| Identification |
|---|
| HMDB Protein ID
| CDBP03752 |
| Secondary Accession Numbers
| Not Available |
| Name
| Rab11 family-interacting protein 2 |
| Description
| Not Available |
| Synonyms
|
- NRip11
- Rab11-FIP2
|
| Gene Name
| RAB11FIP2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein transport |
| Specific Function
| A Rab11 effector protein acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) |
| GO Classification
|
| Component |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| Process |
| protein transport |
| establishment of localization |
| transport |
|
| Cellular Location
|
- Cell membrane
- Peripheral membrane protein
- Peripheral membrane protein
- Recycling endosome membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 10q26.11 |
| SNPs
| RAB11FIP2 |
| Gene Sequence
|
>1539 bp
ATGATGCTGTCCGAGCAAGCCCAAAAGTGGTTTCCAACCCACGTGCAGGTCACAGTGCTC
CAAGCCAAAGATCTGAAGCCAAAAGGCAAAAGTGGTACCAATGACACATACACTATAATT
CAGCTGGGCAAGGAAAAGTACTCCACCTCTGTAGCTGAGAAAACCCTTGAGCCAGTTTGG
AAGGAGGAGGCCTCTTTCGAGCTACCTGGATTGCTAATTCAGGGAAGTCCAGAGAAATAC
ATTCTTTTCCTTATAGTTATGCACAGGTCCCTGGTGGGTCTGGATAAATTTTTAGGGCAG
GTGGCAATCAATCTCAATGACATCTTTGAGGACAAACAAAGAAGGAAAACAGAGTGGTTT
AGATTAGAATCCAAACAAGGAAAACGAATCAAAAACAGGGGTGAGATAAAGGTCAATATT
CAGTTTATGAGGAACAATATGACCGCAAGTATGTTTGACTTATCAATGAAGGACAAAACC
AGATCTCCTTTTGCAAAGTTAAAAGATAAGATGAAGGGTAGAAAAAATGATGGAACATTT
TCTGATACGTCTTCTGCAATCATTCCAAGTACTCACATGCCCGATGCCAATAGTGAATTT
TCAAGTGGTGAAATACAGATGAAATCCAAACCAAAAAAGCCTTTTCTCTTGGGTCCTCAG
CGACTCTCGTCAGCGCATTCAATGTCTGATTTATCTGGGTCCCATATGTCTTCTGAGAAA
CTGAAGGCTGGCACCATAGGTCAAACACATCTTCTCGGACACCAGTTAGATTCCTTTGGA
ACAGTTCCAGAAAGTGGAAGTCTCAAATCTCCACACAGAAGAACATTAAGCTTTGATACT
TCTAAAATGAACCAACCTGACAGCATTGTGGATGAAGGTGAATTGTGTTTCGGAAGACAA
AATGACCCATTTACAAATGTGACTGCTTCATTACCCCAAAAATTTGCAACACTGCCAAGG
AAGAAAAATCCATTTGAAGAAAGCAGCGAAACATGGGACAGCAGCATGAATTTATTTTCA
AAACCAATTGAAATAAGAAAAGAAAATAAAAGAGAGAAAAGGGAGAAAGTTAGCCTGTTT
GAAAGAGTGACTGGAAAAAAAGATAGCAGAAGATCTGATAAACTTAACAATGGGGGATCT
GATAGCCCTTGTGACTTGAAATCACCTAATGCATTTAGTGAAAATCGCCAGGACTATTTT
GATTATGAGTCAACCAATCCATTTACAGCAAAATTCAGGGCTTCAAATATAATGCCATCT
TCAAGTTTTCATATGAGTCCAACAAGCAATGAAGACCTCAGGAAAATCCCGGACAGCAAC
CCCTTTGATGCCACTGCAGGGTATCGTAGTCTGACCTATGAAGAGGTTCTACAGGAGCTG
GTGAAACACAAAGAACTCCTTAGGAGGAAAGACACCCACATCCGGGAACTCGAGGACTAC
ATCGACAACCTCCTTGTAAGGGTAATGGAAGAAACGCCCAGTATTCTCAGAGTGCCGTAT
GAACCATCCAGGAAAGCTGGCAAATTCTCTAACAGTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 512 |
| Molecular Weight
| 58278.6 |
| Theoretical pI
| 9.95 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Rab11 family-interacting protein 2
MMLSEQAQKWFPTHVQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVW
KEEASFELPGLLIQGSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWF
RLESKQGKRIKNRGEIKVNIQFMRNNMTASMFDLSMKDKTRSPFAKLKDKMKGRKNDGTF
SDTSSAIIPSTHMPDANSEFSSGEIQMKSKPKKPFLLGPQRLSSAHSMSDLSGSHMSSEK
LKAGTIGQTHLLGHQLDSFGTVPESGSLKSPHRRTLSFDTSKMNQPDSIVDEGELCFGRQ
NDPFTNVTASLPQKFATLPRKKNPFEESSETWDSSMNLFSKPIEIRKENKREKREKVSLF
ERVTGKKDSRRSDKLNNGGSDSPCDLKSPNAFSENRQDYFDYESTNPFTAKFRASNIMPS
SSFHMSPTSNEDLRKIPDSNPFDATAGYRSLTYEEVLQELVKHKELLRRKDTHIRELEDY
IDNLLVRVMEETPSILRVPYEPSRKAGKFSNS
|
| External Links |
|---|
| GenBank ID Protein
| 7662394 |
| UniProtKB/Swiss-Prot ID
| Q7L804 |
| UniProtKB/Swiss-Prot Entry Name
| RFIP2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_014904.2 |
| GeneCard ID
| RAB11FIP2 |
| GenAtlas ID
| RAB11FIP2 |
| HGNC ID
| HGNC:29152 |
| References |
|---|
| General References
| Not Available |