| Identification |
|---|
| HMDB Protein ID
| CDBP03768 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ras and Rab interactor 1 |
| Description
| Not Available |
| Synonyms
|
- Ras inhibitor JC99
- Ras interaction/interference protein 1
|
| Gene Name
| RIN1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in signal transduction |
| Specific Function
| Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis |
| GO Classification
|
| Function |
| binding |
| protein binding |
| Process |
| signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
|
| Cellular Location
|
- Cytoplasm
- Cytoplasm
- Membrane
- cytoskeleton
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11q13.2 |
| SNPs
| RIN1 |
| Gene Sequence
|
>2352 bp
ATGGAAAGCCCTGGAGAGTCAGGCGCGGGCTCTCCTGGAGCCCCCAGCCCGTCCAGCTTC
ACTACTGGGCACCTGGCGAGAGAAAAGCCAGCCCAGGACCCACTGTATGACGTGCCCAAT
GCCAGCGGCGGGCAGGCAGGCGGGCCGCAGCGGCCGGGGCGCGTTGTGAGCCTGCGGGAG
CGCCTGCTGCTCACCCGGCCCGTGTGGCTGCAGCTGCAAGCCAACGCAGCGGCCGCACTG
CACATGCTGAGGACCGAGCCCCCGGGGACGTTCCTCGTGCGGAAATCTAACACCCGCCAG
TGCCAGGCCCTGTGCATGCGGTTGCCTGAAGCCAGTGGCCCCTCCTTCGTCTCCAGCCAC
TACATCCTGGAGAGCCCTGGCGGCGTCTCCTTGGAGGGCTCGGAGCTCATGTTCCCAGAC
CTAGTCCAGCTCATCTGTGCCTACTGCCACACCCGGGACATCCTTCTCCTCCCGCTGCAG
CTCCCCAGAGCCATCCACCACGCAGCCACTCACAAAGAGCTGGAGGCCATCTCCCATCTG
GGCATTGAGTTCTGGAGCTCCTCCCTCAACATCAAGGCTCAGCGGGGCCCGGCTGGAGGC
CCAGTGTTGCCCCAGCTGAAGGCCCGGTCCCCTCAAGAGCTGGACCAGGGCACCGGAGCC
GCCTTGTGCTTCTTCAACCCCCTGTTCCCGGGGGACCTAGGGCCCACCAAGCGGGAGAAA
TTCAAGAGAAGCTTCAAAGTGCGCGTGTCCACAGAGACCTCCAGCCCCCTGTCTCCACCT
GCCGTGCCACCTCCCCCCGTCCCCGTGCTGCCAGGGGCAGTCCCCAGCCAGACAGAGCGG
CTGCCCCCTTGCCAGCTGCTACGGAGGGAGAGCTCAGTGGGGTACCGCGTGCCAGCAGGC
AGTGGCCCTAGCCTTCCGCCTATGCCCTCCCTCCAAGAGGTGGACTGCGGCTCCCCCAGC
AGCTCCGAGGAGGAGGGGGTGCCAGGGTCCCGGGGGAGCCCAGCGACCTCACCCCACCTG
GGCCGCCGACGACCTCTGCTTCGGTCCATGAGCGCCGCCTTCTGCTCCCTACTGGCACCG
GAGCGGCAGGTGGGCCGGGCTGCGGCAGCACTGATGCAGGACCGACACACAGCCGCGGGC
CAGCTGGTGCAGGACCTACTGACCCAGGTGCGGGCTGGGCCCGAGCCCCAGGAGCTGCAG
GGCATCCGTCAGGCGCTGAGCCGGGCCCGGGCCATGCTGAGTGCGGAGCTGGGCCCTGAG
AAGCTGCTGTCGCCTAAGAGGCTGGAACATGTCCTGGAGAAGTCATTGCATTGCTCTGTG
CTCAAGCCTCTCCGGCCCATCCTGGCAGCCCGCCTGCGGCGCCGGCTTGCCGCAGACGGC
TCCCTGGGCCGCCTAGCTGAGGGCCTCCGCCTGGCCCGGGCCCAGGGCCCCGGAGCCTTC
GGGTCCCACCTGAGCCTGCCCTCCCCAGTAGAGTTGGAGCAAGTGCGCCAGAAGCTGCTG
CAGCTGCTCCGCACCTACTCACCCAGCGCCCAGGTCAAGCGGCTCCTGCAGGCCTGCAAG
CTGCTCTACATGGCCCTGAGGACCCAGGAAGGGGAGGGCGCGGGTGCCGACGAGTTCCTG
CCTCTGCTGAGCCTCGTCTTGGCCCACTGTGACCTTCCTGAGCTGCTGCTGGAGGCCGAG
TACATGTCGGAGCTGCTGGAGCCCAGCCTGCTTACTGGAGAGGGTGGCTACTACCTGACC
AGCCTCTCTGCCAGCCTGGCCCTGCTGAGTGGCCTGGGTCAGGCCCACACCCTCCCACTG
AGCCCCGTGCAGGAGCTACGGCGCTCCCTCAGCCTCTGGGAGCAGCGCCGCCTGCCTGCC
ACCCACTGCTTCCAGCACCTCCTCCGAGTAGCCTATCAGGATCCCAGCAGTGGCTGCACC
TCCAAGACCCTGGCCGTGCCCCCAGAGGCCTCGATTGCCACCCTGAACCAGCTCTGTGCC
ACCAAGTTCCGAGTGACCCAGCCCAACACTTTTGGCCTCTTCCTGTACAAGGAGCAGGGC
TACCACCGCCTGCCCCCTGGGGCCCTGGCCCACAGGCTGCCCACCACTGGCTACCTCGTC
TACCGCCGGGCAGAGTGGCCTGAGACCCAGGGGGCTGTGACAGAGGAGGAGGGCAGTGGG
CAGTCAGAGGCAAGAAGCAGAGGGGAGGAGCAAGGGTGCCAGGGAGATGGGGATGCTGGG
GTCAAAGCCAGCCCCAGGGACATTCGGGAACAGTCTGAGACAACTGCTGAAGGGGGCCAG
GGTCAAGCCCAGGAAGGCCCTGCTCAGCCAGGGGAACCAGAGGCAGAGGGAAGCCGGGCA
GCAGAGGAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 783 |
| Molecular Weight
| 84098.0 |
| Theoretical pI
| 8.08 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ras and Rab interactor 1
MESPGESGAGSPGAPSPSSFTTGHLAREKPAQDPLYDVPNASGGQAGGPQRPGRVVSLRE
RLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSH
YILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHL
GIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREK
FKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAG
SGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAP
ERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPE
KLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRLARAQGPGAF
GSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFL
PLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPL
SPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCA
TKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSG
QSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRA
AEE
|
| External Links |
|---|
| GenBank ID Protein
| 15680148 |
| UniProtKB/Swiss-Prot ID
| Q13671 |
| UniProtKB/Swiss-Prot Entry Name
| RIN1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC014417 |
| GeneCard ID
| RIN1 |
| GenAtlas ID
| RIN1 |
| HGNC ID
| HGNC:18749 |
| References |
|---|
| General References
| Not Available |