| Identification |
|---|
| HMDB Protein ID
| CDBP03565 |
| Secondary Accession Numbers
| Not Available |
| Name
| Dedicator of cytokinesis protein 11 |
| Description
| Not Available |
| Synonyms
|
- ACG
- Activated Cdc42-associated guanine nucleotide exchange factor
- Zizimin-2
|
| Gene Name
| DOCK11 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in guanyl-nucleotide exchange factor activity |
| Specific Function
| Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP |
| GO Classification
|
| Function |
| purine nucleotide binding |
| binding |
| nucleotide binding |
| guanyl nucleotide binding |
| guanyl ribonucleotide binding |
| gtp binding |
| enzyme regulator activity |
| protein binding |
| gtpase binding |
| enzyme binding |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| guanyl-nucleotide exchange factor activity |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| DOCK11 |
| Gene Sequence
|
>6222 bp
ATGGCCGAAGTGCGCAAATTCACCAAACGGCTCAGCAAGCCTGGCACGGCGGCTGAGCTC
CGGCAGAGCGTGTCTGAGGCCGTGCGGGGCTCCGTGGTGCTGGAAAAGGCCAAAGTTGTT
GAGCCCCTGGACTATGAGAATGTTATTGCCCAAAGAAAAACCCAGATTTACAGCGACCCC
CTCCGAGATCTGCTTATGTTCCCAATGGAAGATATATCTATCTCGGTGATAGGTCGTCAA
CGCAGAACGGTGCAGTCTACTGTACCAGAAGATGCTGAAAAGAGGGCCCAGAGTTTATTT
GTTAAAGAGTGTATTAAAACCTATAGCACAGATTGGCACGTGGTAAACTACAAGTATGAG
GACTTCTCTGGGGACTTTCGAATGTTGCCATGTAAATCTTTGAGACCAGAAAAGATTCCT
AATCATGTATTTGAGATAGATGAAGACTGTGAGAAAGATGAGGACTCATCTTCTTTATGT
TCTCAGAAGGGTGGTGTGATAAAACAAGGCTGGTTGCATAAAGCAAATGTAAATAGTACC
ATCACAGTAACCATGAAGGTATTCAAGAGACGATATTTTTACTTGACCCAACTTCCTGAC
GGTTCATATATTCTCAATTCCTATAAAGATGAGAAAAATTCAAAAGAATCGAAAGGTTGC
ATCTACTTGGACGCCTGCATTGATGTTGTTCAGTGCCCCAAAATGCGCCGTCATGCTTTT
GAACTCAAGATGTTAGATAAATATAGCCATTATCTGGCTGCTGAAACTGAGCAGGAAATG
GAGGAATGGTTGATAACTTTGAAAAAGATTATTCAGATCAACACCGACAGTTTAGTTCAA
GAAAAAAAGGAGACGGTAGAAACAGCACAAGATGATGAAACTAGCAGCCAAGGAAAAGCC
GAGAACATCATGGCAAGTTTGGAAAGGAGCATGCATCCGGAACTGATGAAGTATGGAAGA
GAAACTGAACAACTAAACAAACTCAGTAGAGGAGATGGAAGACAGAATCTCTTTTCTTTT
GATTCAGAAGTTCAGAGGTTGGACTTTTCAGGAATTGAACCTGATATAAAGCCATTTGAA
GAAAAATGCAATAAACGTTTCCTGGTGAATTGCCATGATTTAACTTTCAATATCTTGGGC
CAAATTGGAGACAATGCAAAAGGACCACCCACAAATGTTGAGCCCTTTTTTATCAATCTT
GCCTTATTTGATGTAAAGAACAATTGTAAGATTTCAGCAGACTTTCATGTAGACCTGAAT
CCCCCATCTGTCCGTGAAATGCTGTGGGGCTCTTCAACCCAACTGGCCAGTGACGGTAGC
CCAAAGGGCTCTTCACCCGAATCTTACATTCATGGAATTGCCGAATCTCAGTTACGCTAC
ATACAACAGGGAATTTTCTCAGTGACGAATCCACATCCTGAAATTTTTCTAGTTGCCAGA
ATTGAAAAGGTACTACAGGGAAACATTACACACTGTGCAGAACCCTATATCAAAAATTCT
GATCCAGTAAAGACGGCCCAGAAGGTGCACAGGACAGCTAAACAAGTGTGTAGCCGCCTT
GGACAATACAGAATGCCCTTCGCTTGGGCTGCCAGACCCATTTTCAAAGATACTCAAGGC
TCTCTTGATCTGGATGGGAGATTTTCTCCTCTGTATAAACAAGACAGTAGCAAGCTTTCA
AGTGAAGACATTCTCAAGTTGCTCTCAGAATATAAGAAGCCAGAAAAGACCAAACTGCAG
ATTATTCCTGGGCAGCTAAACATCACAGTAGAATGTGTTCCTGTGGATTTATCAAATTGT
ATTACTTCTTCATATGTGCCCTTGAAGCCTTTTGAAAAGAATTGCCAAAATATTACTGTG
GAGGTTGAAGAGTTTGTTCCAGAAATGACAAAATATTGTTATCCATTTACTATTTACAAA
AACCATCTGTATGTATATCCCCTGCAATTAAAATACGATAGCCAGAAAACATTTGCCAAG
GCAAGGAACATTGCAGTCTGTGTGGAATTCCGGGATTCAGATGAAAGTGACGCTAGTGCC
CTAAAGTGTATTTATGGAAAACCTGCAGGGTCTGTTTTTACCACAAATGCTTATGCTGTT
GTCTCGCATCACAACCAAAATCCAGAGTTCTATGATGAGATTAAAATTGAGCTTCCCATT
CACCTACATCAAAAACATCATTTGCTTTTCACTTTTTATCATGTAAGTTGTGAAATTAAC
ACAAAGGGAACAACCAAAAAGCAAGACACAGTTGAAACTCCAGTTGGGTTTGCCTGGGTA
CCTTTGCTGAAAGATGGTAGAATCATCACATTTGAGCAGCAGCTGCCAGTTTCCGCCAAT
CTTCCCCCAGGCTACTTGAATCTGAATGATGCAGAATCAAGAAGGCAATGTAACGTGGAT
ATTAAATGGGTAGATGGTGCAAAGCCTTTGTTGAAGATTAAAAGCCACTTAGAATCTACC
ATTTACACTCAAGATCTGCATGTGCACAAATTCTTCCATCATTGCCAGCTGATTCAGTCA
GGCTCGAAAGAAGTTCCAGGGGAGCTCATTAAATATTTAAAGTGTTTGCATGCCATGGAG
ATCCAAGTCATGATACAGTTTCTACCTGTAATTCTTATGCAACTCTTCCGAGTTCTCACA
AATATGACCCATGAAGATGACGTTCCTATCAACTGCACCATGGTTCTCTTACATATTGTA
TCAAAGTGCCATGAAGAAGGCTTGGATAGTTATCTAAGATCATTCATAAAGTATAGCTTC
CGACCTGAAAAACCGAGTGCTCCTCAGGCCCAGCTGATACATGAAACCCTGGCTACTACG
ATGATAGCAATATTGAAACAGTCTGCAGATTTTTTATCAATAAACAAATTGCTAAAGTAC
TCATGGTTTTTCTTTGAAATAATTGCAAAGTCAATGGCCACATACTTGTTGGAAGAGAAT
AAGATTAAGCTTCCCCGAGGCCAGAGATTTCCCGAGACATATCATCATGTCTTACATTCA
CTGCTTCTTGCAATAATTCCCCATGTGACTATTCGGTATGCGGAGATTCCCGATGAGTCC
AGAAATGTGAACTATAGTTTGGCTAGCTTCCTGAAGCGCTGTTTGACACTAATGGATAGA
GGATTTATTTTCAATTTAATAAATGACTATATATCTGGATTCAGCCCCAAAGATCCTAAG
GTTCTGGCTGAATACAAGTTTGAATTTCTGCAAACAATTTGCAATCACGAACATTACATT
CCTCTGAACTTGCCAATGGCATTTGCAAAACCTAAACTGCAGCGGGTTCAAGATTCAAAT
CTTGAATACAGTTTATCAGATGAGTATTGCAAGCATCACTTCTTGGTTGGTCTACTTCTG
AGGGAAACTTCCATTGCTCTTCAGGACAATTATGAGATCAGATATACAGCTATCTCTGTT
ATAAAGAATCTTTTGATAAAACATGCATTTGACACAAGATACCAGCACAAGAACCAACAA
GCCAAAATAGCACAATTGTACCTCCCCTTTGTTGGACTACTTTTGGAAAATATACAGCGA
TTAGCAGGTCGAGATACCTTGTATTCTTGTGCAGCCATGCCTAATTCTGCATCCAGAGAT
GAGTTTCCATGTGGCTTTACTTCACCTGCCAATAGAGGGAGTCTGAGCACTGACAAAGAC
ACCGCTTATGGGTCTTTTCAAAATGGACATGGAATTAAGAGAGAAGATTCAAGAGGTTCC
CTCATCCCAGAAGGAGCAACAGGATTTCCAGATCAGGGCAACACTGGTGAAAATACCCGA
CAGAGTTCTACAAGGAGTAGTGTATCCCAGTATAACCGCCTGGATCAGTATGAAATCAGA
AGCCTCCTGATGTGCTACCTGTATATAGTAAAAATGATTTCAGAAGATACTCTCTTAACT
TACTGGAATAAAGTATCACCTCAGGAGCTCATAAACATTCTTATACTTTTAGAAGTATGC
TTGTTTCACTTTAGATATATGGGGAAAAGAAACATAGCAAGGGTGCATGATGCCTGGCTG
TCAAAACACTTCGGAATAGACCGAAAATCGCAAACCATGCCTGCTCTTCGAAACAGATCA
GGAGTAATGCAGGCCCGGCTTCAGCATCTTAGTAGCCTAGAAAGTTCATTTACACTTAAT
CACAGTTCTACAACAACTGAAGCAGACATTTTCCACCAGGCACTTCTTGAAGGCAATACA
GCTACTGAAGTTTCCCTAACAGTACTAGACACCATATCATTTTTCACTCAGTGCTTCAAG
ACCCAACTTTTAAATAATGATGGCCATAACCCATTAATGAAAAAAGTGTTTGATATACAT
CTTGCTTTTCTTAAAAATGGACAATCTGAAGTGTCGCTGAAACATGTATTTGCCTCACTG
AGAGCTTTCATCAGTAAGTTTCCTTCAGCATTTTTCAAAGGAAGAGTAAACATGTGTGCT
GCATTTTGCTATGAGGTTTTAAAGTGCTGCACATCGAAGATTAGCTCAACCAGGAATGAA
GCATCTGCACTTTTGTATCTTTTGATGAGAAACAACTTTGAGTATACCAAAAGGAAAACC
TTTTTGAGGACACATCTACAGATAATAATTGCTGTAAGCCAACTGATAGCTGATGTAGCA
CTAAGCGGAGGATCAAGATTTCAGGAGTCTTTATTCATTATCAATAATTTTGCAAATAGT
GACAGACCTATGAAGGCAACTGCCTTTCCCGCAGAAGTCAAAGACTTGACCAAGAGAATC
CGCACTGTTCTTATGGCCACTGCCCAAATGAAGGAGCATGAGAAAGACCCTGAAATGCTA
ATTGATCTCCAGTATAGCTTAGCCAAGTCCTATGCAAGCACCCCAGAGCTCAGGAAAACC
TGGCTTGATAGCATGGCCAAGATTCATGTAAAAAATGGAGATTTTTCAGAGGCTGCGATG
TGTTATGTCCATGTAGCAGCTCTAGTTGCAGAGTTTCTTCATCGAAAAAAATTATTTCCT
AACGGATGTTCAGCGTTCAAGAAAATTACTCCCAATATAGATGAAGAAGGAGCAATGAAA
GAAGATGCTGGGATGATGGATGTCCATTATAGTGAAGAGGTCTTGCTGGAGTTGCTAGAA
CAATGTGTGGATGGCTTATGGAAGGCAGAACGTTATGAAATAATTTCTGAGATTTCCAAG
TTGATCGTTCCAATTTATGAGAAACGTCGTGAGTTTGAGAAACTTACTCAAGTTTATAGA
ACTCTTCATGGAGCTTACACAAAAATTCTGGAAGTTATGCATACAAAAAAGAGACTTTTA
GGCACTTTCTTCAGAGTTGCCTTTTATGGCCAATCTTTTTTTGAAGAAGAAGATGGAAAG
GAGTACATCTATAAAGAACCAAAGCTCACTGGCCTCTCAGAAATTTCCTTGAGACTTGTT
AAACTTTATGGTGAAAAGTTTGGTACGGAGAATGTCAAAATAATTCAGGATTCAGACAAG
GTAAATGCCAAAGAGCTTGATCCAAAATATGCTCATATACAAGTTACTTATGTGAAGCCT
TACTTTGATGACAAAGAACTCACAGAAAGGAAGACCGAGTTTGAAAGAAATCATAATATC
AGCAGATTTGTTTTTGAGGCCCCTTACACTTTATCAGGCAAAAAACAGGGCTGTATAGAA
GAACAGTGCAAACGCCGTACAATCTTGACAACTTCAAACTCGTTTCCTTACGTGAAGAAG
AGGATTCCTATTAACTGTGAACAGCAGATTAATTTAAAACCAATTGATGTTGCCACTGAT
GAAATAAAAGATAAAACTGCAGAGCTGCAAAAGCTTTGCTCCTCTACTGACGTGGACATG
ATTCAGCTCCAACTTAAATTGCAGGGCTGTGTTTCTGTGCAGGTCAATGCTGGTCCATTA
GCATATGCAAGAGCTTTCTTAAATGACAGCCAAGCTAGCAAGTATCCACCTAAGAAAGTG
AGTGAGTTGAAAGACATGTTTAGGAAATTTATACAAGCATGCAGCATTGCACTTGAACTA
AATGAGCGGCTAATTAAAGAAGATCAAGTTGAGTACCATGAAGGGCTAAAGTCAAATTTC
AGAGACATGGTAAAAGAATTATCTGACATTATCCATGAGCAGATATTACAAGAAGACACA
ATGCATTCTCCCTGGATGAGCAACACATTACATGTATTTTGTGCAATTAGTGGTACATCA
AGTGACCGAGGTTATGGTTCCCCAAGATACGCTGAAGTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 2073 |
| Molecular Weight
| 237668.7 |
| Theoretical pI
| 7.79 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Dedicator of cytokinesis protein 11
MAEVRKFTKRLSKPGTAAELRQSVSEAVRGSVVLEKAKVVEPLDYENVIAQRKTQIYSDP
LRDLLMFPMEDISISVIGRQRRTVQSTVPEDAEKRAQSLFVKECIKTYSTDWHVVNYKYE
DFSGDFRMLPCKSLRPEKIPNHVFEIDEDCEKDEDSSSLCSQKGGVIKQGWLHKANVNST
ITVTMKVFKRRYFYLTQLPDGSYILNSYKDEKNSKESKGCIYLDACIDVVQCPKMRRHAF
ELKMLDKYSHYLAAETEQEMEEWLITLKKIIQINTDSLVQEKKETVETAQDDETSSQGKA
ENIMASLERSMHPELMKYGRETEQLNKLSRGDGRQNLFSFDSEVQRLDFSGIEPDIKPFE
EKCNKRFLVNCHDLTFNILGQIGDNAKGPPTNVEPFFINLALFDVKNNCKISADFHVDLN
PPSVREMLWGSSTQLASDGSPKGSSPESYIHGIAESQLRYIQQGIFSVTNPHPEIFLVAR
IEKVLQGNITHCAEPYIKNSDPVKTAQKVHRTAKQVCSRLGQYRMPFAWAARPIFKDTQG
SLDLDGRFSPLYKQDSSKLSSEDILKLLSEYKKPEKTKLQIIPGQLNITVECVPVDLSNC
ITSSYVPLKPFEKNCQNITVEVEEFVPEMTKYCYPFTIYKNHLYVYPLQLKYDSQKTFAK
ARNIAVCVEFRDSDESDASALKCIYGKPAGSVFTTNAYAVVSHHNQNPEFYDEIKIELPI
HLHQKHHLLFTFYHVSCEINTKGTTKKQDTVETPVGFAWVPLLKDGRIITFEQQLPVSAN
LPPGYLNLNDAESRRQCNVDIKWVDGAKPLLKIKSHLESTIYTQDLHVHKFFHHCQLIQS
GSKEVPGELIKYLKCLHAMEIQVMIQFLPVILMQLFRVLTNMTHEDDVPINCTMVLLHIV
SKCHEEGLDSYLRSFIKYSFRPEKPSAPQAQLIHETLATTMIAILKQSADFLSINKLLKY
SWFFFEIIAKSMATYLLEENKIKLPRGQRFPETYHHVLHSLLLAIIPHVTIRYAEIPDES
RNVNYSLASFLKRCLTLMDRGFIFNLINDYISGFSPKDPKVLAEYKFEFLQTICNHEHYI
PLNLPMAFAKPKLQRVQDSNLEYSLSDEYCKHHFLVGLLLRETSIALQDNYEIRYTAISV
IKNLLIKHAFDTRYQHKNQQAKIAQLYLPFVGLLLENIQRLAGRDTLYSCAAMPNSASRD
EFPCGFTSPANRGSLSTDKDTAYGSFQNGHGIKREDSRGSLIPEGATGFPDQGNTGENTR
QSSTRSSVSQYNRLDQYEIRSLLMCYLYIVKMISEDTLLTYWNKVSPQELINILILLEVC
LFHFRYMGKRNIARVHDAWLSKHFGIDRKSQTMPALRNRSGVMQARLQHLSSLESSFTLN
HSSTTTEADIFHQALLEGNTATEVSLTVLDTISFFTQCFKTQLLNNDGHNPLMKKVFDIH
LAFLKNGQSEVSLKHVFASLRAFISKFPSAFFKGRVNMCAAFCYEVLKCCTSKISSTRNE
ASALLYLLMRNNFEYTKRKTFLRTHLQIIIAVSQLIADVALSGGSRFQESLFIINNFANS
DRPMKATAFPAEVKDLTKRIRTVLMATAQMKEHEKDPEMLIDLQYSLAKSYASTPELRKT
WLDSMAKIHVKNGDFSEAAMCYVHVAALVAEFLHRKKLFPNGCSAFKKITPNIDEEGAMK
EDAGMMDVHYSEEVLLELLEQCVDGLWKAERYEIISEISKLIVPIYEKRREFEKLTQVYR
TLHGAYTKILEVMHTKKRLLGTFFRVAFYGQSFFEEEDGKEYIYKEPKLTGLSEISLRLV
KLYGEKFGTENVKIIQDSDKVNAKELDPKYAHIQVTYVKPYFDDKELTERKTEFERNHNI
SRFVFEAPYTLSGKKQGCIEEQCKRRTILTTSNSFPYVKKRIPINCEQQINLKPIDVATD
EIKDKTAELQKLCSSTDVDMIQLQLKLQGCVSVQVNAGPLAYARAFLNDSQASKYPPKKV
SELKDMFRKFIQACSIALELNERLIKEDQVEYHEGLKSNFRDMVKELSDIIHEQILQEDT
MHSPWMSNTLHVFCAISGTSSDRGYGSPRYAEV
|
| External Links |
|---|
| GenBank ID Protein
| 145699123 |
| UniProtKB/Swiss-Prot ID
| Q5JSL3 |
| UniProtKB/Swiss-Prot Entry Name
| DOC11_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_144658.3 |
| GeneCard ID
| DOCK11 |
| GenAtlas ID
| DOCK11 |
| HGNC ID
| HGNC:23483 |
| References |
|---|
| General References
| Not Available |