCGCTGGGCCTGGCCACCGGCATC
GTCTTGGTGCTGCTGCTGCTCTGCCTCTACCGCGTGCTATGCCCGCGCAACTACGGGCAG
CTGGGTGGTGGGCCCGGGCGGCGGAGGCGCGGGGAGCTGCCCTGCGACGACTACGGCTAT
GCGCCACCCGAGACGGAGATCGTGCCGCTTGTGCTGCGCGGCCACCTCATGGACATCGAG
TGCCTGGCCAGCGACGGCATGCTGCTGGTGAGCTGCTGCCTGGCAGGCCACGTCTGCGTG
TGGGACGCGCAGACCGGGGATTGCCTAACGCGCATTCCGCGCCCAGGCAGGCAGCGCCGG
GACAGTGGCGTGGGCAGCGGGCTTGAGGCTCAGGAGAGCTGGGAACGACTTTCAGATGGT
GGGAAGGCTGGTCCAGAGGAGCCTGGGGACAGCCCTCCCCTGAGACACCGCCCCCGGGGC
CCTCCGCCGCCTTCCCTCTTCGGGGACCAGCCTGACCTCACCTGCTTAATTGACACCAAC
TTTTCAGCGCAGCCTCGGTCCTCACAGCCCACTCAGCCCGAGCCCCGGCACCGGGCGGTC
TGTGGCCGCTCTCGGGACTCCCCAGGCTATGACTTCAGCTGCCTGGTGCAGCGGGTGTAC
CAGGAGGAGGGGCTGGCGGCCGTCTGCACACCAGCCCTGCGCCCACCCTCGCCTGGGCCG
GTGCTGTCCCAGGCCCCTGAGGACGAGGGTGGCTCCCCCGAGAAAGGCTCCCCTTCCCTC
GCCTGGGCCCCCAGTGCCGAGGGTTCCATCTGGAGCTTGGAGCTGCAGGGCAACCTCATC
GTGGTGGGGCGGAGCAGCGGCCGGCTGGAGGTGTGGGACGCCATTGAAGGGGTGCTGTGC
TGCAGCAGCGAGGAGGTCTCCTCAGGCATTACCGCTCTGGTGTTCTTGGACAAAAGGATT
GTGGCTGCACGGCTCAACGGTTCCCTTGATTTCTTCTCCTTGGAGACCCACACTGCCCTC
AGCCCCCTGCAGTTTAGAGGGACCCCAGGGCGGGGCAGTTCCCCTGCCTCTCCAGTGTAC
AGCAGCAGCGACACAGTGGCCTGTCACCTGACCCACACAGTGCCCTGTGCACACCAAAAA
CCCATCACAGCCCTGAAAGCCGCTGCTGGGCGCTTGGTGACTGGGAGCCAAGACCACACA
CTGAGAGTGTTCCGTCTGGAGGACTCGTGCTGCCTCTTCACCCTTCAGGGCCACTCAGGG
GCCATCACGACCGTGTACATTGACCAGACCATGGTGCTGGCCAGTGGAGGACAAGATGGG
GCCATCTGCCTGTGGGATGTACTGACTGGCAGCCGGGTCAGCCATGTGTTTGCTCACCGT
GGGGATGTCACCTCCCTTACCTGTACCACCTCCTGTGTCATCAGCAGTGGCCTGGATGAC
CTCATCAGCATCTGGGACCGCAGCACAGGCATCAAGTTCTACTCCATTCAGCAGGACCTG
GGCTGTGGTGCAAGCTTGGGTGTCATCTCAGACAACCTGCTGGTGACTGGCGGCCAGGGC
TGTGTCTCCTTTTGGGACCTAAACTACGGGGACCTGTTACAGACAGTCTACCTGGGGAAG
AACAGTGAGGCCCAGCCTGCCCGCCAGATCCTGGTGCTGGACAACGCTGCCATTGTCTGC
AACTTTGGCAGTGAGCTCAGCCTGGTGTATGTGCCCTCTGTGCTGGAGAAGCTGGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1279 |
| Molecular Weight
| 139727.6 |
| Theoretical pI
| 6.85 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["19-39", "280-300", "313-333", "345-365", "402-422", "424-444", "519-539", "710-730"]
|
| Protein Sequence
|
>Sterol regulatory element-binding protein cleavage-activating protein
MTLTERLREKISRAFYNHGLLCASYPIPIILFTGFCILACCYPLLKLPLPGTGPVEFTTP
VKDYSPPPVDSDRKQGEPTEQPEWYVGAPVAYVQQIFVKSSVFPWHKNLLAVDVFRSPLS
RAFQLVEEIRNHVLRDSSGIRSLEELCLQVTDLLPGLRKLRNLLPEHGCLLLSPGNFWQN
DWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRMVSYTITLVF
QHYHAKFLGSLRARLMLLHPSPNCSLRAESLVHVHFKEEIGVAELIPLVTTYIILFAYIY
FSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLEN
VLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLF
AVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACLPSAKPVGQPTRYERQLAV
RPSTPHTITLQPSSFRNLRLPKRLRVVYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLR
NYLAAQVTEQSPLGEGALAPMPVPSGMLPPSHPDPAFSIFPPDAPKLPENQTSPGESPER
GGPAEVVHDSPVPEVTWGPEDEELWRKLSFRHWPTLFSYYNITLAKRYISLLPVIPVTLR
LNPREALEGRHPQDGRSAWPPPGPIPAGHWEAGPKGPGGVQAHGDVTLYKVAALGLATGI
VLVLLLLCLYRVLCPRNYGQLGGGPGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIE
CLASDGMLLVSCCLAGHVCVWDAQTGDCLTRIPRPGRQRRDSGVGSGLEAQESWERLSDG
GKAGPEEPGDSPPLRHRPRGPPPPSLFGDQPDLTCLIDTNFSAQPRSSQPTQPEPRHRAV
CGRSRDSPGYDFSCLVQRVYQEEGLAAVCTPALRPPSPGPVLSQAPEDEGGSPEKGSPSL
AWAPSAEGSIWSLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRI
VAARLNGSLDFFSLETHTALSPLQFRGTPGRGSSPASPVYSSSDTVACHLTHTVPCAHQK
PITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDG
AICLWDVLTGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFYSIQQDL
GCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVC
NFGSELSLVYVPSVLEKLD
|
| External Links |
|---|
| GenBank ID Protein
| 66932902 |
| UniProtKB/Swiss-Prot ID
| Q12770 |
| UniProtKB/Swiss-Prot Entry Name
| SCAP_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_012235.2 |
| GeneCard ID
| SCAP |
| GenAtlas ID
| SCAP |
| HGNC ID
| HGNC:30634 |
| References |
|---|
| General References
| Not Available |