| Identification |
|---|
| HMDB Protein ID
| CDBP03703 |
| Secondary Accession Numbers
| Not Available |
| Name
| Nucleolar GTP-binding protein 2 |
| Description
| Not Available |
| Synonyms
|
- Autoantigen NGP-1
|
| Gene Name
| GNL2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in GTP binding |
| Specific Function
| GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation |
| GO Classification
|
| Component |
| intracellular |
| cell part |
| Function |
| purine nucleotide binding |
| binding |
| nucleotide binding |
| guanyl nucleotide binding |
| guanyl ribonucleotide binding |
| gtp binding |
|
| Cellular Location
|
- Nucleus
- nucleolus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p34.3 |
| SNPs
| GNL2 |
| Gene Sequence
|
>2196 bp
ATGGTGAAGCCCAAGTACAAAGGACGGAGCACCATCAACCCGTCCAAGGCCAGCACAAAC
CCAGATCGAGTGCAGGGAGCAGGAGGCCAAAACATGAGGGACCGGGCCACCATCCGGCGC
CTGAATATGTATAGGCAAAAGGAGCGCAGGAACAGTCGTGGTAAAATAATTAAACCCCTG
CAATATCAATCAACGGTGGCTTCTGGCACAGTGGCAAGAGTAGAGCCAAATATTAAATGG
TTTGGAAACACACGTGTGATTAAGCAGTCATCATTACAAAAATTTCAAGAGGAAATGGAT
ACAGTTATGAAGGATCCATACAAAGTTGTCATGAAGCAAAGCAAGTTACCAATGTCTCTT
CTCCATGATCGAATCCGGCCTCATAACTTGAAGGTGCACATTCTTGATACTGAAAGTTTT
GAAACTACATTTGGCCCTAAGTCACAGAGGAAACGACCAAACTTATTTGCAAGTGATATG
CAGTCTCTTATCGAAAATGCTGAAATGTCCACTGAGAGCTATGACCAGGGCAAGGATCGT
GATTTGGTAACTGAAGACACTGGTGTGAGAAATGAAGCTCAAGAAGAGATCTATAAAAAG
GGACAGTCCAAAAGAATATGGGGTGAGCTCTACAAGGTGATAGATTCATCAGATGTTGTA
GTTCAAGTTCTTGATGCTAGAGATCCAATGGGTACTCGTTCCCCTCACATTGAAACTTAC
CTGAAGAAGGAAAAACCTTGGAAACACCTCATTTTTGTACTTAACAAATGTGACCTTGTT
CCAACCTGGGCAACAAAACGGTGGGTTGCTGTCCTCTCCCAGGATTATCCAACACTTGCT
TTCCATGCAATCCTTACTAACCCGTTTGGCAAGGGAGCATTCATTCAGCTTCTGCGGCAG
TTTGGAAAGTTGCACACTGACAAGAAACAGATCAGTGTTGGGTTCATTGGCTATCCAAAT
GTTGGCAAGAGCTCTGTGATAAATACATTGCGTTCTAAGAAAGTTTGCAACGTGGCTCCC
ATTGCAGGTGAAACAAAGGTCTGGCAGTATATTACTTTGATGCGTCGGATATTCCTGATT
GACTGTCCAGGTGTGGTTTACCCCTCTGAGGACTCCGAGACAGACATTGTGCTAAAAGGA
GTTGTTCAAGTAGAAAAAATTAAGAGTCCTGAAGACCACATTGGTGCTGTACTTGAACGA
GCAAAGCCAGAATATATCAGCAAAACATACAAGATTGATTCTTGGGAGAATGCTGAGGAC
TTTCTTGAGAAGCTCGCTTTCCGGACTGGGAAGTTACTAAAGGGTGGAGAGCCCGACTTG
CAGACTGTGGGTAAGATGGTCCTCAATGACTGGCAGAGGGGCCGGATTCCTTTCTTTGTC
AAGCCACCCAATGCAGAGCCACTTGTGGCCCCCCAGCTTCTACCCTCCTCATCTTTGGAA
GTTGTCCCAGAAGCAGCCCAGAACAATCCAGGGGAGGAAGTCACAGAAACTGCAGGTGAA
GGGTCAGAATCCATCATTAAGGAAGAAACAGAAGAGAACAGTCACTGTGATGCTAACACA
GAGATGCAGCAGATTCTCACACGAGTTCGGCAGAACTTTGGTAAAATCAACGTGGTGCCT
CAGTTTTCTGGGGATGACCTGGTTCCTGTGGAGGTGTCAGATCTTGAGGAAGAGCTTGAG
AGCTTTTCTGATGAAGAGGAGGAGGAACAGGAGCAACAAAGAGATGATGCGGAAGAGTCT
TCCTCGGAGCCTGAGGAGGAAAATGTGGGAAACGACACCAAAGCCGTTATTAAAGCACTG
GATGAGAAGATTGCCAAATATCAGAAGTTTCTAGACAAAGCCAAAGCCAAAAAGTTTTCA
GCAGTCAGAATATCCAAGGGACTGAGTGAAAAGATATTTGCAAAACCTGAAGAACAAAGA
AAAACACTGGAAGAAGATGTAGATGACAGAGCACCTTCCAAAAAGGGAAAGAAGCGGAAG
GCACAAAGGGAAGAGGAACAGGAACATTCAAATAAAGCTCCCAGGGCGCTTACATCAAAA
GAACGGAGGCGAGCAGTACGACAGCAACGGCCGAAAAAAGTTGGTGTGCGCTACTATGAA
ACACACAACGTGAAAAATAGGAACAGGAACAAAAAGAAGACCAATGACTCAGAGGGACAG
AAACACAAACGCAAAAAATTCAGACAAAAGCAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 731 |
| Molecular Weight
| 83654.4 |
| Theoretical pI
| 9.85 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Nucleolar GTP-binding protein 2
MVKPKYKGRSTINPSKASTNPDRVQGAGGQNMRDRATIRRLNMYRQKERRNSRGKIIKPL
QYQSTVASGTVARVEPNIKWFGNTRVIKQSSLQKFQEEMDTVMKDPYKVVMKQSKLPMSL
LHDRIRPHNLKVHILDTESFETTFGPKSQRKRPNLFASDMQSLIENAEMSTESYDQGKDR
DLVTEDTGVRNEAQEEIYKKGQSKRIWGELYKVIDSSDVVVQVLDARDPMGTRSPHIETY
LKKEKPWKHLIFVLNKCDLVPTWATKRWVAVLSQDYPTLAFHASLTNPFGKGAFIQLLRQ
FGKLHTDKKQISVGFIGYPNVGKSSVINTLRSKKVCNVAPIAGETKVWQYITLMRRIFLI
DCPGVVYPSEDSETDIVLKGVVQVEKIKSPEDHIGAVLERAKPEYISKTYKIDSWENAED
FLEKLAFRTGKLLKGGEPDLQTVGKMVLNDWQRGRIPFFVKPPNAEPLVAPQLLPSSSLE
VVPEAAQNNPGEEVTETAGEGSESIIKEETEENSHCDANTEMQQILTRVRQNFGKINVVP
QFSGDDLVPVEVSDLEEELESFSDEEEEEQEQQRDDAEESSSEPEEENVGNDTKAVIKAL
DEKIAKYQKFLDKAKAKKFSAVRISKGLSEKIFAKPEEQRKTLEEDVDDRAPSKKGKKRK
AQREEEQEHSNKAPRALTSKERRRAVRQQRPKKVGVRYYETHNVKNRNRNKKKTNDSEGQ
KHKRKKFRQKQ
|
| External Links |
|---|
| GenBank ID Protein
| 12652715 |
| UniProtKB/Swiss-Prot ID
| Q13823 |
| UniProtKB/Swiss-Prot Entry Name
| NOG2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC000107 |
| GeneCard ID
| GNL2 |
| GenAtlas ID
| GNL2 |
| HGNC ID
| HGNC:29925 |
| References |
|---|
| General References
| Not Available |