Showing Protein Interferon-induced guanylate-binding protein 2 (CDBP03629)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP03629
Secondary Accession Numbers Not Available
Name Interferon-induced guanylate-binding protein 2
Description Not Available
Synonyms
  1. GBP-2
  2. GTP-binding protein 2
  3. Guanine nucleotide-binding protein 2
  4. HuGBP-2
Gene Name GBP2
Protein Type Enzyme
Biological Properties
General Function Involved in GTPase activity
Specific Function Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product
GO Classification
Function
nucleotide binding
catalytic activity
hydrolase activity
guanyl nucleotide binding
guanyl ribonucleotide binding
gtp binding
gtpase activity
nucleoside-triphosphatase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
pyrophosphatase activity
purine nucleotide binding
binding
Cellular Location
  1. Cell membrane
  2. Lipid-anchor
  3. Cytoplasmic side (Potential)
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 1p22.2
SNPs GBP2
Gene Sequence 
>1776 bp
ATGGCTCCAGAGATCAACTTGCCGGGCCCAATGAGCCTCATTGATAACACTAAAGGGCAG
CTGGTGGTGAATCCAGAAGCTCTGAAGATCCTATCTGCAATTACGCAGCCTGTGGTGGTG
GTGGCGATTGTGGGCCTCTATCGCACAGGCAAATCCTACCTGATGAACAAGCTGGCTGGG
AAGAAAAACGGCTTCTCTCTAGGCTCCACAGTGAAGTCTCACACCAAGGGAATCTGGATG
TGGTGTGTGCCTCATCCCAAGAAGCCAGAACACACCCTAGTTCTGCTCGACACTGAGGGC
CTGGGAGATATAGAGAAGGGTGACAATGAGAATGACTCCTGGATCTTTGCCTTGGCCATC
CTCCTGAGCAGCACCTTCGTGTACAATAGCATGGGAACCATCAACCAGCAGGCCATGGAC
CAACTTCACTATGTGACAGAGCTGACAGATCGAATCAAGGCAAACTCCTCACCTGGTAAC
AATTCTGTAGACGACTCAGCTGACTTTGTGAGCTTTTTTCCAGCATTTGTGTGGACTCTC
AGAGATTTCACCCTGGAACTGGAAGTAGATGGAGAACCCATCACTGCTGATGACTACTTG
GAGCTTTCGCTAAAGCTAAGAAAAGGTACTGATAAGAAAAGTAAAAGCTTTAATGATCCT
CGGTTGTGCATCCGAAAGTTCTTCCCCAAGAGGAAGTGCTTCGTCTTCGATTGGCCCGCT
CCTAAGAAGTACCTTGCTCACCTAGAGCAGCTAAAGGAGGAAGAGCTGAACCCTGATTTC
ATAGAACAAGTTGCAGAATTTTGTTCCTACATCCTCAGCCATTCCAATGTCAAGACTCTT
TCAGGTGGCATTCCAGTCAATGGGCCTCGTCTAGAGAGCCTGGTGCTGACCTACGTCAAT
GCCATCAGCAGTGGGGATCTACCCTGCATGGAGAACGCAGTCCTGGCCTTGGCCCAGATA
GAGAACTCAGCCGCAGTGGAAAAGGCTATTGCCCACTATGAACAGCAGATGGGCCAGAAG
GTGCAGCTGCCCACGGAAACCCTCCAGGAGCTGCTGGACCTGCACAGGGACAGTGAGAGA
GAGGCCATTGAAGTCTTCATGAAGAACTCTTTCAAGGATGTGGACCAAATGTTCCAGAGG
AAATTAGGGGCCCAGTTGGAAGCAAGGCGAGATGACTTTTGTAAGCAGAATTCCAAAGCA
TCATCAGATTGTTGCATGGCTTTACTTCAGGATATATTTGGCCCTTTAGAAGAAGATGTC
AAGCAGGGAACATTTTCTAAACCAGGAGGTTACCGTCTCTTTACTCAGAAGCTGCAGGAG
CTGAAGAATAAGTACTACCAGGTGCCAAGGAAGGGGATACAGGCCAAAGAGGTGCTGAAA
AAATATTTGGAGTCCAAGGAGGATGTGGCTGATGCACTTCTACAGACTGATCAGTCACTC
TCAGAAAAGGAAAAAGCGATTGAAGTGGAACGTATAAAGGCTGAATCTGCAGAAGCTGCA
AAGAAAATGTTGGAGGAAATACAAAAGAAGAATGAGGAGATGATGGAACAGAAAGAGAAG
AGTTATCAGGAACATGTGAAACAATTGACTGAGAAGATGGAGAGGGACAGGGCCCAGTTA
ATGGCAGAGCAAGAGAAGACCCTCGCTCTTAAACTTCAGGAACAGGAACGCCTTCTCAAG
GAGGGATTCGAGAATGAGAGCAAGAGACTTCAAAAAGACATATGGGATATCCAGATGAGA
AGCAAATCATTGGAGCCAATATGTAACATACTCTAA
Protein Properties
Number of Residues 591
Molecular Weight 67208.5
Theoretical pI 5.41
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Interferon-induced guanylate-binding protein 2
MAPEINLPGPMSLIDNTKGQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
KKNGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAI
LLSSTFVYNSMGTINQQAMDQLHYVTELTDRIKANSSPGNNSVDDSADFVSFFPAFVWTL
RDFTLELEVDGEPITADDYLELSLKLRKGTDKKSKSFNDPRLCIRKFFPKRKCFVFDWPA
PKKYLAHLEQLKEEELNPDFIEQVAEFCSYILSHSNVKTLSGGIPVNGPRLESLVLTYVN
AISSGDLPCMENAVLALAQIENSAAVEKAIAHYEQQMGQKVQLPTETLQELLDLHRDSER
EAIEVFMKNSFKDVDQMFQRKLGAQLEARRDDFCKQNSKASSDCCMALLQDIFGPLEEDV
KQGTFSKPGGYRLFTQKLQELKNKYYQVPRKGIQAKEVLKKYLESKEDVADALLQTDQSL
SEKEKAIEVERIKAESAEAAKKMLEEIQKKNEEMMEQKEKSYQEHVKQLTEKMERDRAQL
MAEQEKTLALKLQEQERLLKEGFENESKRLQKDIWDIQMRSKSLEPICNIL
GenBank ID Protein 38327558
UniProtKB/Swiss-Prot ID P32456
UniProtKB/Swiss-Prot Entry Name GBP2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_004120.3
GeneCard ID GBP2
GenAtlas ID GBP2
HGNC ID HGNC:4183
References
General References Not Available