| Identification |
|---|
| HMDB Protein ID
| CDBP03756 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ral guanine nucleotide dissociation stimulator-like 3 |
| Description
| Not Available |
| Synonyms
|
- RalGDS-like 3
|
| Gene Name
| RGL3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in signal transduction |
| Specific Function
| Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| guanyl-nucleotide exchange factor activity |
| enzyme regulator activity |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
| intracellular signal transduction |
| small gtpase mediated signal transduction |
| regulation of cell communication |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19p13.2 |
| SNPs
| RGL3 |
| Gene Sequence
|
>2133 bp
ATGGAGCGCACAGCAGGCAAAGAGCTGGCCCTGGCACCGCTGCAGGACTGGGGTGAAGAG
ACCGAGGACGGCGCGGTGTACAGTGTCTCCCTGCGGCGGCAGCGCAGTCAGCGCAGGAGC
CCGGCGGAGGGCCCCGGGGGCAGCCAGGCTCCCAGCCCCATTGCCAATACCTTCCTCCAC
TATCGAACCAGCAAGGTGAGGGTGCTGAGGGCAGCGCGCCTGGAGCGGCTGGTGGGAGAG
TTGGTGTTTGGAGACCGTGAGCAGGACCCCAGCTTCATGCCCGCCTTCCTGGCCACCTAC
CGGACCTTTGTACCCACTGCCTGCCTGCTGGGCTTTCTGCTGCCACCAATGCCACCGCCC
CCACCTCCCGGGGTAGAGATCAAGAAGACAGCGGTACAAGATCTGAGCTTCAACAAGAAC
CTGAGGGCTGTGGTGTCAGTGCTGGGCTCCTGGCTGCAGGACCACCCTCAGGATTTCCGA
GACCCCCCTGCCCATTCGGACCTGGGCAGTGTCCGAACCTTTCTGGGCTGGGCGGCCCCA
GGGAGTGCTGAGGCTCAAAAAGCAGAGAAGCTTCTGGAAGATTTTTTGGAGGAGGCTGAG
CGAGAGCAGGAAGAGGAGCCGCCTCAGGTGTGGACAGGACCTCCCAGAGTTGCCCAAACT
TCTGACCCAGACTCTTCAGAGGCCTGCGCGGAGGAAGAGGAAGGGCTCATGCCTCAAGGT
CCCCAGCTCCTGGACTTCAGCGTGGACGAGGTGGCCGAGCAGCTGACCCTCATAGACTTG
GAGCTCTTCTCCAAGGTGAGGCTCTACGAGTGCTTGGGCTCCGTGTGGTCGCAGAGGGAC
CGGCCGGGGGCTGCAGGCGCCTCCCCCACTGTGCGCGCCACCGTGGCCCAGTTCAACACC
GTGACCGGCTGTGTGCTGGGTTCCGTGCTCGGAGCACCGGGCTTGGCCGCCCCGCAGAGG
GCGCAGCGGCTGGAGAAGTGGATCCGCATCGCCCAGCGCTGCCGAGAACTGCGGAACTTC
TCCTCCTTGCGCGCCATCCTGTCCGCCCTGCAATCTAACCCCATCTACCGGCTCAAGCGC
AGCTGGGGGGCAGTGAGCCGGGAACCGCTATCTACTTTCAGGAAACTTTCGCAGATTTTC
TCCGATGAGAACAACCACCTCAGCAGCAGAGAGATTCTTTTCCAGGAGGAGGCCACTGAG
GGATCCCAAGAAGAGGACAACACCCCAGGCAGCCTGCCCTCAAAACCACCCCCAGGCCCT
GTCCCCTACCTTGGCACCTTCCTTACGGACCTGGTTATGCTGGACACAGCCCTGCCGGAT
ATGTTGGAGGGGGATCTCATTAACTTTGAGAAGAGGAGGAAGGAGTGGGAGATCCTGGCC
CGCATCCAGCAGCTGCAGAGGCGCTGTCAGAGCTACACCCTGAGCCCCCACCCGCCCATC
CTGGCTGCCCTGCATGCCCAGAACCAGCTCACCGAGGAGCAGAGCTACCGGCTCTCCCGG
GTCATTGAGCCACCAGCTGCCTCCTGCCCCAGCTCCCCACGCATCCGACGGCGGATCAGC
CTCACCAAGCGTCTCAGTGCGAAGCTTGCCCGAGAGAAAAGCTCATCACCTAGTGGGAGT
CCCGGGGACCCCTCATCCCCCACCTCCAGTGTGTCCCCAGGGTCACCCCCCTCAAGTCCT
AGAAGCAGAGATGCTCCTGCTGGCAGTCCCCCGGCCTCTCCAGGGCCCCAGGGCCCCAGC
ACCAAGCTGCCCCTGAGCCTGGACCTGCCCAGCCCCCGGCCCTTCGCTTTGCCTCTGGGC
AGCCCTCGAATCCCCCTCCCGGCGCAGCAGAGCTCGGAGGCCCGTGTCATCCGCGTCAGC
ATCGACAATGACCACGGGAACCTGTATCGAAGCATCTTGCTGACCAGTCAGGACAAAGCC
CCCAGCGTGGTCCGGCGAGCCTTGCAGAAGCACAATGTGCCCCAGCCCTGGGCCTGTGAC
TATCAGCTCTTTCAAGTCCTTCCTGGGGACCGGGTGCTCCTGATTCCTGACAATGCCAAC
GTCTTCTATGCCATGAGTCCAGTCGCCCCCAGAGACTTCATGCTGCGGCGGAAAGAGGGG
ACCCGGAACACTCTGTCTGTCTCCCCAAGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 710 |
| Molecular Weight
| 78078.5 |
| Theoretical pI
| 7.76 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ral guanine nucleotide dissociation stimulator-like 3
MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLH
YRTSKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPP
PPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAP
GSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQG
PQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNT
VTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKR
SWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGP
VPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPI
LAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGS
PGDPSSPTSSVSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRPFALPLG
SPRIPLPAQQSSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACD
YQLFQVLPGDRVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS
|
| External Links |
|---|
| GenBank ID Protein
| 239582763 |
| UniProtKB/Swiss-Prot ID
| Q3MIN7 |
| UniProtKB/Swiss-Prot Entry Name
| RGL3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001035223.2 |
| GeneCard ID
| RGL3 |
| GenAtlas ID
| RGL3 |
| HGNC ID
| HGNC:30282 |
| References |
|---|
| General References
| Not Available |