| Identification |
|---|
| HMDB Protein ID
| CDBP03741 |
| Secondary Accession Numbers
| Not Available |
| Name
| ELKS/Rab6-interacting/CAST family member 1 |
| Description
| Not Available |
| Synonyms
|
- ERC-1
- Rab6-interacting protein 2
|
| Gene Name
| ERC1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein transport |
| Specific Function
| Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport |
| GO Classification
|
| Component |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| Process |
| establishment of localization |
| transport |
| protein transport |
|
| Cellular Location
|
- Cytoplasm
- Golgi apparatus membrane
- Peripheral membrane protein
- Peripheral membrane protein
- Membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12p13.3 |
| SNPs
| ERC1 |
| Gene Sequence
|
>3351 bp
ATGTATGGAAGTGCCCGCTCTGTTGGGAAGGTGGAGCCGAGCAGCCAGAGCCCTGGGCGT
TCACCCAGGCTTCCACGTTCCCCTCGCTTGGGTCACCGTCGAACCAACAGTACGGGAGGG
AGTTCGGGAAGCAGTGTTGGAGGTGGCAGTGGGAAAACCCTTTCAATGGAAAATATACAA
TCTTTAAATGCTGCCTATGCCACCTCTGGCCCTATGTATCTAAGTGACCATGAAAATGTG
GGTTCAGAAACACCTAAAAGCACCATGACACTTGGCCGTTCTGGGGGACGTCTGCCTTAC
GGTGTTCGGATGACTGCTATGGGTAGTAGCCCCAATATAGCTAGCAGTGGGGTTGCTAGT
GACACCATAGCATTTGGAGAGCATCACCTCCCTCCTGTGAGTATGGCATCCACTGTACCT
CACTCCCTTCGTCAGGCGAGAGATAACACAATCATGGATCTGCAGACACAGCTGAAGGAA
GTATTAAGAGAAAATGATCTCTTGCGGAAGGATGTGGAAGTAAAGGAGAGCAAATTGAGT
TCTTCAATGAATAGCATCAAGACCTTCTGGAGCCCAGAGCTGAAGAAGGAACGAGCCCTG
AGAAAAGATGAAGCTTCCAAAATCACCATTTGGAAGGAACAGTACAGAGTTGTACAGGAG
GAAAACCAGCACATGCAGATGACAATCCAGGCTCTCCAGGATGAATTGCGGATCCAGAGG
GACCTGAATCAGCTGTTTCAGCAGGATAGTAGCAGCAGGACTGGCGAACCTTGTGTAGCA
GAGCTGACAGAGGAGAACTTTCAGAGGCTTCATGCTGAGCATGAGCGGCAGGCCAAAGAG
CTGTTTCTTCTTCGAAAGACATTGGAGGAAATGGAGCTGCGTATTGAGACTCAAAAGCAG
ACCCTAAATGCTCGGGATGAATCCATTAAGAAGCTTCTGGAAATGTTGCAGAGCAAAGGA
CTTTCTGCCAAGGCTACCGAGGAAGACCATGAGAGAACAAGACGACTGGCAGAGGCAGAG
ATGCACGTTCATCACCTAGAAAGCCTTTTGGAGCAGAAGGAAAAAGAGAACAGTATGTTG
AGAGAGGAGATGCATCGAAGGTTTGAGAATGCTCCTGATTCTGCCAAAACAAAAGCTCTG
CAAACTGTTATTGAGATGAAGGATTCAAAAATTTCCTCTATGGAGCGTGGGCTTCGAGAC
CTGGAAGAGGAAATTCAGATGCTGAAATCGAATGGTGCTTTGAGTACTGAGGAAAGGGAA
GAAGAAATGAAGCAAATGGAAGTGTATCGGAGCCATTCTAAATTTATGAAAAATAAGGTA
GAACAACTGAAGGAGGAACTAAGTTCGAAAGAGGCTCAATGGGAGGAGCTGAAAAAGAAA
GCGGCTGGTCTTCAGGCTGAGATTGGCCAGGTGAAACAGGAGCTGTCCAGAAAGGACACA
GAACTACTCGCCCTGCAGACAAAGCTAGAAACACTCACAAACCAGTTCTCAGATAGTAAA
CAGCACATTGAAGTGTTGAAGGAGTCCTTGACTGCTAAGGAGCAGAGGGCTGCCATCCTG
CAGACTGAGGTGGATGCTCTCCGATTGCGTTTGGAAGAGAAGGAAACCATGTTGAATAAA
AAGACAAAACAAATTCAGGATATGGCTGAAGAGAAGGGGACACAAGCTGGAGAGATACAT
GACCTCAAGGACATGTTGGATGTGAAGGAGCGGAAGGTTAATGTTCTTCAGAAGAAGATT
GAAAATCTTCAAGAGCAGCTTAGAGACAAGGAAAAGCAGATGAGCAGCTTGAAAGAACGG
GTCAAATCCTTGCAGGCTGACACCACCAACACTGACACTGCCTTGACAACTTTGGAGGAG
GCCCTTGCAGAGAAAGAGCGGACAATTGAACGCTTAAAGGAGCAGAGGGACAGAGATGAG
CGAGAGAAGCAAGAGGAAATTGATAACTACAAAAAAGATCTTAAAGACTTGAAGGAAAAA
GTCAGCCTGTTGCAAGGCGACCTTTCAGAGAAAGAGGCTTCACTTTTGGATCTGAAAGAG
CATGCTTCTTCTCTGGCATCCTCAGGACTGAAAAAGGACTCACGGCTTAAGACACTAGAG
ATTGCTTTGGAGCAGAAGAAGGAGGAGTGTCTGAAAATGGAATCACAATTGAAAAAGGCA
CATGAGGCAGCATTGGAAGCCAGAGCCAGTCCAGAGATGAGTGACCGAATACAGCACTTG
GAGAGAGAGATCACCAGGTACAAAGATGAATCTAGCAAGGCCCAGGCAGAAGTTGATCGA
CTCTTAGAAATCTTGAAGGAGGTGGAAAATGAGAAGAATGACAAAGATAAGAAGATAGCT
GAGTTGGAAAGGCAAGTGAAAGACCAGAATAAGAAGGTAGCAAATCTGAAGCACAAGGAA
CAGGTGGAAAAAAAGAAGAGTGCACAAATGTTAGAGGAGGCGCGACGACGGGAGGACAAT
CTCAACGACAGCTCTCAGCAGCTACAGGACAGTCTCCGTAAGAAGGATGACAGGATTGAA
GAGCTGGAAGAAGCACTAAGAGAAAGTGTACAGATAACTGCAGAGCGGGAAATGGTGCTA
GCACAAGAGGAATCAGCCAGGACCAATGCTGAAAAACAGGTGGAGGAGTTACTGATGGCC
ATGGAGAAGGTAAAGCAGGAACTAGAATCCATGAAAGCAAAGCTGTCCTCCACCCAGCAG
TCTCTGGCAGAAAAGGAAACTCACTTGACTAATCTTCGGGCAGAGAGAAGGAAACACTTA
GAGGAAGTTCTGGAGATGAAGCAAGAAGCTCTTCTGGCTGCCATTAGTGAAAAAGACGCC
AATATAGCTCTCTTGGAGCTTTCGTCCTCTAAGAAGAAGACCCAAGAGGAAGTGGCTGCC
CTGAAGCGGGAGAAGGATCGTCTGGTACAGCAGCTTAAGCAGCAGACGCAAAATCGAATG
AAGCTAATGGCCGACAACTACGAGGATGACCACTTCAAATCCTCCCATTCCAATCAAACA
AATCACAAGCCCTCCCCAGACCAGATCATCCAGCCCCTCTTAGAACTTGACCAAAATAGA
AGTAAATTAAAGTTGTACATTGGACACCTGACAACCCTCTGCCATGACCGAGACCCCCTG
ATCCTCCGTGGACTCACTCCACCAGCTTCCTATAACTTGGACGATGACCAGGCGGCTTGG
GAGAATGAGCTGCAGAAGATGACCCGGGGGCAGCTTCAGGATGAGTTAGAGAAAGGTGAA
CGGGACAATGCAGAACTGCAGGAGTTTGCCAACGCCATTCTTCAGCAGATAGCAGACCAT
TGTCCCGACATCCTAGAGCAAGTGGTCAACGCCCTGGAAGAGTCCTCTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1116 |
| Molecular Weight
| 128085.4 |
| Theoretical pI
| 5.8 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>ELKS/Rab6-interacting/CAST family member 1
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQ
SLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPYGVRMTAMGSSPNIASSGVAS
DTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQR
DLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQ
TLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEERE
EEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDT
ELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKER
VKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEK
VSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIA
ELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIE
ELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ
SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAA
LKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNR
SKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGE
RDNAELQEFANAILQQIADHCPDILEQVVNALEESS
|
| External Links |
|---|
| GenBank ID Protein
| 38045898 |
| UniProtKB/Swiss-Prot ID
| Q8IUD2 |
| UniProtKB/Swiss-Prot Entry Name
| RB6I2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_178040.2 |
| GeneCard ID
| ERC1 |
| GenAtlas ID
| ERC1 |
| HGNC ID
| HGNC:17072 |
| References |
|---|
| General References
| Not Available |