| Identification |
|---|
| HMDB Protein ID
| CDBP03704 |
| Secondary Accession Numbers
| Not Available |
| Name
| Nucleolar protein 8 |
| Description
| Not Available |
| Synonyms
|
- Nucleolar protein Nop132
|
| Gene Name
| NOL8 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in nucleotide binding |
| Specific Function
| Plays an essential role in the survival of diffuse-type gastric cancer cells. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells |
| GO Classification
|
| Function |
| binding |
| nucleotide binding |
| nucleic acid binding |
|
| Cellular Location
|
- Nucleus
- nucleolus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:9 |
| Locus
| 9q22.31 |
| SNPs
| NOL8 |
| Gene Sequence
|
>3504 bp
ATGAAAGTGAACAGAGAAACGAAGCGCCTTTATGTGGGTGGCCTTAGCCAGGACATTTCT
GAGGCAGACCTACAAAATCAGTTCAGCAGATTTGGAGAAGTTTCGGATGTGGAGATCATC
ACACGGAAAGATGACCAAGGAAACCCACAGAAAGTTTTTGCATATATCAACATCAGTGTA
GCAGAAGCGGACCTGAAAAAATGTATGTCTGTTTTAAATAAAACAAAATGGAAAGGTGGA
ACATTACAAATTCAACTAGCAAAAGAAAGCTTTCTGCACAGATTGGCCCAAGAGAGAGAA
GCAGCAAAAGCTAAGAAAGAAGAATCAACAACAGGTAACGCCAACTTGTTAGAAAAGACA
GGAGGAGTGGATTTCCATATGAAAGCTGTGCCAGGGACAGAAGTGCCAGGGCATAAGAAT
TGGGTTGTGAGCAAATTTGGAAGAGTCTTACCTGTTCTTCACCTTAAAAATCAACATAAA
CGTAAAATCATCAAATATGATCCCTCAAAATACTGCCACAACCTGAAGAAGATAGGGGAG
GATTTCTCAAACACCATTCCTATATCCAGCCTGACTTGGGAATTAGAAGGAGGGAATGAC
CCTATGAGTAAGAAACGGCGAGGAGAGTTCTCTGACTTTCATGGCCCTCCCAAGAAGATA
ATAAAAGTGCAGAAGGATGAGAGTTCCACTGGGTCTCTGGCCATGAGTACAAGGCCCAGG
AGGGTAATAGAGAGACCACCCTTAACACAGCAACAGGCTGCACAAAAAAGAACTTGTGAT
TCCATTACTCCTTCTAAATCATCTCCTGTACCTGTTTCTGATACTCAGAAACTTAAAAAT
CTACCTTTTAAGACTTCTGGCTTGGAAACTGCCAAGAAGAGAAACAGCATTTCTGATGAT
GATACTGATTCTGAAGATGAATTGAGAATGATGATTGCGAAAGAGGAAAACTTACAGAGA
ACTACACAACCCTCAATAAATGAATCTGAAAGTGATCCTTTTGAAGTTGTAAGGGATGAT
TTCAAATCAGGCGTTCACAAACTGCATTCTTTAATAGGTTTAGGTATCAAAAATCGTGTC
TCTTGCCATGATAGTGATGATGATATTATGAGAAATGATCGTGAGTATGACTCAGGAGAT
ACAGATGAAATTATTGCGATGAAAAAAAATGTTGCTAAGGTCAAAAACAGTACAGAATTT
TCACAAATGGAAAAATCTACGAAGAAAACTTCTTTCAAAAATAGAGAAAACTGTGAGCTT
TCTGATCACTGTATTAAACTACAAAAAAGAAAAAGCAATGTAGAGTCAGCCCTCAGTCAT
GGATTAAAGTCTCTTAATCGTAAATCTCCCTCTCACTCCAGTAGCAGTGAAGATGCTGAT
TCTGCATCAGAATTAGCTGACTCTGAAGGAGGTGAGGAGTATAATGCCATGATGAAAAAC
TGCCTTCGTGTGAATCTCACTTTAGCTGATTTGGAACAATTGGCTGGCAGTGATCTGAAG
GTTCCAAATGAAGATACTAAGAGTGATGGACCAGAAACCACCACCCAATGCAAGTTTGAC
AGAGGCTCCAAGAGCCCCAAGACTCCCACTGGCCTCCGCAGAGGCCGACAGTGTATTCGT
CCTGCGGAGATTGTGGCTTCCCTGTTAGAAGGAGAGGAGAACACCTGTGGCAAACAGAAA
CCAAAGGAAAACAATTTAAAGCCAAAATTTCAGGCTTTCAAGGGAGTAGGCTGTCTATAT
GAAAAGGAGTCAATGAAAAAATCCTTGAAAGACAGTGTTGCCTCTAACAATAAAGATCAG
AATTCCATGAAACATGAGGATCCCAGTATCATATCCATGGAAGATGGGTCCCCATATGTT
AATGGCTCATTAGGTGAAGTGACTCCATGCCAACATGCAAAGAAGGCGAATGGCCCAAAC
TATATTCAGCCTCAAAAAAGACAGACCACTTTTGAAAGCCAGGATCGCAAGGCAGTGTCC
CCTAGCAGTTCTGAAAAGAGAAGTAAGAATCCTATTTCTAGGCCATTAGAAGGTAAGAAG
TCCTTAAGTCTTAGTGCAAAGACTCACAACATAGGCTTTGACAAAGACAGCTGCCATAGT
ACCACAAAGACAGAAGCTTCACAGGAAGAGCGGTCTGATTCAAGCGGCCTCACATCTCTC
AAGAAATCACCAAAGGTCTCATCCAAGGACACTCGGGAAATCAAAACTGATTTCTCACTT
TCTATTAGTAATTCGTCAGATGTGAGTGCTAAAGATAAGCATGCTGAAGACAATGAGAAG
CGTTTGGCAGCCTTGGAAGCGAGGCAAAAAGCAAAAGAAGTGCAGAAGAAGCTGGTGCAT
AATGCTCTGGCAAATTTGGATGGTCATCCAGAGGATAAGCCAACGCACATCATCTTCGGT
TCTGACAGTGAATGTGAAACAGAGGAGACATCGACTCAGGAGCAGAGCCATCCAGGAGAG
GAATGGGTGAAAGAGTCTATGGGTAAAACATCAGGGAAGCTGTTTGATAGCAGTGATGAT
GACGAATCTGATTCTGAAGATGACAGTAATAGGTTCAAAATTAAACCTCAGTTTGAGGGC
AGAGCTGGACAGAAGCTCATGGATTTACAGTCGCACTTTGGCACCGATGACAGATTCCGC
ATGGACTCTCGATTTCTAGAAACTGACAGTGAAGAGGAACAGGAAGAGGTAAATGAAAAG
AAAACTGCTGAGGAAGAAGAGCTTGCTGAAGAAAAAAAGAAAGCCCTGAATGTTGTACAA
AGTGTTTTGCAAATCAACTTAAGCAATTCTACAAACAGAGGATCAGTAGCTGCTAAGAAA
TTTAAGGACATCATACATTATGATCCAACGAAGCAAGACCATGCCACTTACGAAAGAAAA
AGAGATGATAAGCCAAAAGAAAGTAAAGCAAAACGAAAAAAGAAAAGGGAGGAAGCTGAG
AAACTACCTGAGGTGTCTAAAGAAATGTATTATAATATTGCTATGGATCTGAAAGAAATA
TTCCAAACTACAAAATATACCAGTGAAAAGGAAGAGGGCACACCCTGGAATGAGGACTGT
GGTAAAGAGAAACCTGAGGAAATCCAGGACCCTGCAGCTCTGACCAGTGACGCTGAGCAG
CCCAGCGGGTTCACGTTCTCTTTTTTTGATTCAGACACTAAAGACATAAAGGAAGAGACC
TACAGAGTTGAAACAGTGAAACCTGGAAAGATTGTCTGGCAGGAAGACCCTCGTTTACAA
GACAGCAGTTCAGAAGAGGAAGATGTTACTGAAGAAACAGATCACAGAAACTCCAGTCCT
GGAGAAGCATCATTACTTGAGAAAGAGACCACTAGATTTTTCTTTTTCTCTAAGAATGAT
GAACGACTTCAAGGTTCTGACTTATTCTGGAGAGGAGTAGGAAGTAATATGAGCAGGAAC
TCTTGGGAGGCCAGAACAACCAACCTGCGTATGGATTGTCGAAAGAAACATAAAGACGCA
AAAAGGAAAATGAAACCAAAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 1167 |
| Molecular Weight
| 131615.5 |
| Theoretical pI
| 7.09 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Nucleolar protein 8
MKVNRETKRLYVGGLSQDISEADLQNQFSRFGEVSDVEIITRKDDQGNPQKVFAYINISV
AEADLKKCMSVLNKTKWKGGTLQIQLAKESFLHRLAQEREAAKAKKEESTTGNANLLEKT
GGVDFHMKAVPGTEVPGHKNWVVSKFGRVLPVLHLKNQHKRKIIKYDPSKYCHNLKKIGE
DFSNTIPISSLTWELEGGNDPMSKKRRGEFSDFHGPPKKIIKVQKDESSTGSLAMSTRPR
RVIERPPLTQQQAAQKRTCDSITPSKSSPVPVSDTQKLKNLPFKTSGLETAKKRNSISDD
DTDSEDELRMMIAKEENLQRTTQPSINESESDPFEVVRDDFKSGVHKLHSLIGLGIKNRV
SCHDSDDDIMRNDREYDSGDTDEIIAMKKNVAKVKNSTEFSQMEKSTKKTSFKNRENCEL
SDHCIKLQKRKSNVESALSHGLKSLNRKSPSHSSSSEDADSASELADSEGGEEYNAMMKN
CLRVNLTLADLEQLAGSDLKVPNEDTKSDGPETTTQCKFDRGSKSPKTPTGLRRGRQCIR
PAEIVASLLEGEENTCGKQKPKENNLKPKFQAFKGVGCLYEKESMKKSLKDSVASNNKDQ
NSMKHEDPSIISMEDGSPYVNGSLGEVTPCQHAKKANGPNYIQPQKRQTTFESQDRKAVS
PSSSEKRSKNPISRPLEGKKSLSLSAKTHNIGFDKDSCHSTTKTEASQEERSDSSGLTSL
KKSPKVSSKDTREIKTDFSLSISNSSDVSAKDKHAEDNEKRLAALEARQKAKEVQKKLVH
NALANLDGHPEDKPTHIIFGSDSECETEETSTQEQSHPGEEWVKESMGKTSGKLFDSSDD
DESDSEDDSNRFKIKPQFEGRAGQKLMDLQSHFGTDDRFRMDSRFLETDSEEEQEEVNEK
KTAEEEELAEEKKKALNVVQSVLQINLSNSTNRGSVAAKKFKDIIHYDPTKQDHATYERK
RDDKPKESKAKRKKKREEAEKLPEVSKEMYYNIAMDLKEIFQTTKYTSEKEEGTPWNEDC
GKEKPEEIQDPAALTSDAEQPSGFTFSFFDSDTKDIKEETYRVETVKPGKIVWQEDPRLQ
DSSSEEEDVTEETDHRNSSPGEASLLEKETTRFFFFSKNDERLQGSDLFWRGVGSNMSRN
SWEARTTNLRMDCRKKHKDAKRKMKPK
|
| External Links |
|---|
| GenBank ID Protein
| 45259447 |
| UniProtKB/Swiss-Prot ID
| Q76FK4 |
| UniProtKB/Swiss-Prot Entry Name
| NOL8_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB105104 |
| GeneCard ID
| NOL8 |
| GenAtlas ID
| NOL8 |
| HGNC ID
| HGNC:23387 |
| References |
|---|
| General References
| Not Available |