| Identification |
|---|
| HMDB Protein ID
| CDBP03692 |
| Secondary Accession Numbers
| Not Available |
| Name
| Guanine nucleotide exchange factor DBS |
| Description
| Not Available |
| Synonyms
|
- DBL's big sister
- MCF2-transforming sequence-like protein
|
| Gene Name
| MCF2L |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in Rho guanyl-nucleotide exchange factor activity |
| Specific Function
| Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus. Isoform 5 activates CDC42 |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| small gtpase regulator activity |
| ras guanyl-nucleotide exchange factor activity |
| rho guanyl-nucleotide exchange factor activity |
| enzyme regulator activity |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| guanyl-nucleotide exchange factor activity |
| Process |
| regulation of ras protein signal transduction |
| regulation of rho protein signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| intracellular signaling pathway |
| signaling |
| signaling pathway |
| regulation of cell communication |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
|
| Cellular Location
|
- Cell membrane
- Cytoplasm
- Peripheral membrane protein
- Cytoplasmic side
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 13q34 |
| SNPs
| MCF2L |
| Gene Sequence
|
>3390 bp
ATGGCCGAGAAGGGAGCATCCCGGGGAACCCTGCGGCGGCTGTGGTCACTGCCCAGGAGG
CGCCGGGGAACTGCAGGGCGCTCGAGGCCAGATGAAATCATGCACCAGGACATCGTCCCG
CTCTGTGCTGCCGACATCCAGGACCAGCTAAAGAAGCGCTTTGCTTACCTGTCCGGTGGG
CGGGGGCAGGACGGAAGCCCGGTTATCACCTTCCCTGACTACCCGGCCTTCAGCGAGATT
CCGGACAAGGAGTTCCAGAATGTCATGACCTACCTCACCAGCATCCCCAGCCTGCAGGAC
GCTGGCATCGGATTCATCCTGGTGATAGACCGGCGACGGGACAAATGGACCTCCGTGAAG
GCGTCCGTCCTGCGCATCGCAGCATCTTTCCCGGCAAACCTGCAGCTCGTCCTCGTGCTT
CGCCCGACGGGTTTTTTCCAAAGGACTCTCTCCGACATCGCTTTCAAATTCAATAGAGAT
GACTTTAAGATGAAGGTGCCGGTCATAATGCTGAGCTCCGTACCAGACTTACACGGTTAC
ATCGATAAGTCGCAGCTGACCGAGGACCTGGGTGGGACCCTGGACTACTGCCACTCCCGG
TGGCTGTGCCAGCGCACGGCCATCGAAAGTTTCGCCCTCATGGTGAAGCAGACGGCTCAG
ATGCTGCAGTCCTTCGGGACCGAGCTGGCTGAAACAGAGCTGCCCAATGACGTCCAGTCG
ACAAGCTCAGTGCTGTGTGCGCACACAGAGAAGAAGGACAAGGCGAAGGAGGATTTGAGG
CTGGCACTGAAAGAGGGGCACAGTGTCCTGGAGAGCCTCAGGGAGCTGCAGGCTGAGGGC
TCAGAGCCCAGTGTGAACCAGGACCAGCTTGACAACCAGGCCACCGTGCAGAGGCTCCTG
GCCCAGCTGAACGAAACCGAGGCTGCCTTCGATGAGTTCTGGGCAAAGCATCAGCAGAAA
CTGGAGCAGTGTCTGCAGCTCCGGCACTTTGAGCAGGGCTTCCGGGAGGTCAAAGCCATC
TTGGACGCAGCGTCCCAGAAGATAGCAACCTTCACAGACATCGGCAACAGCCTGGCGCAT
GTGGAGCACCTGCTGAGGGACCTGGCCAGCTTCGAGGAGAAATCAGGCGTGGCCGTGGAG
AGGGCCCGGGCCCTGTCTCTGGACGGCGAGCAGCTCATTGGGAACAAGCACTACGCGGTA
GACTCCATCCGCCCAAAGTGCCAGGAGCTCCGGCACCTCTGTGACCAGTTCTCTGCGGAG
ATCGCAAGGAGGAGGGGGCTGCTCAGCAAGTCCCTGGAGCTGCACCGCCGCCTGGAGACG
TCCATGAAGTGGTGTGATGAAGGGATTTACCTGCTGGCCTCACAACCTGTGGACAAGTGC
CAGTCCCAGGACGGCGCGGAGGCTGCCCTCCAGGAAATCGAGAAGTTTTTGGAGACCGGT
GCGGAAAATAAGATCCAGGAGCTCAACGCGATTTACAAGGAATACGAATCCATCCTCAAC
CAAGATCTCATGGAGCACGTGCGAAAGGTCTTCCAGAAGCAGGCAAGCATGGAGGAGGTG
TTCCACCGCAGGCAGGCCAGCCTGAAGAAGCTGGCGGCCAGGCAGACGCGGCCCGTGCAG
CCGGTGGCCCCCAGACCCGAGGCACTGGCAAAGTCGCCCTGCCCCTCCCCAGGCATTCGG
CGAGGCTCTGAGAACTCCAGCTCCGAGGGCGGTGCGCTCCGGAGAGGGCCCTACCGGAGG
GCCAAGAGTGAGATGAGTGAGAGCCGGCAGGGCCGCGGCTCAGCGGGGGAGGAGGAGGAA
AGCCTGGCCATCCTGCGCAGGCACGTGATGAGCGAGCTCCTGGACACAGAACGGGCCTAC
GTGGAGGAGCTGCTGTGCGTCCTGGAGGGCTACGCCGCGGAGATGGATAACCCACTGATG
GCTCACCTCCTGTCAACAGGCCTTCACAACAAGAAGGATGTTTTGTTTGGAAACATGGAG
GAAATCTATCACTTCCACAACAGGATATTCCTCAGGGAGCTGGAAAACTACACTGACTGC
CCAGAACTGGTTGGAAGATGCTTTCTGGAGAGGATGGAAGATTTCCAGATCTATGAGAAG
TACTGTCAGAACAAGCCCCGCTCTGAGAGCCTGTGGAGACAGTGCTCCGACTGCCCGTTT
TTCCAGGAATGCCAGAGAAAGCTGGACCACAAGCTGAGCCTGGACTCCTACCTGCTGAAG
CCAGTGCAGAGGATCACCAAGTACCAGCTGCTGCTCAAGGAAATGCTGAAATACAGCAGG
AACTGCGAGGGGGCTGAGGACCTGCAGGAGGCGCTGAGCTCCATCCTGGGCATCCTGAAG
GCCGTGAACGACTCCATGCACCTCATCGCTATCACCGGCTATGACGGGAATCTCGGCGAC
CTGGGCAAGCTGCTGATGCAGGGCTCGTTCAGCGTCTGGACCGACCACAAGAGGGGCCAC
ACCAAGGTGAAGGAGCTGGCCAGGTTCAAGCCCATGCAGCGGCACCTGTTCCTGCACGAG
AAGGCAGTGCTCTTCTGCAAGAAGAGGGAGGAGAATGGGGAGGGGTATGAGAAAGCTCCC
TCCTACAGCTACAAGCAGTCCTTAAACATGGCTGCCGTTGGCATTACGGAGAACGTGAAG
GGAGATGCTAAGAAGTTCGAGATCTGGTACAACGCGCGCGAGGAGGTCTACATCGTCCAG
GCGCCAACTCCTGAGATTAAAGCCGCGTGGGTGAATGAAATTCGGAAAGTGCTGACCAGC
CAGCTGCAGGCTTGTAGAGAAGCCAGCCAGCACCGGGCGCTGGAGCAGTCACAGAGCCTG
CCCCTGCCGGCCCCGACCAGCACCAGTCCCTCAAGAGGAAACTCAAGGAACATCAAGAAG
CTGGAAGAAAGGAAAACAGACCCCCTAAGCCTGGAGGGATACGTCAGCTCAGCGCCACTG
ACAAAGCCCCCCGAAAAGGGCAAAGGTTGGAGCAAAACGTCCCACTCACTGGAGGCACCT
GAGGACGACGGGGGCTGGTCAAGTGCAGAGGAGCAGATTAACTCGTCCGACGCAGAGGAG
GACGGCGGGTTGGGCCCCAAGAAGCTGGTTCCAGGTAAATACACGGTCGTGGCGGACCAC
GAGAAGGGAGGCCCCGATGCGCTGCGCGTGAGGAGCGGGGACGTGGTGGAGCTGGTGCAG
GAGGGCGACGAGGGCCTCTGGTACGTCAGGGACCCGACCACTGGCAAGGAGGGCTGGGTG
CCGGCCAGCAGCCTGTCCGTCCGGCTCGGCCCGTCCGGCTCGGCCCAGTGCCTGAGCAGC
TCAGAGTCGAGCCCGGGGTCGGCCGTGCTGAGCAACTCGTCCAGCTGCAGCGAGGGCGGC
CAGGCCCCCTTCTCCGACCTGCAGGGGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1137 |
| Molecular Weight
| 128107.9 |
| Theoretical pI
| 6.39 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Guanine nucleotide exchange factor DBS
MFDCWRFILCKRPGSNSYSSPQRPNEAKKEETDHQIDVSDVIRLVQDTPEATAMATDEIM
HQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTS
IPSLQDAGIGFILVIDRRRDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIA
FKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALM
VKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLR
ELQAEGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGF
REVKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIG
NKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLAS
QPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQKQ
ASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSPGIRRGSENSSSEGGALR
RGPYRRAKSEMSESRQGRGSAGEEEESLAILRRHVMSELLDTERAYVEELLCVLEGYAAE
MDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMED
FQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKE
MLKYSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWT
DHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVG
ITENVKGDAKKFEIWYNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRAL
EQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTS
HSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPKKLVPGKYTVVADHEKGGPDALRVRSGD
VVELVQEGDEGLWYVRDPTTGKEGWVPASSLSVRLGPSGSAQCLSSSGKAHVPRAHP
|
| External Links |
|---|
| GenBank ID Protein
| 163644323 |
| UniProtKB/Swiss-Prot ID
| O15068 |
| UniProtKB/Swiss-Prot Entry Name
| MCF2L_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_024979 |
| GeneCard ID
| MCF2L |
| GenAtlas ID
| MCF2L |
| HGNC ID
| HGNC:14576 |
| References |
|---|
| General References
| Not Available |