| Identification |
|---|
| HMDB Protein ID
| CDBP03786 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ribosome maturation protein SBDS |
| Description
| Not Available |
| Synonyms
|
- Shwachman-Bodian-Diamond syndrome protein
|
| Gene Name
| SBDS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ribosome biogenesis |
| Specific Function
| May be involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. May trigger the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:7 |
| Locus
| 7q11.21 |
| SNPs
| SBDS |
| Gene Sequence
|
>753 bp
ATGTCGATCTTCACCCCCACCAACCAGATCCGCCTAACCAATGTGGCCGTGGTACGGATG
AAGCGTGCCGGGAAGCGCTTCGAAATCGCCTGCTACAAAAACAAGGTCGTCGGCTGGCGG
AGGGCGTGGGAAAAAGACCTCGATGAAGTTCTGCAGACCCACTCAGTGTTTGTAAATGTT
TCTAAAGGTCAGGTTGCCAAAAAGGAAGATCTCATCAGTGCGTTTGGAACAGATGACCAA
ACTGAAATCTGTAAGCAGATTTTGGCTAAAGGAGAAGTTCAAGTTTCAGATAAAGAAAGA
CACACACAACTGGGGCAGATGTTTAGGGACATTGCAACTTTTGTGGCAGACAAATGTGTG
AATCCTGAAACAAAGGGACCATACACCGTGATCCTTATTGAGAGAGCCATGAAGGACATC
CACTATTTGGTGAAACCAAACAAGAGTACAAAACAGCAGGCTTTGGAAGTGATAAAGCAG
TTAAAAGAGAAAATGAAGATAGAACGTGCTCACATGAGGCTTCGGTTCATCCTTCCAGTC
AATGAAGGCAAGAAGCTGAAAGAAAAGCTCAAGCCACTGATCAAGGTCATAGAAAGTGAA
GATTATGGCCAACAGTTAGAAATCGTATGTCTGATTGACCCGGGCTGCTTCCGAGAAATT
GATGAGCTAATAAAAAAGGAAACTAAAGGCAAAGGTTCTTTGGAAGTACTCAATCTGAAA
GATGTAGAAGAAGGAGATGAGAAATTTGAATGA
|
| Protein Properties |
|---|
| Number of Residues
| 250 |
| Molecular Weight
| 28763.3 |
| Theoretical pI
| 9.15 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ribosome maturation protein SBDS
MSIFTPTNQIRLTNVAVVRMKRAGKRFEIACYKNKVVGWRSGVEKDLDEVLQTHSVFVNV
SKGQVAKKEDLISAFGTDDQTEICKQILTKGEVQVSDKERHTQLEQMFRDIATIVADKCV
NPETKRPYTVILIERAMKDIHYSVKTNKSTKQQALEVIKQLKEKMKIERAHMRLRFILPV
NEGKKLKEKLKPLIKVIESEDYGQQLEIVCLIDPGCFREIDELIKKETKGKGSLEVLNLK
DVEEGDEKFE
|
| External Links |
|---|
| GenBank ID Protein
| 4929663 |
| UniProtKB/Swiss-Prot ID
| Q9Y3A5 |
| UniProtKB/Swiss-Prot Entry Name
| SBDS_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF151855 |
| GeneCard ID
| SBDS |
| GenAtlas ID
| SBDS |
| HGNC ID
| HGNC:19440 |
| References |
|---|
| General References
| Not Available |