| Identification |
|---|
| HMDB Protein ID
| CDBP03710 |
| Secondary Accession Numbers
| Not Available |
| Name
| Polyadenylate-binding protein 2 |
| Description
| Not Available |
| Synonyms
|
- Nuclear poly(A)-binding protein 1
- PABII
- PABP-2
- Poly(A)-binding protein 2
- Poly(A)-binding protein II
- Polyadenylate-binding nuclear protein 1
|
| Gene Name
| PABPN1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in nucleotide binding |
| Specific Function
| Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation |
| GO Classification
|
| Function |
| binding |
| nucleotide binding |
| nucleic acid binding |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 14q11.2-q13 |
| SNPs
| PABPN1 |
| Gene Sequence
|
>921 bp
ATGGCGGCGGCGGCGGCGGCGGCAGCAGCAGCGGGGGCTGCGGGCGGTCGGGGCTCCGGG
CCGGGGCGGCGGCGCCATCTTGTGCCCGGGGCCGGTGGGGAGGCCGGGGAGGGGGCCCCG
GGGGGCGCAGGGGACTACGGGAACGGCCTGGAGTCTGAGGAACTGGAGCCTGAGGAGCTG
CTGCTGGAGCCCGAGCCGGAGCCCGAGCCCGAAGAGGAGCCGCCCCGGCCCCGCGCCCCC
CCGGGAGCTCCGGGCCCTGGGCCTGGTTCGGGAGCCCCCGGCAGCCAAGAGGAGGAGGAG
GAGCCGGGACTGGTCGAGGGTGACCCGGGGGACGGCGCCATTGAGGACCCGGAGCTGGAA
GCTATCAAAGCTCGAGTCAGGGAGATGGAGGAAGAAGCTGAGAAGCTAAAGGAGCTACAG
AACGAGGTAGAGAAGCAGATGAATATGAGTCCACCTCCAGGCAATGCTGGCCCGGTGATC
ATGTCCATTGAGGAGAAGATGGAGGCTGATGCCCGTTCCATCTATGTTGGCAATGTGGAC
TATGGTGCAACAGCAGAAGAGCTGGAAGCTCACTTTCATGGCTGTGGTTCAGTCAACCGT
GTTACCATACTGTGTGACAAATTTAGTGGCCATCCCAAAGGGTTTGCGTATATAGAGTTC
TCAGACAAAGAGTCAGTGAGGACTTCCTTGGCCTTAGATGAGTCCCTATTTAGAGGAAGG
CAAATCAAGGTGATCCCAAAACGAACCAACAGACCAGGCATCAGCACAACAGACCGGGGT
TTTCCACGAGCCCGCTACCGCGCCCGGACCACCAACTACAACAGCTCCCGCTCTCGATTC
TACAGTGGTTTTAACAGCAGGCCCCGGGGTCGCGTCTACAGGGGCCGGGCTAGAGCGACA
TCATGGTATTCCCCTTACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 306 |
| Molecular Weight
| 32748.8 |
| Theoretical pI
| 4.73 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Polyadenylate-binding protein 2
MAAAAAAAAAAGAAGGRGSGPGRRRHLVPGAGGEAGEGAPGGAGDYGNGLESEELEPEEL
LLEPEPEPEPEEEPPRPRAPPGAPGPGPGSGAPGSQEEEEEPGLVEGDPGDGAIEDPELE
AIKARVREMEEEAEKLKELQNEVEKQMNMSPPPGNAGPVIMSIEEKMEADARSIYVGNVD
YGATAEELEAHFHGCGSVNRVTILCDKFSGHPKGFAYIEFSDKESVRTSLALDESLFRGR
QIKVIPKRTNRPGISTTDRGFPRARYRARTTNYNSSRSRFYSGFNSRPRGRVYRGRARAT
SWYSPY
|
| External Links |
|---|
| GenBank ID Protein
| 2895276 |
| UniProtKB/Swiss-Prot ID
| Q86U42 |
| UniProtKB/Swiss-Prot Entry Name
| PABP2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF026029 |
| GeneCard ID
| PABPN1 |
| GenAtlas ID
| PABPN1 |
| HGNC ID
| HGNC:8565 |
| References |
|---|
| General References
| Not Available |