| Identification |
|---|
| HMDB Protein ID
| CDBP03584 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ribosome-releasing factor 2, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- EF-G2mt
- Elongation factor G 2, mitochondrial
- Elongation factor G2
- RRF2mt
- hEFG2
- mEF-G 2
|
| Gene Name
| GFM2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in GTPase activity |
| Specific Function
| Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in protein elongation and does not promote the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome |
| GO Classification
|
| Function |
| binding |
| nucleotide binding |
| catalytic activity |
| hydrolase activity |
| guanyl nucleotide binding |
| guanyl ribonucleotide binding |
| gtp binding |
| gtpase activity |
| nucleoside-triphosphatase activity |
| hydrolase activity, acting on acid anhydrides |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| pyrophosphatase activity |
| purine nucleotide binding |
|
| Cellular Location
|
- Mitochondrion
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q13 |
| SNPs
| GFM2 |
| Gene Sequence
|
>2340 bp
ATGTTGACCAACTTGAGGATATTTGCAATGAGTCATCAGACAATACCCAGTGTGTATATT
AATAATATATGCTGCTATAAAATAAGAGCAAGTTTAAAAAGATTAAAGCCACATGTGCCG
CTTGGAAGAAATTGCAGTTCTCTACCAGGCTTAATAGGAAATGATATCAAATCCCTTCAT
TCCATCATCAATCCTCCCATAGCTAAAATCCGTAATATTGGAATTATGGCTCATATTGAT
GCAGGCAAAACTACCACCACAGAAAGAATATTGTACTATTCCGGATATACAAGATCACTG
GGAGATGTTGATGATGGAGACACAGTGACAGATTTCATGGCCCAAGAGCGAGAAAGAGGC
ATTACTATTCAATCAGCTGCTGTTACATTTGATTGGAAAGGTTATAGAGTCAATCTAATT
GATACACCAGGTCATGTGGACTTTACCTTGGAGGTTGAGCGGTGCCTAAGAGTGTTGGAT
GGTGCAGTGGCTGTATTTGATGCCTCTGCTGGTGTAGAGGCCCAGACTCTCACAGTATGG
AGGCAAGCTGATAAACACAATATACCTCGAATCTGTTTTTTAAACAAGATGGACAAAACT
GGAGCAAGCTTTAAGTATGCAGTTGAAAGCATCAGAGAGAAGTTAAAGGCAAAGCCTTTG
CTTTTACAGTTACCAATTGGTGAAGCCAAAACTTTCAAAGGAGTGGTGGATGTAGTAATG
AAAGAAAAACTTCTTTGGAATTGCAATTCAAATGATGGAAAAGACTTTGAGAGAAAGCCC
CTCTTGGAAATGAATGATCCTGAATTGCTGAAGGAAACAACTGAAGCAAGGAATGCCTTA
ATTGAACAAGTTGCAGATTTGGATGATGAATTTGCTGACTTGGTTTTAGAAGAATTTAGT
GAGAATTTTGATTTGTTACCAGCTGAAAAGCTACAGACTGCAATACATAGAGTGACACTA
GCTCAGACAGCAGTGCCTGTGCTTTGTGGAAGTGCCCTGAAAAACAAAGGGATACAGCCC
TTGTTAGATGCTGTTACTATGTACTTACCTTCACCTGAAGAGCGTAACTATGAATTTCTG
CAGTGGTATAAGGATGACTTATGTGCATTGGCATTTAAAGTTCTCCATGACAAGCAGCGA
GGACCACTGGTTTTTATGCGCATTTACTCAGGCACTATAAAACCCCAGTTGGCCATTCAT
AATATTAATGGAAACTGCACGGAGAGAATAAGTCGTCTGCTTTTGCCGTTTGCTGACCAA
CATGTAGAAATCCCTTCATTGACTGCTGGTAACATTGCTTTGACTGTTGGGCTTAAACAT
ACTGCCACTGGAGACACCATTGTCTCATCCAAGTCCAGTGCATTAGCTGCAGCTCGTAGA
GCCGAACGGGAGGGAGAAAAGAAGCACAGACAAAACAATGAAGCAGAGAGACTTTTATTG
GCTGGAGTGGAGATTCCAGAACCTGTTTTCTTCTGTACCATAGAACCCCCATCACTGTCT
AAGCAGCCAGATTTGGAACATGCGTTGAAATGTCTTCAGCGTGAAGATCCCAGTTTGAAA
GTGAGGCTAGATCCTGACTCTGGACAAACTGTTCTGTGTGGTATGGGGGAGTTACATATA
GAGATTATTCATGATCGAATCAAGAGGGAATATGGACTGGAGACCTATCTCGGGCCTCTC
CAGGTGGCATATCGAGAGACCATCCTAAACTCAGTTCGTGCCACAGATACCTTAGATAGA
ACTTTAGGAGACAAAAGGCATCTTGTGACTGTAGAAGTGGAAGCAAGGCCAATTGAAACA
TCATCTGTTATGCCTGTGATTGAGTTTGAGTATGCTGAAAGTATCAATGAAGGCCTTTTG
AAGGTCTCCCAAGAGGCCATTGAAAATGGAATTCACAGCGCATGTCTCCAAGGACCATTG
CTTGGATCCCCAATTCAGGATGTAGCAATTACTTTACATTCCCTGACAATTCATCCTGGC
ACCTCCACAACTATGATTTCTGCCTGTGTCTCAAGATGCGTGCAAAAGGCTCTGAAGAAA
GCTGATAAGCAAGTTTTGGAGCCTCTGATGAATCTTGAGGTTACAGTAGCTAGAGATTAT
CTCAGCCCTGTCCTGGCAGATCTGGCACAAAGAAGAGGAAACATTCAGGAAATTCAGACT
CGCCAGGACAACAAAGTTGTTATTGGATTTGTTCCCTTAGCAGAAATTATGGGTTATTCA
ACTGTGCTTCGAACGCTAACATCAGGCTCAGCTACTTTTGCCTTAGAACTATCTACTTAT
CAAGCCATGAATCCTCAAGATCAAAATACACTGCTCAACCGGAGAAGTGGTTTGACCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 779 |
| Molecular Weight
| 86599.7 |
| Theoretical pI
| 6.47 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ribosome-releasing factor 2, mitochondrial
MLTNLRIFAMSHQTIPSVYINNICCYKIRASLKRLKPHVPLGRNCSSLPGLIGNDIKSLH
SIINPPIAKIRNIGIMAHIDAGKTTTTERILYYSGYTRSLGDVDDGDTVTDFMAQERERG
ITIQSAAVTFDWKGYRVNLIDTPGHVDFTLEVERCLRVLDGAVAVFDASAGVEAQTLTVW
RQADKHNIPRICFLNKMDKTGASFKYAVESIREKLKAKPLLLQLPIGEAKTFKGVVDVVM
KEKLLWNCNSNDGKDFERKPLLEMNDPELLKETTEARNALIEQVADLDDEFADLVLEEFS
ENFDLLPAEKLQTAIHRVTLAQTAVPVLCGSALKNKGIQPLLDAVTMYLPSPEERNYEFL
QWYKDDLCALAFKVLHDKQRGPLVFMRIYSGTIKPQLAIHNINGNCTERISRLLLPFADQ
HVEIPSLTAGNIALTVGLKHTATGDTIVSSKSSALAAARRAEREGEKKHRQNNEAERLLL
AGVEIPEPVFFCTIEPPSLSKQPDLEHALKCLQREDPSLKVRLDPDSGQTVLCGMGELHI
EIIHDRIKREYGLETYLGPLQVAYRETILNSVRATDTLDRTLGDKRHLVTVEVEARPIET
SSVMPVIEFEYAESINEGLLKVSQEAIENGIHSACLQGPLLGSPIQDVAITLHSLTIHPG
TSTTMISACVSRCVQKALKKADKQVLEPLMNLEVTVARDYLSPVLADLAQRRGNIQEIQT
RQDNKVVIGFVPLAEIMGYSTVLRTLTSGSATFALELSTYQAMNPQDQNTLLNRRSGLT
|
| External Links |
|---|
| GenBank ID Protein
| 19923640 |
| UniProtKB/Swiss-Prot ID
| Q969S9 |
| UniProtKB/Swiss-Prot Entry Name
| RRF2M_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_032380.3 |
| GeneCard ID
| GFM2 |
| GenAtlas ID
| GFM2 |
| HGNC ID
| HGNC:29682 |
| References |
|---|
| General References
| Not Available |