| Identification |
|---|
| HMDB Protein ID
| CDBP03717 |
| Secondary Accession Numbers
| Not Available |
| Name
| PRKCA-binding protein |
| Description
| Not Available |
| Synonyms
|
- Protein interacting with C kinase 1
- Protein kinase C-alpha-binding protein
|
| Gene Name
| PICK1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. May be regulated upon PRKCA activation. May regulate ACCN3-ACCN2 heteromeric cation channel |
| GO Classification
|
| Function |
| binding |
| protein binding |
|
| Cellular Location
|
- Cytoplasm
- perinuclear region
- Cell junction
- synapse
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 22q13.1 |
| SNPs
| PICK1 |
| Gene Sequence
|
>1248 bp
ATGTTTGCAGACTTGGATTATGACATCGAAGAGGATAAACTCGGAATCCCGACTGTGCCT
GGGAAGGTGACCCTGCAGAAGGATGCTCAGAACCTGATCGGGATCAGCATTGGAGGAGGG
GCCCAGTACTGTCCCTGCCTCTATATCGTCCAGGTATTTGACAACACCCCAGCAGCCTTG
GACGGCACAGTGGCAGCTGGCGATGAGATCACCGGTGTCAATGGCAGGTCAATCAAAGGG
AAAACTAAGGTGGAGGTGGCGAAGATGATTCAGGAGGTGAAGGGGGAGGTGACCATCCAC
TACAACAAGCTGCAGGCGGACCCCAAGCAGGGCATGTCCCTGGACATTGTGTTGAAGAAA
GTCAAGCACCGGCTGGTGGAGAACATGAGTTCAGGGACCGCAGATGCTCTGGGCCTGAGC
CGGGCCATCCTGTGCAATGATGGGCTTGTCAAGAGGCTAGAGGAGCTGGAGCGGACCGCT
GAGCTATACAAAGGGATGACGGAACACACCAAGAACCTCCTACGGGCCTTTTATGAGCTG
TCGCAGACTCACCGGGCCTTTGGGGACGTGTTCTCCGTGATCGGGGTGCGGGAGCCCCAG
CCAGCTGCGAGCGAGGCTTTTGTGAAGTTCGCCGATGCCCACCGCAGCATCGAGAAGTTC
GGCATTCGGCTTCTGAAAACCATCAAGCCGATGCTGACGGATCTGAACACGTACCTCAAC
AAAGCCATCCCGGACACTCGCCTCACCATCAAGAAGTACCTGGACGTGAAGTTTGAGTAC
CTGTCGTACTGCCTGAAGGTGAAGGAGATGGATGACGAGGAATACAGCTGCATTGCCCTA
GGCGAGCCCCTTTACCGGGTGAGCACCGGCAACTATGAGTACCGCCTGATCCTGCGCTGC
CGCCAGGAGGCGCGCGCCCGCTTCTCCCAGATGCGCAAGGATGTGCTGGAGAAGATGGAG
CTGCTGGACCAGAAGCACGTCCAGGACATCGTGTTCCAGCTGCAGCGCCTCGTGTCCACC
ATGTCCAAGTACTACAACGACTGCTACGCAGTGCTGCGGGATGCCGACGTCTTCCCCATC
GAGGTAGACCTGGCGCACACCACATTGGCCTATGGCCTCAACCAGGAGGAGTTCACAGAT
GGGGAGGAGGAGGAGGAGGAGGAAGACACGGCAGCTGGGGAGCCGTCCAGGGATACACGA
GGGGCTGCTGGGCCCTTGGACAAGGGTGGAAGCTGGTGTGACTCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 415 |
| Molecular Weight
| 46599.7 |
| Theoretical pI
| 4.94 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>PRKCA-binding protein
MFADLDYDIEEDKLGIPTVPGKVTLQKDAQNLIGISIGGGAQYCPCLYIVQVFDNTPAAL
DGTVAAGDEITGVNGRSIKGKTKVEVAKMIQEVKGEVTIHYNKLQADPKQGMSLDIVLKK
VKHRLVENMSSGTADALGLSRAILCNDGLVKRLEELERTAELYKGMTEHTKNLLRAFYEL
SQTHRAFGDVFSVIGVREPQPAASEAFVKFADAHRSIEKFGIRLLKTIKPMLTDLNTYLN
KAIPDTRLTIKKYLDVKFEYLSYCLKVKEMDDEEYSCIALGEPLYRVSTGNYEYRLILRC
RQEARARFSQMRKDVLEKMELLDQKHVQDIVFQLQRLVSTMSKYYNDCYAVLRDADVFPI
EVDLAHTTLAYGLNQEEFTDGEEEEEEEDTAAGEPSRDTRGAAGPLDKGGSWCDS
|
| External Links |
|---|
| GenBank ID Protein
| 6691439 |
| UniProtKB/Swiss-Prot ID
| Q9NRD5 |
| UniProtKB/Swiss-Prot Entry Name
| PICK1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB026491 |
| GeneCard ID
| PICK1 |
| GenAtlas ID
| PICK1 |
| HGNC ID
| HGNC:9394 |
| References |
|---|
| General References
| Not Available |