| Identification |
|---|
| HMDB Protein ID
| CDBP03731 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ran-binding protein 9 |
| Description
| Not Available |
| Synonyms
|
- BPM-L
- BPM90
- Ran-binding protein M
- RanBP7
- RanBP9
- RanBPM
|
| Gene Name
| RANBP9 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Cell cycle control, cell division, chromosome partitioning |
| Specific Function
| May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Involved in activation of androgen and glucocorticoid receptor in the presence of their cognate hormones. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6p23 |
| SNPs
| RANBP9 |
| Gene Sequence
|
>2190 bp
ATGTCCGGGCAGCCGCCGCCGCCGCCGCCGCAGCAGCAGCAACAGCAGCAGCAGCTGTCG
CCGCCACCGCCGGCGGCCTTGGCCCCAGTCTCCGGAGTCGTCCTGCCGGCGCCCCCGGCC
GTCAGCGCCGGCTCTTCTCCGGCCGGCTCGCCCGGCGGCGGTGCGGGCGGCGAAGGCTTA
GGGGCCGCGGCGGCCGCCCTGCTCCTCCACCCTCCGCCGCCGCCGCCCCCGGCCACCGCG
GCCCCGCCGCCCCCGCCGCCGCCCCCGCCTCCCCCTGCCTCAGCGGCTGCCCCCGCCAGC
GGGCCGCCCGCTCCCCCGGGCCTTGCAGCGGGCCCCGGCCCGGCTGGAGGAGCCCCGACC
CCAGCTCTGGTGGCGGGCAGCAGCGCCGCGGCCCCCTTCCCTCACGGGGACTCGGCCCTG
AACGAGCAGGAGAAGGAGTTGCAGCGGCGGCTGAAGCGTCTCTACCCGGCCGTGGACGAA
CAAGAGACGCCGCTGCCTCGGTCCTGGAGCCCGAAGGACAAGTTCAGCTACATCGGCCTC
TCTCAGAACAACCTGCGGGTGCACTACAAAGGTCATGGCAAAACCCCAAAAGATGCCGCG
TCAGTTCGAGCCACGCATCCAATACCAGCAGCCTGTGGGATTTATTATTTTGAAGTAAAA
ATTGTCAGTAAGGGAAGAGATGGTTACATGGGAATTGGTCTTTCTGCTCAAGGTGTGAAC
ATGAATAGACTACCAGGTTGGGATAAGCATTCATATGGTTACCATGGGGATGATGGACAT
TCGTTTTGTTCTTCTGGAACTGGACAACCTTATGGACCAACTTTCACTACTGGTGATGTC
ATTGGCTGTTGTGTTAATCTTATCAACAATACCTGCTTTTACACCAAGAATGGACATAGT
TTAGGTATTGCTTTCACTGACCTACCGCCAAATTTGTATCCTACTGTGGGGCTTCAAACA
CCAGGAGAAGTGGTCGATGCCAATTTTGGGCAACATCCTTTCGTGTTTGATATAGAAGAC
TATATGCGGGAGTGGAGAACCAAAATCCAGGCACAGATAGATCGATTTCCTATCGGAGAT
CGAGAAGGAGAATGGCAGACCATGATACAAAAAATGGTTTCATCTTATTTAGTCCACCAT
GGGTACTGTGCCACAGCAGAGGCCTTTGCCAGATCTACAGACCAGACCGTTCTAGAAGAA
TTAGCTTCCATTAAGAATAGACAAAGAATTCAGAAATTGGTATTAGCAGGAAGAATGGGA
GAAGCCATTGAAACAACACAACAGTTATACCCAAGTTTACTTGAAAGAAATCCTAATCTC
CTTTTCACATTAAAAGTGCGTCAGTTTATAGAAATGGTGAATGGTACAGATAGTGAAGTA
CGATGTTTGGGAGGCCGAAGTCCAAAGTCTCAAGACAGTTATCCTGTTAGTCCTCGACCT
TTTAGTAGTCCAAGTATGAGCCCCAGCCATGGAATGAATATCCACAATTTAGCATCAGGC
AAAGGAAGCACCGCACATTTTTCAGGTTTTGAAAGTTGTAGTAATGGTGTAATATCAAAT
AAAGCACATCAATCATATTGCCATAGTAATAAACACCAGTCATCCAACTTGAATGTACCA
GAACTAAACAGTATAAATATGTCAAGATCACAGCAAGTTAATAACTTCACCAGTAATGAT
GTAGACATGGAAACAGATCACTACTCCAATGGAGTTGGAGAAACTTCATCCAATGGTTTC
CTAAATGGTAGCTCTAAACATGACCACGAAATGGAAGATTGTGACACCGAAATGGAAGTT
GATTCAAGTCAGTTGAGACGCCAGTTGTGTGGAGGAAGTCAGGCCGCCATAGAAAGAATG
ATCCACTTTGGACGAGAGCTGCAAGCAATGAGTGAACAGCTAAGGAGAGACTGTGGCAAG
AACACTGCAAACAAAAAAATGTTGAAGGATGCATTCAGTCTACTAGCATATTCAGATCCC
TGGAACAGCCCAGTTGGAAATCAGCTTGACCCGATTCAGAGAGAACCTGTGTGCTCAGCT
CTTAACAGTGCAATATTAGAAACCCACAATCTGCCAAAGCAACCTCCACTTGCCCTAGCA
ATGGGACAGGCCACACAATGTCTAGGACTGATGGCTCGATCAGGAATTGGATCCTGCGCA
TTTGCCACAGTGGAAGACTACCTACATTAG
|
| Protein Properties |
|---|
| Number of Residues
| 729 |
| Molecular Weight
| 77846.7 |
| Theoretical pI
| 6.78 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ran-binding protein 9
MSGQPPPPPPQQQQQQQQLSPPPPAALAPVSGVVLPAPPAVSAGSSPAGSPGGGAGGEGL
GAAAAALLLHPPPPPPPATAAPPPPPPPPPPPASAAAPASGPPAPPGLAAGPGPAGGAPT
PALVAGSSAAAPFPHGDSALNEQEKELQRRLKRLYPAVDEQETPLPRSWSPKDKFSYIGL
SQNNLRVHYKGHGKTPKDAASVRATHPIPAACGIYYFEVKIVSKGRDGYMGIGLSAQGVN
MNRLPGWDKHSYGYHGDDGHSFCSSGTGQPYGPTFTTGDVIGCCVNLINNTCFYTKNGHS
LGIAFTDLPPNLYPTVGLQTPGEVVDANFGQHPFVFDIEDYMREWRTKIQAQIDRFPIGD
REGEWQTMIQKMVSSYLVHHGYCATAEAFARSTDQTVLEELASIKNRQRIQKLVLAGRMG
EAIETTQQLYPSLLERNPNLLFTLKVRQFIEMVNGTDSEVRCLGGRSPKSQDSYPVSPRP
FSSPSMSPSHGMNIHNLASGKGSTAHFSGFESCSNGVISNKAHQSYCHSNKHQSSNLNVP
ELNSINMSRSQQVNNFTSNDVDMETDHYSNGVGETSSNGFLNGSSKHDHEMEDCDTEMEV
DSSQLRRQLCGGSQAAIERMIHFGRELQAMSEQLRRDCGKNTANKKMLKDAFSLLAYSDP
WNSPVGNQLDPIQREPVCSALNSAILETHNLPKQPPLALAMGQATQCLGLMARSGIGSCA
FATVEDYLH
|
| External Links |
|---|
| GenBank ID Protein
| 39812378 |
| UniProtKB/Swiss-Prot ID
| Q96S59 |
| UniProtKB/Swiss-Prot Entry Name
| RANB9_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_005493.2 |
| GeneCard ID
| RANBP9 |
| GenAtlas ID
| RANBP9 |
| HGNC ID
| HGNC:13727 |
| References |
|---|
| General References
| Not Available |