Showing Protein Guanine nucleotide exchange factor DBS (CDBP03692)
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| HMDB Protein ID | CDBP03692 | |||||||||||||||||||||||
| Secondary Accession Numbers | Not Available | |||||||||||||||||||||||
| Name | Guanine nucleotide exchange factor DBS | |||||||||||||||||||||||
| Description | Not Available | |||||||||||||||||||||||
| Synonyms |
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| Gene Name | MCF2L | |||||||||||||||||||||||
| Protein Type | Enzyme | |||||||||||||||||||||||
| Biological Properties | ||||||||||||||||||||||||
| General Function | Involved in Rho guanyl-nucleotide exchange factor activity | |||||||||||||||||||||||
| Specific Function | Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus. Isoform 5 activates CDC42 | |||||||||||||||||||||||
| GO Classification |
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| Cellular Location |
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| Pathways | Not Available | |||||||||||||||||||||||
| Gene Properties | ||||||||||||||||||||||||
| Chromosome Location | Chromosome:1 | |||||||||||||||||||||||
| Locus | 13q34 | |||||||||||||||||||||||
| SNPs | MCF2L | |||||||||||||||||||||||
| Gene Sequence |
>3390 bp ATGGCCGAGAAGGGAGCATCCCGGGGAACCCTGCGGCGGCTGTGGTCACTGCCCAGGAGG CGCCGGGGAACTGCAGGGCGCTCGAGGCCAGATGAAATCATGCACCAGGACATCGTCCCG CTCTGTGCTGCCGACATCCAGGACCAGCTAAAGAAGCGCTTTGCTTACCTGTCCGGTGGG CGGGGGCAGGACGGAAGCCCGGTTATCACCTTCCCTGACTACCCGGCCTTCAGCGAGATT CCGGACAAGGAGTTCCAGAATGTCATGACCTACCTCACCAGCATCCCCAGCCTGCAGGAC GCTGGCATCGGATTCATCCTGGTGATAGACCGGCGACGGGACAAATGGACCTCCGTGAAG GCGTCCGTCCTGCGCATCGCAGCATCTTTCCCGGCAAACCTGCAGCTCGTCCTCGTGCTT CGCCCGACGGGTTTTTTCCAAAGGACTCTCTCCGACATCGCTTTCAAATTCAATAGAGAT GACTTTAAGATGAAGGTGCCGGTCATAATGCTGAGCTCCGTACCAGACTTACACGGTTAC ATCGATAAGTCGCAGCTGACCGAGGACCTGGGTGGGACCCTGGACTACTGCCACTCCCGG TGGCTGTGCCAGCGCACGGCCATCGAAAGTTTCGCCCTCATGGTGAAGCAGACGGCTCAG ATGCTGCAGTCCTTCGGGACCGAGCTGGCTGAAACAGAGCTGCCCAATGACGTCCAGTCG ACAAGCTCAGTGCTGTGTGCGCACACAGAGAAGAAGGACAAGGCGAAGGAGGATTTGAGG CTGGCACTGAAAGAGGGGCACAGTGTCCTGGAGAGCCTCAGGGAGCTGCAGGCTGAGGGC TCAGAGCCCAGTGTGAACCAGGACCAGCTTGACAACCAGGCCACCGTGCAGAGGCTCCTG GCCCAGCTGAACGAAACCGAGGCTGCCTTCGATGAGTTCTGGGCAAAGCATCAGCAGAAA CTGGAGCAGTGTCTGCAGCTCCGGCACTTTGAGCAGGGCTTCCGGGAGGTCAAAGCCATC TTGGACGCAGCGTCCCAGAAGATAGCAACCTTCACAGACATCGGCAACAGCCTGGCGCAT GTGGAGCACCTGCTGAGGGACCTGGCCAGCTTCGAGGAGAAATCAGGCGTGGCCGTGGAG AGGGCCCGGGCCCTGTCTCTGGACGGCGAGCAGCTCATTGGGAACAAGCACTACGCGGTA GACTCCATCCGCCCAAAGTGCCAGGAGCTCCGGCACCTCTGTGACCAGTTCTCTGCGGAG ATCGCAAGGAGGAGGGGGCTGCTCAGCAAGTCCCTGGAGCTGCACCGCCGCCTGGAGACG TCCATGAAGTGGTGTGATGAAGGGATTTACCTGCTGGCCTCACAACCTGTGGACAAGTGC CAGTCCCAGGACGGCGCGGAGGCTGCCCTCCAGGAAATCGAGAAGTTTTTGGAGACCGGT GCGGAAAATAAGATCCAGGAGCTCAACGCGATTTACAAGGAATACGAATCCATCCTCAAC CAAGATCTCATGGAGCACGTGCGAAAGGTCTTCCAGAAGCAGGCAAGCATGGAGGAGGTG TTCCACCGCAGGCAGGCCAGCCTGAAGAAGCTGGCGGCCAGGCAGACGCGGCCCGTGCAG CCGGTGGCCCCCAGACCCGAGGCACTGGCAAAGTCGCCCTGCCCCTCCCCAGGCATTCGG CGAGGCTCTGAGAACTCCAGCTCCGAGGGCGGTGCGCTCCGGAGAGGGCCCTACCGGAGG GCCAAGAGTGAGATGAGTGAGAGCCGGCAGGGCCGCGGCTCAGCGGGGGAGGAGGAGGAA AGCCTGGCCATCCTGCGCAGGCACGTGATGAGCGAGCTCCTGGACACAGAACGGGCCTAC GTGGAGGAGCTGCTGTGCGTCCTGGAGGGCTACGCCGCGGAGATGGATAACCCACTGATG GCTCACCTCCTGTCAACAGGCCTTCACAACAAGAAGGATGTTTTGTTTGGAAACATGGAG GAAATCTATCACTTCCACAACAGGATATTCCTCAGGGAGCTGGAAAACTACACTGACTGC CCAGAACTGGTTGGAAGATGCTTTCTGGAGAGGATGGAAGATTTCCAGATCTATGAGAAG TACTGTCAGAACAAGCCCCGCTCTGAGAGCCTGTGGAGACAGTGCTCCGACTGCCCGTTT TTCCAGGAATGCCAGAGAAAGCTGGACCACAAGCTGAGCCTGGACTCCTACCTGCTGAAG CCAGTGCAGAGGATCACCAAGTACCAGCTGCTGCTCAAGGAAATGCTGAAATACAGCAGG AACTGCGAGGGGGCTGAGGACCTGCAGGAGGCGCTGAGCTCCATCCTGGGCATCCTGAAG GCCGTGAACGACTCCATGCACCTCATCGCTATCACCGGCTATGACGGGAATCTCGGCGAC CTGGGCAAGCTGCTGATGCAGGGCTCGTTCAGCGTCTGGACCGACCACAAGAGGGGCCAC ACCAAGGTGAAGGAGCTGGCCAGGTTCAAGCCCATGCAGCGGCACCTGTTCCTGCACGAG AAGGCAGTGCTCTTCTGCAAGAAGAGGGAGGAGAATGGGGAGGGGTATGAGAAAGCTCCC TCCTACAGCTACAAGCAGTCCTTAAACATGGCTGCCGTTGGCATTACGGAGAACGTGAAG GGAGATGCTAAGAAGTTCGAGATCTGGTACAACGCGCGCGAGGAGGTCTACATCGTCCAG GCGCCAACTCCTGAGATTAAAGCCGCGTGGGTGAATGAAATTCGGAAAGTGCTGACCAGC CAGCTGCAGGCTTGTAGAGAAGCCAGCCAGCACCGGGCGCTGGAGCAGTCACAGAGCCTG CCCCTGCCGGCCCCGACCAGCACCAGTCCCTCAAGAGGAAACTCAAGGAACATCAAGAAG CTGGAAGAAAGGAAAACAGACCCCCTAAGCCTGGAGGGATACGTCAGCTCAGCGCCACTG ACAAAGCCCCCCGAAAAGGGCAAAGGTTGGAGCAAAACGTCCCACTCACTGGAGGCACCT GAGGACGACGGGGGCTGGTCAAGTGCAGAGGAGCAGATTAACTCGTCCGACGCAGAGGAG GACGGCGGGTTGGGCCCCAAGAAGCTGGTTCCAGGTAAATACACGGTCGTGGCGGACCAC GAGAAGGGAGGCCCCGATGCGCTGCGCGTGAGGAGCGGGGACGTGGTGGAGCTGGTGCAG GAGGGCGACGAGGGCCTCTGGTACGTCAGGGACCCGACCACTGGCAAGGAGGGCTGGGTG CCGGCCAGCAGCCTGTCCGTCCGGCTCGGCCCGTCCGGCTCGGCCCAGTGCCTGAGCAGC TCAGAGTCGAGCCCGGGGTCGGCCGTGCTGAGCAACTCGTCCAGCTGCAGCGAGGGCGGC CAGGCCCCCTTCTCCGACCTGCAGGGGTAG |
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| Protein Properties | ||||||||||||||||||||||||
| Number of Residues | 1137 | |||||||||||||||||||||||
| Molecular Weight | 128107.9 | |||||||||||||||||||||||
| Theoretical pI | 6.39 | |||||||||||||||||||||||
| Pfam Domain Function | ||||||||||||||||||||||||
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Guanine nucleotide exchange factor DBS MFDCWRFILCKRPGSNSYSSPQRPNEAKKEETDHQIDVSDVIRLVQDTPEATAMATDEIM HQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTS IPSLQDAGIGFILVIDRRRDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIA FKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALM VKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLR ELQAEGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGF REVKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIG NKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLAS QPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQKQ ASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSPGIRRGSENSSSEGGALR RGPYRRAKSEMSESRQGRGSAGEEEESLAILRRHVMSELLDTERAYVEELLCVLEGYAAE MDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMED FQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKE MLKYSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWT DHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVG ITENVKGDAKKFEIWYNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRAL EQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTS HSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPKKLVPGKYTVVADHEKGGPDALRVRSGD VVELVQEGDEGLWYVRDPTTGKEGWVPASSLSVRLGPSGSAQCLSSSGKAHVPRAHP |
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| External Links | ||||||||||||||||||||||||
| GenBank ID Protein | 163644323 | |||||||||||||||||||||||
| UniProtKB/Swiss-Prot ID | O15068 | |||||||||||||||||||||||
| UniProtKB/Swiss-Prot Entry Name | MCF2L_HUMAN | |||||||||||||||||||||||
| PDB IDs | ||||||||||||||||||||||||
| GenBank Gene ID | NM_024979 | |||||||||||||||||||||||
| GeneCard ID | MCF2L | |||||||||||||||||||||||
| GenAtlas ID | MCF2L | |||||||||||||||||||||||
| HGNC ID | HGNC:14576 | |||||||||||||||||||||||
| References | ||||||||||||||||||||||||
| General References | Not Available | |||||||||||||||||||||||