| Identification |
|---|
| HMDB Protein ID
| CDBP03712 |
| Secondary Accession Numbers
| Not Available |
| Name
| Partitioning defective 6 homolog alpha |
| Description
| Not Available |
| Synonyms
|
- PAR-6
- PAR-6 alpha
- PAR-6A
- PAR6C
- TIP-40
- Tax interaction protein 40
|
| Gene Name
| PARD6A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins |
| GO Classification
|
| Function |
| binding |
| protein binding |
|
| Cellular Location
|
- Cell membrane
- Cytoplasm
- Cell junction
- Cell projection
- tight junction
- ruffle
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine |    | Not Available | | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 16q22.1 |
| SNPs
| PARD6A |
| Gene Sequence
|
>1041 bp
ATGGCCCGGCCGCAGAGGACTCCGGCGCGCAGTCCCGATAGCATCGTCGAGGTGAAGAGC
AAATTTGACGCCGAGTTCCGACGCTTCGCGCTGCCTCGCGCTTCGGTGAGCGGCTTCCAG
GAGTTCTCGCGGTTGCTGCGGGCGGTGCACCAGATCCCGGGCCTGGACGTGCTACTTGGC
TATACGGATGCTCATGGCGACCTGCTGCCCCTCACCAACGACGACAGCCTGCACCGGGCC
CTGGCCAGCGGGCCCCCGCCACTGCGCCTACTGGTGCAGAAGCGGGCAGAAGCTGACTCC
AGCGGCCTGGCTTTTGCCTCCAACTCTCTGCAGCGGCGCAAGAAAGGGCTCTTGCTGCGG
CCAGTGGCACCCCTGCGCACCCGGCCACCCTTGCTAATCAGCCTGCCCCAAGATTTCCGC
CAGGTTTCCTCAGTCATAGACGTGGACCTACTGCCTGAGACCCACCGACGGGTGCGGCTG
CACAAGCATGGTTCAGACCGCCCCCTGGGCTTCTACATCCGAGATGGCATGAGCGTGCGT
GTGGCTCCCCAGGGCCTGGAGCGGGTTCCAGGAATCTTCATCTCCCGCCTGGTACGTGGG
GGTCTGGCTGAGAGTACAGGGCTGCTGGCGGTCAGTGATGAGATCCTCGAGGTCAATGGC
ATTGAAGTAGCCGGGAAGACCTTGGACCAAGTGACGGACATGATGGTTGCCAACAGCCAT
AACCTCATTGTCACTGTCAAGCCCGCCAACCAGCGCAATAACGTGGTGCGAGGGGCATCT
GGGCGTTTGACAGGTCCTCCCTCTGCAGGGCCTGGGCCTGCTGAGCCTGATAGTGACGAT
GACAGCAGTGACCTGGTCATTGAGAACCGCCAGCCTCCCAGTTCCAATGGGCTGTCTCAG
GGGCCCCCGTGCTGGGACCTGCACCCTGGCTGCCGACATCCTGGTACCCGCAGCTCTCTG
CCCTCCCTGGATGACCAGGAGCAGGCCAGTTCTGGCTGGGGGAGTCGCATTCGAGGAGAT
GGTAGTGGCTTCAGCCTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 346 |
| Molecular Weight
| 37387.9 |
| Theoretical pI
| 9.7 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Partitioning defective 6 homolog alpha
MARPQRTPARSPDSIVEVKSKFDAEFRRFALPRASVSGFQEFSRLLRAVHQIPGLDVLLG
YTDAHGDLLPLTNDDSLHRALASGPPPLRLLVQKRAEADSSGLAFASNSLQRRKKGLLLR
PVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVR
VAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSH
NLIVTVKPANQRNNVVRGASGRLTGPPSAGPGPAEPDSDDDSSDLVIENRQPPSSNGLSQ
GPPCWDLHPGCRHPGTRSSLPSLDDQEQASSGWGSRIRGDGSGFSL
|
| External Links |
|---|
| GenBank ID Protein
| 8394417 |
| UniProtKB/Swiss-Prot ID
| Q9NPB6 |
| UniProtKB/Swiss-Prot Entry Name
| PAR6A_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_016948.2 |
| GeneCard ID
| PARD6A |
| GenAtlas ID
| PARD6A |
| HGNC ID
| HGNC:15943 |
| References |
|---|
| General References
| Not Available |