Cannabis Compound Database: Showing Protein NF-kappa-B inhibitor-interacting Ras-like protein 1 (CDBP03686)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP03686

Secondary Accession Numbers

Not Available

Name

NF-kappa-B inhibitor-interacting Ras-like protein 1

Description

Not Available

Synonyms

I-kappa-B-interacting Ras-like protein 1
Kappa B-Ras protein 1
KappaB-Ras1

Gene Name

NKIRAS1

Protein Type

Enzyme

Biological Properties

General Function

Involved in GTP binding

Specific Function

Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB

GO Classification

Function
gtp binding
purine nucleotide binding
binding
nucleotide binding
guanyl nucleotide binding
guanyl ribonucleotide binding
Process
biological regulation
regulation of biological process
regulation of cellular process
signal transduction
intracellular signal transduction
small gtpase mediated signal transduction

Cellular Location

Cytoplasm

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:3

Locus

3p24.2

SNPs

NKIRAS1

Gene Sequence

>579 bp
ATGGGAAAGGGCTGCAAGGTTGTGGTTTGTGGATTGTTATCTGTGGGGAAAACTGCAATT
TTGGAGCAGCTCCTTTATGGAAATCATACTATTGGAATGGAAGATTGCGAAACAATGGAA
GATGTATACATGGCTTCAGTAGAAACAGACCGAGGAGTAAAAGAACAGTTACATCTTTAT
GACACCAGAGGTCTACAGGAAGGCGTGGAGCTGCCAAAGCATTATTTTTCATTTGCTGAT
GGCTTCGTTCTTGTGTACAGTGTGAATAACCTTGAATCCTTTCAAAGAGTGGAGCTTCTG
AAGAAAGAAATCGATAAGTTCAAAGACAAAAAAGAGGTAGCAATTGTGGTATTAGGAAAC
AAAATCGACCTTTCTGAGCAGAGACAAGTGGACGCTGAAGTGGCACAGCAGTGGGCAAAA
AGTGAGAAAGTAAGACTGTGGGAGGTGACTGTTACAGATCGGAAAACTCTGATTGAACCA
TTCACTTTATTAGCCAGTAAACTTTCTCAACCCCAGAGCAAATCAAGCTTTCCTTTGCCT
GGGAGGAAAAACAAAGGGAACTCTAATTCTGAGAACTAA

Protein Properties

Number of Residues

192

Molecular Weight

21642.7

Theoretical pI

6.28

Pfam Domain Function

Ras (PF00071 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>NF-kappa-B inhibitor-interacting Ras-like protein 1
MGKGCKVVVCGLLSVGKTAILEQLLYGNHTIGMEDCETMEDVYMASVETDRGVKEQLHLY
DTRGLQEGVELPKHYFSFADGFVLVYSVNNLESFQRVELLKKEIDKFKDKKEVAIVVLGN
KIDLSEQRQVDAEVAQQWAKSEKVRLWEVTVTDRKTLIEPFTLLASKLSQPQSKSSFPLP
GRKNKGNSNSEN

External Links

GenBank ID Protein

7008402

UniProtKB/Swiss-Prot ID

Q9NYS0

UniProtKB/Swiss-Prot Entry Name

KBRS1_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF229839

GeneCard ID