| Identification |
|---|
| HMDB Protein ID
| CDBP03769 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ras and Rab interactor 2 |
| Description
| Not Available |
| Synonyms
|
- Ras association domain family 4
- Ras inhibitor JC265
- Ras interaction/interference protein 2
|
| Gene Name
| RIN2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in signal transduction |
| Specific Function
| Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP |
| GO Classification
|
| Function |
| binding |
| protein binding |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
|
| Cellular Location
|
- Cytoplasm (Probable)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 20p11.22 |
| SNPs
| RIN2 |
| Gene Sequence
|
>2688 bp
ATGACAGCTTGGACCATGGGCGCCCGCGGTCTGGACAAGCGAGGAAGTTTCTTTAAGCTC
ATTGACACAATTGCCTCGGAGATCGGAGAACTGAAACAGGAGATGGTGCGGACAGATGTC
AACCTGGAAAATGGCCTGGAACCCGCTGAAACCCACAGCATGGTAAGACACAAGGATGGT
GGCTATTCCGAGGAAGAGGACGTGAAGACCTGTGCCCGGGACTCAGGCTATGACAGCCTC
TCCAACAGGCTCAGCATCTTGGACCGGCTCCTCCACACCCACCCCATATGGCTGCAGCTG
AGTCTGAGTGAGGAGGAGGCAGCAGAGGTCCTGCAGGCCCAGCCTCCGGGGATCTTCCTG
GTTCATAAATCTACCAAGATGCAGAAGAAAGTCCTCTCCCTCCGCCTGCCCTGTGAATTT
GGGGCCCCACTCAAGGAATTTGCCATAAAGGAAAGCACATACACCTTTTCCCTGGAAGGA
TCCGGAATCAGTTTCGCAGATTTATTCCGGCTCATTGCTTTCTACTGCATCAGCAGGGAT
GTTCTACCATTTACCTTGAAGTTGCCTTATGCCATTTCAACAGCCAAGTCGGAGGCTCAG
CTTGAAGAACTGGCCCAGATGGGACTAAATTTCTGGAGCTCCCCAGCTGACAGCAAACCC
CCGAACCTTCCACCTCCCCATAGGCCTCTTTCCTCCGACGGTGTCTGTCCTGCCTCCCTG
CGTCAGCTCTGCCTTATAAATGGAGTGCATTCTATCAAAACCAGGACGCCTTCAGAGCTG
GAGTGCAGCCAGACCAACGGGGCTCTGTGCTTTATTAATCCCCTTTTCTTGAAAGTGCAC
AGCCAGGACCTCAGTGGAGGCCTGAAACGGCCGAGCACAAGGACTCCCAACGCGAATGGC
ACGGAGCGGACTCGGTCCCCCCCACCCAGGCCCCCGCCACCCGCTATTAATAGTCTCCAC
ACAAGCCCTCGGCTGGCCAGGACTGAAACCCAGACGAGCATGCCAGAAACAGTCAACCAT
AACAAACATGGGAACGTAGCTCTGCCTGGAACGAAACCAACTCCCATCCCTCCACCCCGG
CTGAAGAAGCAGGCTTCTTTTCTGGAAGCAGAGGGCGGTGCAAAGACCTTGAGCGGCGGC
CGGCCGGGCGCAGGCCCGGAGCTGGAGCTGGGCACAGCTGGCAGCCCAGGTGGGGCCCCG
CCTGAGGCCGCCCCGGGGGATTGCACAAGGGCCCCGCCGCCCAGCTCTGAATCACGGCCC
CCGTGCCATGGAGGCCGGCAGCGGCTGAGCGACATGAGCATTTCTACTTCCTCCTCCGAC
TCGCTGGAGTTCGACCGGAGCATGCCTCTGTTTGGCTACGAGGCGGACACCAACAGCAGC
CTGGAGGACTACGAGGGGGAAAGTGACCAAGAGACCATGGCGCCCCCCATCAAGTCCAAA
AAGAAAAGGAGCAGCTCCTTCGTGCTGCCCAAGCTCGTCAAGTCCCAGCTGCAGAAGGTG
AGCGGGGTGTTCAGCTCCTTCATGACCCCGGAGAAGCGGATGGTCCGCAGGATCGCCGAG
CTTTCCCGGGACAAATGCACCTACTTCGGGTGCTTAGTGCAGGACTACGTGAGCTTCCTG
CAGGAGAACAAGGAGTGCCACGTGTCCAGCACCGACATGCTGCAGACCATCCGGCAGTTC
ATGACCCAGGTCAAGAACTATTTGTCTCAGAGCTCGGAGCTGGACCCCCCCATCGAGTCG
CTGATCCCTGAAGACCAAATAGATGTGGTGCTGGAAAAAGCCATGCACAAGTGCATCTTG
AAGCCCCTCAAGGGGCACGTGGAGGCCATGCTGAAGGACTTTCACATGGCCGATGGCTCA
TGGAAGCAACTCAAGGAGAACCTGCAGCTTGTGCGGCAGAGGAATCCGCAGGAGCTGGGG
GTCTTCGCCCCGACCCCTGATTTTGTGGATGTGGAGAAAATCAAAGTCAAGTTCATGACC
ATGCAGAAGATGTATTCGCCGGAAAAGAAGGTCATGCTGCTGCTGCGGGTCTGCAAGCTC
ATTTACACGGTCATGGAGAACAACTCAGGGAGGATGTATGGCGCTGATGACTTCTTGCCA
GTCCTGACCTATGTCATAGCCCAGTGTGACATGCTTGAATTGGACACTGAAATCGAGTAC
ATGATGGAGCTCCTAGACCCATCGCTGTTACATGGAGAAGGAGGCTATTACTTGACAAGC
GCATATGGAGCACTTTCTCTGATAAAGAATTTCCAAGAAGAACAAGCAGCGCGACTGCTC
AGCTCAGAAACCAGAGACACCCTGAGGCAGTGGCACAAACGGAGAACCACCAACCGGACC
ATCCCCTCTGTGGACGACTTCCAGAATTACCTCCGAGTTGCATTTCAGGAGGTCAACAGT
GGTTGCACAGGAAAGACCCTCCTTGTGAGACCTTACATCACCACTGAGGATGTGTGTCAG
ATCTGCGCTGAGAAGTTCAAGGTGGGGGACCCTGAGGAGTACAGCCTCTTTCTCTTCGTT
GACGAGACATGGCAGCAGCTGGCAGAGGACACTTACCCTCAAAAAATCAAGGCGGAGCTG
CACAGCCGACCACAGCCCCACATCTTCCACTTTGTCTACAAACGCATCAAGAACGATCCT
TATGGCATCATTTTCCAGAACGGGGAAGAAGACCTCACCACCTCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 895 |
| Molecular Weight
| 100162.3 |
| Theoretical pI
| 6.55 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ras and Rab interactor 2
MTAWTMGARGLDKRGSFFKLIDTIASEIGELKQEMVRTDVNLENGLEPAETHSMVRHKDG
GYSEEEDVKTCARDSGYDSLSNRLSILDRLLHTHPIWLQLSLSEEEAAEVLQAQPPGIFL
VHKSTKMQKKVLSLRLPCEFGAPLKEFAIKESTYTFSLEGSGISFADLFRLIAFYCISRD
VLPFTLKLPYAISTAKSEAQLEELAQMGLNFWSSPADSKPPNLPPPHRPLSSDGVCPASL
RQLCLINGVHSIKTRTPSELECSQTNGALCFINPLFLKVHSQDLSGGLKRPSTRTPNANG
TERTRSPPPRPPPPAINSLHTSPRLARTETQTSMPETVNHNKHGNVALPGTKPTPIPPPR
LKKQASFLEAEGGAKTLSGGRPGAGPELELGTAGSPGGAPPEAAPGDCTRAPPPSSESRP
PCHGGRQRLSDMSISTSSSDSLEFDRSMPLFGYEADTNSSLEDYEGESDQETMAPPIKSK
KKRSSSFVLPKLVKSQLQKVSGVFSSFMTPEKRMVRRIAELSRDKCTYFGCLVQDYVSFL
QENKECHVSSTDMLQTIRQFMTQVKNYLSQSSELDPPIESLIPEDQIDVVLEKAMHKCIL
KPLKGHVEAMLKDFHMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMT
MQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEY
MMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSETRDTLRQWHKRRTTNRT
IPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFV
DETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS
|
| External Links |
|---|
| GenBank ID Protein
| 18413654 |
| UniProtKB/Swiss-Prot ID
| Q8WYP3 |
| UniProtKB/Swiss-Prot Entry Name
| RIN2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB060339 |
| GeneCard ID
| RIN2 |
| GenAtlas ID
| RIN2 |
| HGNC ID
| HGNC:18750 |
| References |
|---|
| General References
| Not Available |