Cannabis Compound Database: Showing Protein GTP-binding protein Rheb (CDBP03759)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP03759

Secondary Accession Numbers

Not Available

Name

GTP-binding protein Rheb

Description

Not Available

Synonyms

Ras homolog enriched in brain

Gene Name

RHEB

Protein Type

Enzyme

Biological Properties

General Function

Involved in GTP binding

Specific Function

Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity

GO Classification

Component
membrane
cell part
intracellular
Function
nucleotide binding
catalytic activity
hydrolase activity
guanyl nucleotide binding
guanyl ribonucleotide binding
gtp binding
gtpase activity
nucleoside-triphosphatase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
pyrophosphatase activity
purine nucleotide binding
binding
Process
small gtpase mediated signal transduction
biological regulation
regulation of biological process
regulation of cellular process
signal transduction
intracellular signal transduction

Cellular Location

Cell membrane
Lipid-anchor
Cytoplasmic side (Potential)

Pathways

Name	SMPDB/Pathwhiz	KEGG
Leucine Stimulation on Insulin Signaling		Not Available

Gene Properties

Chromosome Location

Chromosome:7

Locus

7q36

SNPs

RHEB

Gene Sequence

>555 bp
ATGCCGCAGTCCAAGTCCCGGAAGATCGCGATCCTGGGCTACCGGTCTGTGGGGAAATCC
TCATTGACGATTCAATTTGTTGAAGGCCAATTTGTGGACTCCTACGATCCAACCATAGAA
AACACTTTTACAAAGTTGATCACAGTAAATGGACAAGAATATCATCTTCAACTTGTAGAC
ACAGCCGGGCAAGATGAATATTCTATCTTTCCTCAGACATACTCCATAGATATTAATGGC
TATATTCTTGTGTATTCTGTTACATCAATCAAAAGTTTTGAAGTGATTAAAGTTATCCAT
GGCAAATTGTTGGATATGGTGGGGAAAGTACAAATACCTATTATGTTGGTTGGGAATAAG
AAAGACCTGCATATGGAAAGGGTGATCAGTTATGAAGAAGGGAAAGCTTTGGCAGAATCT
TGGAATGCAGCTTTTTTGGAATCTTCTGCTAAAGAAAATCAGACTGCTGTGGATGTTTTT
CGAAGGATAATTTTGGAGGCAGAAAAAATGGACGGGGCAGCTTCACAAGGCAAGTCTTCA
TGCTCGGTGATGTGA

Protein Properties

Number of Residues

184

Molecular Weight

20497.3

Theoretical pI

5.73

Pfam Domain Function

Ras (PF00071 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>GTP-binding protein Rheb
MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVD
TAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNK
KDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRIILEAEKMDGAASQGKSS
CSVM

External Links

GenBank ID Protein

453470

UniProtKB/Swiss-Prot ID

Q15382

UniProtKB/Swiss-Prot Entry Name

RHEB_HUMAN

PDB IDs