| Identification |
|---|
| HMDB Protein ID
| CDBP03708 |
| Secondary Accession Numbers
| Not Available |
| Name
| Oligophrenin-1 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| OPHN1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in cytoskeletal adaptor activity |
| Specific Function
| Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at post-synaptic sites. Critical for the regulation of synaptic vesicle endocytosis at pre-synaptic terminals |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Process |
| signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
|
| Cellular Location
|
- Cell junction
- synapse
- Cell projection
- Cell projection
- dendritic spine
- axon
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| OPHN1 |
| Gene Sequence
|
>2409 bp
ATGGGTCATCCCCCGCTGGAGTTCAGCGACTGCTACCTGGACAGCCCCGATTTCCGCGAG
AGGCTCAAGTGTTATGAGCAGGAACTGGAGAGGACCAACAAATTCATCAAAGACGTAATC
AAAGACGGCAACGCGCTTATCAGCGCTATGAGAAATTATTCTTCTGCTGTTCAGAAATTT
TCCCAGACGCTGCAGTCATTTCAGTTTGATTTCATTGGAGACACTCTGACTGATGATGAA
ATTAACATCGCTGAATCCTTCAAGGAATTTGCTGAATTGCTCAACGAGGTAGAAAATGAG
AGGATGATGATGGTACACAATGCTAGTGATTTGCTGATTAAACCCTTGGAAAATTTCCGG
AAGGAACAAATAGGCTTCACCAAGGAGCGGAAAAAGAAATTTGAAAAGGATGGTGAGAGG
TTTTATTCTTTACTGGATCGGCACTTACACCTGTCTTCAAAAAAGAAAGAATCTCAGTTA
CAAGAGGCAGACCTACAGGTGGACAAGGAGAGGCACAATTTTTTCGAGTCCTCTCTTGAT
TATGTTTATCAAATCCAGGAAGTTCAGGAGTCCAAGAAGTTCAATATTGTGGAGCCTGTC
TTGGCCTTTCTTCATAGTCTGTTCATTTCTAACAGCCTGACTGTGGAGCTCACACAGGAT
TTCCTCCCATACAAACAACAGCTCCAACTCAGTTTACAGAATACAAGAAATCATTTCTCC
AGTACCCGGGAAGAGATGGAAGAACTTAAGAAAAGGATGAAAGAAGCTCCCCAGACATGC
AAACTTCCAGGACAGCCAACTATTGAAGGCTATCTCTATACACAAGAGAAATGGGCTTTA
GGAATATCCTGGGTGAAATACTATTGCCAGTATGAGAAAGAGACCAAAACACTGACCATG
ACGCCTATGGAGCAGAAGCCAGGTGCTAAGCAGGGGCCCTTGGACTTAACACTGAAGTAC
TGTGTGAGAAGGAAGACGGAGTCTATCGACAAGAGGTTCTGTTTTGACATAGAAACTAAT
GAAAGGCCAGGAACCATCACTCTGCAGGCCCTTTCAGAAGCTAACAGAAGGCTATGGATG
GAAGCCATGGATGGGAAAGAACCTATCTACCACAGCCCTATAACAAAACAGCAAGAAATG
GAGCTAAATGAAGTGGGCTTCAAGTTTGTCAGGAAGTGCATCAATATTATTGAGACCAAA
GGGATCAAGACAGAAGGGTTGTACCGCACTGTGGGCAGCAATATTCAGGTTCAGAAGCTG
CTGAATGCCTTTTTTGATCCTAAATGCCCAGGAGATGTTGATTTTCATAATAGTGACTGG
GACATTAAGACAATCACCAGCTCCTTGAAATTCTACCTCAGGAATCTTTCTGAACCTGTC
ATGACCTATAGACTTCACAAAGAGCTGGTCTCTGCTGCCAAGTCTGACAACCTGGATTAC
CGCCTAGGAGCTATTCACTCCCTGGTATATAAGCTACCAGAAAAGAACCGAGAGATGCTG
GAACTTCTGATAAGACACTTGGTCAATGTGTGTGAGCACAGCAAAGAGAATCTTATGACC
CCCTCCAACATGGGAGTAATCTTTGGGCCCACCCTGATGAGAGCTCAGGAGGACACTGTG
GCCGCCATGATGAACATCAAATTCCAGAACATAGTGGTGGAAATACTAATCGAGCACTTT
GGCAAGATCTATTTAGGTCCACCTGAGGAAAGCGCTGCACCGCCAGTGCCTCCGCCTCGG
GTGACAGCAAGAAGGCACAAACCAATCACGATTTCAAAGCGCTTGCTGCGAGAAAGGACG
GTTTTCTATACTTCTTCCCTGGATGAAAGCGAAGATGAAATCCAACATCAAACACCGAAT
GGTACTATCACCAGCAGCATAGAACCCCCCAAGCCACCACAACACCCCAAACTACCTATT
CAGAGGAGTGGGGAAACTGATCCTGGGAGGAAGTCCCCAAGCAGGCCTATTTTGGATGGC
AAGTTGGAGCCCTGCCCAGAGGTGGACGTGGGGAAGTTGGTGTCTAGGCTGCAGGATGGA
GGGACCAAGATCACCCCAAAGGCCACCAATGGACCCATGCCAGGCTCTGGGCCCACCAAG
ACCCCCTCTTTCCACATAAAGAGACCAGCTCCCCGGCCCCTGGCCCACCACAAGGAGGGG
GATGCTGACAGTTTCAGCAAAGTGCGGCCTCCAGGAGAAAAGCCAACCATCATCCGCCCC
CCAGTGAGGCCCCCAGATCCTCCCTGCCGGGCAGCTACTCCCCAAAAGCCAGAACCAAAG
CCAGATATTGTGGCTGGCAATGCGGGGGAAATCACATCATCTGTGGTGGCTTCCAGGACC
AGGTTTTTTGAAACAGCTTCCCGGAAAACAGGAAGTTCTCAAGGCAGACTTCCTGGAGAT
GAAAGTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 802 |
| Molecular Weight
| 91639.9 |
| Theoretical pI
| 8.07 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Oligophrenin-1
MGHPPLEFSDCYLDSPDFRERLKCYEQELERTNKFIKDVIKDGNALISAMRNYSSAVQKF
SQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPLENFR
KEQIGFTKERKKKFEKDGERFYSLLDRHLHLSSKKKESQLQEADLQVDKERHNFFESSLD
YVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFS
STREEMEELKKRMKEAPQTCKLPGQPTIEGYLYTQEKWALGISWVKYYCQYEKETKTLTM
TPMEQKPGAKQGPLDLTLKYCVRRKTESIDKRFCFDIETNERPGTITLQALSEANRRLWM
EAMDGKEPIYHSPITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKL
LNAFFDPKCPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDY
RLGAIHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTV
AAMMNIKFQNIVVEILIEHFGKIYLGPPEESAAPPVPPPRVTARRHKPITISKRLLRERT
VFYTSSLDESEDEIQHQTPNGTITSSIEPPKPPQHPKLPIQRSGETDPGRKSPSRPILDG
KLEPCPEVDVGKLVSRLQDGGTKITPKATNGPMPGSGPTKTPSFHIKRPAPRPLAHHKEG
DADSFSKVRPPGEKPTIIRPPVRPPDPPCRAATPQKPEPKPDIVAGNAGEITSSVVASRT
RFFETASRKTGSSQGRLPGDES
|
| External Links |
|---|
| GenBank ID Protein
| 33354083 |
| UniProtKB/Swiss-Prot ID
| O60890 |
| UniProtKB/Swiss-Prot Entry Name
| OPHN1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB102656 |
| GeneCard ID
| OPHN1 |
| GenAtlas ID
| OPHN1 |
| HGNC ID
| HGNC:8148 |
| References |
|---|
| General References
| Not Available |