| Identification |
|---|
| HMDB Protein ID
| CDBP03574 |
| Secondary Accession Numbers
| Not Available |
| Name
| Dedicator of cytokinesis protein 9 |
| Description
| Not Available |
| Synonyms
|
- Cdc42 guanine nucleotide exchange factor zizimin-1
|
| Gene Name
| DOCK9 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in guanyl-nucleotide exchange factor activity |
| Specific Function
| Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation |
| GO Classification
|
| Function |
| purine nucleotide binding |
| binding |
| nucleotide binding |
| guanyl nucleotide binding |
| guanyl ribonucleotide binding |
| gtp binding |
| enzyme regulator activity |
| protein binding |
| gtpase binding |
| enzyme binding |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| guanyl-nucleotide exchange factor activity |
|
| Cellular Location
|
- Endomembrane system (Probable)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 13q32.3 |
| SNPs
| DOCK9 |
| Gene Sequence
|
>6210 bp
ATGTCGCAGCCGCCGCTGCTCCCCGCCTCGGCGGAGACTCGGAAGTTCACCCGGGCGCTG
AGTAAGCCGGGCACGGCGGCCGAGCTGCGGCAGAGCGTGTCTGAGGTGGTGCGCGGCTCC
GTGCTCCTGGCAAAGCCAAAGCTAATTGAGCCACTCGACTATGAAAATGTCATCGTCCAG
AAGAAGACTCAGATCCTGAACGACTGTTTACGGGAGATGCTGCTCTTCCCTTACGATGAC
TTTCAGACGGCCATCCTGAGACGACAGGGTCGATACATATGCTCAACAGTGCCTGCGAAG
GCGGAAGAGGAAGCACAGAGCTTGTTTGTTACAGAGTGCATCAAAACCTATAACTCTGAC
TGGCATCTTGTGAACTATAAATATGAAGATTACTCAGGAGAGTTTCGACAGCTTCCGAAC
AAAGTGGTCAAGTTGGATAAACTTCCAGTTCATGTCTATGAAGTTGACGAGGAGGTCGAC
AAAGATGAGGATGCTGCCTCCCTTGGTTCCCAGAAGGGTGGGATCACCAAGCATGGCTGG
CTGTACAAAGGCAACATGAACAGTGCCATCAGCGTGACCATGAGGTCATTTAAGAGACGA
TTTTTCCACCTGATTCAACTTGGCGATGGATCCTATAATTTGAATTTTTATAAAGATGAA
AAGATCTCCAAAGAACCAAAAGGATCAATATTTCTGGATTCCTGTATGGGTGTCGTTCAG
AACAACAAAGTCAGGCGTTTTGCTTTTGAGCTCAAGATGCAGGACAAAAGTAGTTATCTC
TTGGCAGCAGACAGTGAAGTGGAAATGGAAGAATGGATCACAATTCTAAATAAGATCCTC
CAGCTCAACTTTGAAGCTGCAATGCAAGAAAAGCGAAATGGCGACTCTCACGAAGATGAT
GAACAAAGCAAATTGGAAGGTTCTGGTTCCGGTTTAGATAGCTACCTGCCGGAACTTGCC
AAGAGTGCAAGAGAAGCAGAAATCAAACTGAAAAGTGAAAGCAGAGTCAAACTTTTTTAT
TTGGACCCAGATGCCCAGAAGCTTGACTTCTCATCAGCTGAGCCAGAAGTGAAGTCATTT
GAAGAGAAGTTTGGAAAAAGGATCCTTGTCAAGTGCAATGATTTATCTTTCAATTTGCAA
TGCTGTGTTGCCGAAAATGAAGAAGGACCCACTACAAATGTTGAACCTTTCTTTGTTACT
CTATCCCTGTTTGACATAAAATACAACCGGAAGATTTCTGCCGATTTCCACGTAGACCTG
AACCATTTCTCAGTGAGGCAAATGCTCGCCACCACGTCCCCGGCGCTGATGAATGGCAGT
GGGCAGAGCCCATCTGTCCTCAAGGGCATCCTTCATGAAGCCGCCATGCAGTATCCGAAG
CAGGGAATATTTTCAGTCACTTGTCCTCATCCAGATATATTTCTTGTGGCCAGAATTGAA
AAAGTCCTTCAGGGGAGCATCACACATTGCGCTGAGCCATATATGAAAAGTTCAGACTCT
TCTAAGGTGGCCCAGAAGGTGCTGAAGAATGCCAAGCAGGCATGCCAAAGACTAGGACAG
TATAGAATGCCATTTGCTTGGGCAGCAAGGACATTGTTTAAGGATGCATCTGGAAATCTT
GACAAAAATGCCAGATTTTCTGCCATCTACAGGCAAGACAGCAATAAGCTATCCAATGAT
GACATGCTCAAGTTACTTGCAGACTTTCGGAAACCTGAGAAGATGGCTAAGCTCCCAGTG
ATTTTAGGCAATCTAGACATTACAATTGATAATGTTTCCTCAGACTTCCCTAATTATGTT
AATTCATCATACATTCCCACAAAACAATTTGAAACCTGCAGTAAAACTCCCATCACGTTT
GAAGTGGAGGAATTTGTGCCCTGCATACCAAAACACACTCAGCCTTACACCATCTACACC
AATCACCTTTACGTTTATCCTAAGTACTTGAAATACGACAGTCAGAAGTCTTTTGCCAAG
GCTAGAAATATTGCGATTTGCATTGAATTCAAAGATTCAGATGAGGAAGACTCTCAGCCC
CTTAAGTGCATTTATGGCAGACCTGGTGGGCCAGTTTTCACAAGAAGCGCCTTTGCTGCA
GTTTTACACCATCACCAAAACCCAGAATTTTATGATGAGATTAAAATAGAGTTGCCCACT
CAGCTGCATGAAAAGCACCACCTGTTGCTCACATTCTTCCATGTCAGCTGTGACAACTCA
AGTAAAGGAAGCACGAAGAAGAGGGATGTCGTTGAAACCCAAGTTGGCTACTCCTGGCTT
CCCCTCCTGAAAGACGGAAGGGTGGTGACAAGCGAGCAGCACATCCCGGTCTCGGCGAAC
CTTCCTTCGGGCTATCTTGGCTACCAGGAGCTTGGGATGGGCAGGCATTATGGTCCGGAA
ATTAAATGGGTAGATGGAGGCAAGCCACTGCTGAAAATTTCCACTCATCTGGTTTCTACA
GTGTATACTCAGGATCAGCATTTACATAATTTTTTCCAGTACTGTCAGAAAACCGAATCT
GGAGCCCAAGCCTTAGGAAACGAACTTGTAAAGTACCTTAAGAGTCTGCATGCGATGGAA
GGCCACGTGATGATCGCCTTCTTGCCCACTATCCTAAACCAGCTGTTCCGAGTCCTCACC
AGAGCCACACAGGAAGAAGTCGCGGTTAACGTGACTCGGGTCATTATTCATGTGGTTGCC
CAGTGCCATGAGGAAGGATTGGAGAGCCACTTGAGGTCATATGTTAAGTACGCGTATAAG
GCTGAGCCATATGTTGCCTCTGAATACAAGACAGTGCATGAAGAACTGACCAAATCCATG
ACCACGATTCTCAAGCCTTCTGCCGATTTCCTCACCAGCAACAAACTACTGAAGTACTCA
TGGTTTTTCTTTGATGTACTGATCAAATCTATGGCTCAGCATTTGATAGAGAACTCCAAA
GTTAAGTTGCTGCGAAACCAGAGATTTCCTGCATCCTATCATCATGCAGTGGAAACCGTT
GTAAATATGCTGATGCCACACATCACTCAGAAGTTTCGAGATAATCCAGAGGCATCTAAG
AACGCGAATCATAGCCTTGCTGTCTTCATCAAGAGATGTTTCACCTTCATGGACAGGGGC
TTTGTCTTCAAGCAGATCAACAACTACATTAGCTGTTTTGCTCCTGGAGACCCAAAGACC
CTCTTTGAATACAAGTTTGAATTTCTCCGTGTAGTGTGCAACCATGAACATTATATTCCG
TTGAACTTACCAATGCCATTTGGAAAAGGCAGGATTCAAAGATACCAAGACCTCCAGCTT
GACTACTCATTAACAGATGAGTTCTGCAGAAACCACTTCTTGGTGGGACTGTTACTGAGG
GAGGTGGGGACAGCCCTCCAGGAGTTCCGGGAGGTCCGTCTGATCGCCATCAGTGTGCTC
AAGAACCTGCTGATAAAGCATTCTTTTGATGACAGATATGCTTCAAGGAGCCATCAGGCA
AGGATAGCCACCCTCTACCTGCCTCTGTTTGGTCTGCTGATTGAAAACGTCCAGCGGATC
AATGTGAGGGATGTGTCACCCTTCCCTGTGAACGCGGGCATGACTGTGAAGGATGAATCC
CTGGCTCTACCAGCTGTGAATCCGCTGGTGACGCCGCAGAAGGGAAGCACCCTGGACAAC
AGCCTGCACAAGGACCTGCTGGGCGCCATCTCCGGCATTGCTTCTCCATATACAACCTCA
ACTCCAAACATCAACAGTGTGAGAAATGCTGATTCGAGAGGATCTCTCATAAGCACAGAT
TCGGGTAACAGCCTTCCAGAAAGGAATAGTGAGAAGAGCAATTCCCTGGATAAGCACCAA
CAAAGTAGCACATTGGGAAATTCCGTGGTTCGCTGTGATAAACTTGACCAGTCTGAGATT
AAGAGCCTACTGATGTGTTTCCTCTACATCTTAAAGAGCATGTCTGATGATGCTTTGTTT
ACATATTGGAACAAGGCTTCAACATCTGAACTTATGGATTTTTTTACAATATCTGAAGTC
TGCCTGCACCAGTTCCAGTACATGGGGAAGCGATACATAGCCAGAACAGGAATGATGCAT
GCCAGATTGCAGCAGCTGGGCAGCCTGGATAACTCTCTCACTTTTAACCACAGCTATGGC
CACTCGGACGCAGATGTTCTGCACCAGTCATTACTTGAAGCCAACATTGCTACTGAGGTT
TGCCTGACAGCTCTGGACACGCTTTCTCTATTTACATTGGCGTTTAAGAACCAGCTCCTG
GCCGACCATGGACATAATCCTCTCATGAAAAAAGTTTTTGATGTCTACCTGTGTTTTCTT
CAAAAACATCAGTCTGAAACGGCTTTAAAAAATGTCTTCACTGCCTTAAGGTCCTTAATT
TATAAGTTTCCCTCAACATTCTATGAAGGGAGAGCGGACATGTGTGCGGCTCTGTGTTAC
GAGATTCTCAAGTGCTGTAACTCCAAGCTGAGCTCCATCAGGACGGAGGCCTCCCAGCTG
CTCTACTTCCTGATGAGGAACAACTTTGATTACACTGGAAAGAAGTCCTTTGTCCGGACA
CATTTGCAAGTCATCATATCTGTCAGCCAGCTGATAGCAGACGTTGTTGGCATTGGGGGA
ACCAGATTCCAGCAGTCCCTGTCCATCATCAACAACTGTGCCAACAGTGACCGGCTTATT
AAGCACACCAGCTTCTCCTCTGATGTGAAGGACTTAACCAAAAGGATACGCACGGTGCTA
ATGGCCACCGCCCAGATGAAGGAGCATGAGAACGACCCAGAGATGCTGGTGGACCTCCAG
TACAGCCTGGCCAAATCCTATGCCAGCACGCCCGAGCTCAGGAAGACGTGGCTCGACAGC
ATGGCCAGGATCCATGTCAAAAATGGCGATCTCTCAGAGGCAGCAATGTGCTATGTCCAC
GTAACAGCCCTAGTGGCAGAATATCTCACACGGAAAGAAGCAGTCCAGTGGGAGCCGCCC
CTTCTCCCCCACAGCCATAGCGCCTGCCTGAGGAGGAGCCGGGGAGGCGTGTTTAGACAA
GGATGCACCGCCTTCAGGGTCATTACCCCAAACATCGACGAGGAGGCCTCCATGATGGAA
GACGTGGGGATGCAGGATGTCCATTTCAACGAGGATGTGCTGATGGAGCTCCTTGAGCAG
TGCGCAGATGGACTCTGGAAAGCCGAGCGCTACGAGCTCATCGCCGACATCTACAAACTT
ATCATCCCCATTTATGAGAAGCGGAGGGATTTTGAGAGGCTGGCCCATCTGTATGACACG
CTGCACCGGGCCTACAGCAAAGTGACCGAGGTCATGCACTCGGGCCGCAGGCTTCTGGGG
ACCTACTTCCGGGTAGCCTTCTTCGGGCAGGCAGCGCAATACCAGTTTACAGACAGTGAA
ACAGATGTGGAGGGATTCTTTGAAGATGAAGATGGAAAGGAGTATATTTACAAGGAACCC
AAACTCACACCGCTGTCGGAAATTTCTCAGAGACTCCTTAAACTGTACTCGGATAAATTT
GGTTCTGAAAATGTCAAAATGATACAGGATTCTGGCAAGGTCAACCCTAAGGATCTGGAT
TCTAAGTATGCATACATCCAGGTGACTCACGTCATCCCCTTCTTTGACGAAAAAGAGTTG
CAAGAAAGGAAAACAGAGTTTGAGAGATCCCACAACATCCGCCGCTTCATGTTTGAGATG
CCATTTACGCAGACCGGGAAGAGGCAGGGCGGGGTGGAAGAGCAGTGCAAACGGCGCACC
ATCCTGACAGCCATACACTGCTTCCCTTATGTGAAGAAGCGCATCCCTGTCATGTACCAG
CACCACACTGACCTGAACCCCATCGAGGTGGCCATTGACGAGATGAGTAAGAAGGTGGCG
GAGCTCCGGCAGCTGTGCTCCTCGGCCGAGGTGGACATGATCAAACTGCAGCTCAAACTC
CAGGGCAGCGTGAGTGTTCAGGTCAATGCTGGCCCACTAGCATATGCGCGAGCTTTCTTA
GATGATACAAACACAAAGCGATATCCTGACAATAAAGTGAAGCTGCTTAAGGAAGTTTTC
AGGCAATTTGTGGAAGCTTGCGGTCAAGCCTTAGCGGTAAACGAACGTCTGATTAAAGAA
GACCAGCTCGAGTATCAGGAAGAAATGAAAGCCAACTACAGGGAAATGGCGAAGGAGCTT
TCTGAAATCATGCATGAGCAGCTGGGATGA
|
| Protein Properties |
|---|
| Number of Residues
| 2069 |
| Molecular Weight
| 236443.6 |
| Theoretical pI
| 7.51 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Dedicator of cytokinesis protein 9
MSQPPLLPASAETRKFTRALSKPGTAAELRQSVSEVVRGSVLLAKPKLIEPLDYENVIVQ
KKTQILNDCLREMLLFPYDDFQTAILRRQGRYICSTVPAKAEEEAQSLFVTECIKTYNSD
WHLVNYKYEDYSGEFRQLPNKVVKLDKLPVHVYEVDEEVDKDEDAASLGSQKGGITKHGW
LYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMGVVQ
NNKVRRFAFELKMQDKSSYLLAADSEVEMEEWITILNKILQLNFEAAMQEKRNGDSHEDD
EQSKLEGSGSGLDSYLPELAKSAREAEIKLKSESRVKLFYLDPDAQKLDFSSAEPEVKSF
EEKFGKRILVKCNDLSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDL
NHFSVRQMLATTSPALMNGSGQSPSVLKGILHEAAMQYPKQGIFSVTCPHPDIFLVARIE
KVLQGSITHCAEPYMKSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAARTLFKDASGNL
DKNARFSAIYRQDSNKLSNDDMLKLLADFRKPEKMAKLPVILGNLDITIDNVSSDFPNYV
NSSYIPTKQFETCSKTPITFEVEEFVPCIPKHTQPYTIYTNHLYVYPKYLKYDSQKSFAK
ARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSAFAAVLHHHQNPEFYDEIKIELPT
QLHEKHHLLLTFFHVSCDNSSKGSTKKRDVVETQVGYSWLPLLKDGRVVTSEQHIPVSAN
LPSGYLGYQELGMGRHYGPEIKWVDGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTES
GAQALGNELVKYLKSLHAMEGHVMIAFLPTILNQLFRVLTRATQEEVAVNVTRVIIHVVA
QCHEEGLESHLRSYVKYAYKAEPYVASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYS
WFFFDVLIKSMAQHLIENSKVKLLRNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASK
NANHSLAVFIKRCFTFMDRGFVFKQINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIP
LNLPMPFGKGRIQRYQDLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRLIAISVL
KNLLIKHSFDDRYASRSHQARIATLYLPLFGLLIENVQRINVRDVSPFPVNAGMTVKDES
LALPAVNPLVTPQKGSTLDNSLHKDLLGAISGIASPYTTSTPNINSVRNADSRGSLISTD
SGNSLPERNSEKSNSLDKHQQSSTLGNSVVRCDKLDQSEIKSLLMCFLYILKSMSDDALF
TYWNKASTSELMDFFTISEVCLHQFQYMGKRYIARTGMMHARLQQLGSLDNSLTFNHSYG
HSDADVLHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLCFL
QKHQSETALKNVFTALRSLIYKFPSTFYEGRADMCAALCYEILKCCNSKLSSIRTEASQL
LYFLMRNNFDYTGKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANSDRLI
KHTSFSSDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDS
MARIHVKNGDLSEAAMCYVHVTALVAEYLTRKEAVQWEPPLLPHSHSACLRRSRGGVFRQ
GCTAFRVITPNIDEEASMMEDVGMQDVHFNEDVLMELLEQCADGLWKAERYELIADIYKL
IIPIYEKRRDFERLAHLYDTLHRAYSKVTEVMHSGRRLLGTYFRVAFFGQAAQYQFTDSE
TDVEGFFEDEDGKEYIYKEPKLTPLSEISQRLLKLYSDKFGSENVKMIQDSGKVNPKDLD
SKYAYIQVTHVIPFFDEKELQERKTEFERSHNIRRFMFEMPFTQTGKRQGGVEEQCKRRT
ILTAIHCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLCSSAEVDMIKLQLKL
QGSVSVQVNAGPLAYARAFLDDTNTKRYPDNKVKLLKEVFRQFVEACGQALAVNERLIKE
DQLEYQEEMKANYREMAKELSEIMHEQLG
|
| External Links |
|---|
| GenBank ID Protein
| 24308029 |
| UniProtKB/Swiss-Prot ID
| Q9BZ29 |
| UniProtKB/Swiss-Prot Entry Name
| DOCK9_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_015296.2 |
| GeneCard ID
| DOCK9 |
| GenAtlas ID
| DOCK9 |
| HGNC ID
| HGNC:14132 |
| References |
|---|
| General References
| Not Available |