Identification |
HMDB Protein ID
| CDBP03632 |
Secondary Accession Numbers
| Not Available |
Name
| Guanylate-binding protein 6 |
Description
| Not Available |
Synonyms
|
- GBP-6
- GTP-binding protein 6
- Guanine nucleotide-binding protein 6
|
Gene Name
| GBP6 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in GTPase activity |
Specific Function
| Binds GTP, GDP and GMP |
GO Classification
|
Function |
guanyl nucleotide binding |
guanyl ribonucleotide binding |
gtp binding |
gtpase activity |
nucleoside-triphosphatase activity |
hydrolase activity, acting on acid anhydrides |
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
pyrophosphatase activity |
purine nucleotide binding |
binding |
nucleotide binding |
catalytic activity |
hydrolase activity |
|
Cellular Location
|
- Cytoplasmic
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 1p22.2 |
SNPs
| GBP6 |
Gene Sequence
|
>1902 bp
ATGGAATCTGGACCCAAAATGTTGGCCCCCGTTTGCCTGGTGGAAAATAACAATGAGCAG
CTATTGGTGAACCAGCAAGCTATACAGATTCTTGAAAAGATTTCTCAGCCAGTGGTGGTG
GTGGCCATTGTAGGACTGTACCGTACAGGGAAATCCTACTTGATGAACCATCTGGCAGGA
CAGAATCATGGCTTCCCTCTGGGCTCCACGGTGCAGTCTGAAACCAAGGGCATCTGGATG
TGGTGCGTGCCCCACCCATCCAAGCCAAACCACACCCTGGTCCTTCTGGACACCGAAGGT
CTGGGCGATGTGGAAAAGGGTGACCCTAAGAATGACTCCTGGATCTTTGCCCTGGCTGTG
CTCCTGTGCAGCACCTTTGTCTACAACAGCATGAGCACCATCAACCACCAGGCCCTGGAG
CAGCTGCATTATGTGACGGAGCTCACAGAACTAATTAAGGCAAAGTCCTCCCCAAGGCCT
GATGGAGTAGAAGATTCCACAGAGTTTGTGAGTTTCTTCCCAGACTTTCTTTGGACAGTA
CGGGATTTCACTCTGGAGCTGAAGTTGAACGGTCACCCTATCACAGAAGATGAATACCTG
GAGAATGCCTTGAAGCTGATTCAAGGCAATAATCCCAGAGTTCAAACATCCAATTTTCCC
AGGGAGTGCATCAGGCGTTTCTTTCCAAAACGGAAGTGTTTCGTCTTTGACCGGCCAACA
AATGACAAAGACCTTCTAGCCAATATTGAGAAGGTGTCAGAAAAGCAACTGGATCCCAAA
TTCCAGGAACAAACAAACATTTTCTGTTCTTACATCTTCACTCATGCAAGAACCAAGACC
CTCAGGGAGGGAATCACAGTCACTGGGAATCGTCTGGGAACTCTGGCAGTGACTTATGTA
GAGGCCATCAACAGTGGAGCAGTGCCTTGTCTGGAGAATGCAGTGATAACTCTGGCCCAG
CGTGAGAACTCAGCGGCCGTGCAGAGGGCAGCTGACTACTACAGCCAGCAGATGGCCCAG
CGAGTGAAGCTCCCCACAGACACGCTCCAGGAGCTGCTGGACATGCATGCGGCCTGTGAG
AGGGAAGCCATTGCAATCTTCATGGAGCACTCCTTCAAGGATGAAAATCAGGAATTCCAG
AAGAAGTTCATGGAAACCACAATGAATAAGAAGGGGGATTTCTTGCTGCAGAATGAAGAG
TCATCTGTTCAATACTGCCAGGCTAAACTCAATGAGCTCTCAAAGGGACTAATGGAAAGT
ATCTCAGCAGGAAGTTTCTCTGTTCCTGGAGGGCACAAGCTCTACATGGAAACAAAGGAA
AGGATTGAACAGGACTATTGGCAAGTTCCCAGGAAAGGAGTAAAGGCAAAAGAGGTCTTC
CAGAGGTTCCTGGAGTCACAGATGGTGATAGAGGAATCCATCTTGCAGTCAGATAAAGCC
CTCACTGATAGAGAGAAGGCAGTAGCAGTGGATCGGGCCAAGAAGGAGGCAGCTGAGAAG
GAACAGGAACTTTTAAAACAGAAATTACAGGAGCAGCAGCAACAGATGGAGGCTCAAGAT
AAGAGTCGCAAGGAAAACATAGCCCAACTGAAGGAGAAGCTGCAGATGGAGAGAGAACAC
CTACTGAGAGAGCAGATTATGATGTTGGAGCACACGCAGAAGGTCCAAAATGATTGGCTT
CATGAAGGATTTAAGAAGAAGTATGAGGAGATGAATGCAGAGATAAGTCAATTTAAACGT
ATGATTGATACTACAAAAAATGATGATACTCCCTGGATTGCACGAACCTTGGACAACCTT
GCCGATGAGCTAACTGCAATATTGTCTGCTCCTGCTAAATTAATTGGTCATGGTGTCAAA
GGTGTGAGCTCACTCTTTAAAAAGCATAAGCTCCCCTTTTAA
|
Protein Properties |
Number of Residues
| 633 |
Molecular Weight
| 72426.3 |
Theoretical pI
| 6.32 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Guanylate-binding protein 6
MESGPKMLAPVCLVENNNEQLLVNQQAIQILEKISQPVVVVAIVGLYRTGKSYLMNHLAG
QNHGFPLGSTVQSETKGIWMWCVPHPSKPNHTLVLLDTEGLGDVEKGDPKNDSWIFALAV
LLCSTFVYNSMSTINHQALEQLHYVTELTELIKAKSSPRPDGVEDSTEFVSFFPDFLWTV
RDFTLELKLNGHPITEDEYLENALKLIQGNNPRVQTSNFPRECIRRFFPKRKCFVFDRPT
NDKDLLANIEKVSEKQLDPKFQEQTNIFCSYIFTHARTKTLREGITVTGNRLGTLAVTYV
EAINSGAVPCLENAVITLAQRENSAAVQRAADYYSQQMAQRVKLPTDTLQELLDMHAACE
REAIAIFMEHSFKDENQEFQKKFMETTMNKKGDFLLQNEESSVQYCQAKLNELSKGLMES
ISAGSFSVPGGHKLYMETKERIEQDYWQVPRKGVKAKEVFQRFLESQMVIEESILQSDKA
LTDREKAVAVDRAKKEAAEKEQELLKQKLQEQQQQMEAQDKSRKENIAQLKEKLQMEREH
LLREQIMMLEHTQKVQNDWLHEGFKKKYEEMNAEISQFKRMIDTTKNDDTPWIARTLDNL
ADELTAILSAPAKLIGHGVKGVSSLFKKHKLPF
|
External Links |
GenBank ID Protein
| 157671915 |
UniProtKB/Swiss-Prot ID
| Q6ZN66 |
UniProtKB/Swiss-Prot Entry Name
| GBP6_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| NM_198460.2 |
GeneCard ID
| GBP6 |
GenAtlas ID
| GBP6 |
HGNC ID
| HGNC:25395 |
References |
General References
| Not Available |