| Identification |
|---|
| HMDB Protein ID
| CDBP03560 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein diaphanous homolog 3 |
| Description
| Not Available |
| Synonyms
|
- DRF3
- Diaphanous-related formin-3
|
| Gene Name
| DIAPH3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in actin binding |
| Specific Function
| Binds to GTP-bound form of Rho and to profilin. Acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. It is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics |
| GO Classification
|
| Function |
| binding |
| protein binding |
| cytoskeletal protein binding |
| actin binding |
| gtpase binding |
| small gtpase binding |
| ras gtpase binding |
| rho gtpase binding |
| enzyme binding |
| Process |
| cellular process |
| cellular component organization at cellular level |
| organelle organization |
| cellular component organization or biogenesis |
| cellular component organization |
| cytoskeleton organization |
| actin cytoskeleton organization |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 13q21.2 |
| SNPs
| DIAPH3 |
| Gene Sequence
|
>3582 bp
ATGGAACGGCACCAGCCGCGGCTGCACCACCCGGCCCAAGGCTCAGCCGCTGGGACTCCC
TACCCTTCCTCAGCCTCTCTCCGCGGCTGCCGGGAAAGCAAGATGCCGCGCAGGAAGGGC
CCCCAACACCCTCCGCCGCCCAGTGGCCCCGAGGAGCCTGGGGAGAAGCGCCCCAAGTTT
CATTTAAATATTAGGACACTGACGGATGATATGCTGGACAAATTTGCCAGCATAAGAATT
CCAGGGAGCAAGAAAGAGAGACCTCCACTTCCCAACCTGAAGACTGCATTTGCAAGCAGT
GATTGCTCAGCAGCACCTTTAGAGATGATGGAGAACTTTCCAAAGCCACTGTCAGAGAAT
GAACTCTTAGAACTTTTTGAAAAAATGATGGAAGATATGAATTTAAATGAAGATAAAAAG
GCACCATTGCGGGAAAAGGACTTCAGTATCAAAAAAGAAATGGTGATGCAGTACATTAAT
ACTGCTTCTAAGACAGGAAGTCTTAAGAGAAGCCGACAGATCTCACCTCAGGAATTCATT
CATGAGCTGAAAATGGGGTCTGCAGATGAGAGACTTGTCACATGCCTGGAGTCTCTCCGA
GTGTCTTTGACCAGCAATCCTGTGAGTTGGGTGGAAAGCTTTGGACATGAAGGGCTTGGA
TTATTATTAGACATTTTGGAAAAACTGATTAGTGGAAAAATCCAAGAAAAAGTTGTAAAG
AAAAATCAACATAAAGTCATACAGTGTCTAAAAGCCCTGATGAATACGCAGTATGGCTTG
GAAAGAATTATGAGTGAGGAGAGGAGCCTTTCCTTATTGGCCAAAGCCGTGGATCCCAGA
CACCCCAATATGATGACAGATGTGGTTAAACTTCTCTCTGCGGTATGCATTGTAGGGGAA
GAAAGCATCCTTGAAGAAGTTTTAGAAGCTTTAACTTCAGCTGGTGAAGAAAAAAAAATT
GACAGATTTTTTTGTATTGTGGAAGGCCTCCGGCACAATTCAGTTCAACTGCAAGTAGCT
TGTATGCAGCTCATCAATGCCCTGGTTACATCTCCTGATGATTTGGATTTCAGGCTTCAC
ATCAGAAATGAATTTATGCGTTGTGGATTGAAAGAGATATTGCCAAATTTAAAATGCATT
AAGAATGATGGCCTGGATATCCAACTTAAAGTCTTTGATGAGCATAAAGAAGAAGATTTG
TTTGAGTTATCCCATCGCCTTGAAGATATTAGAGCTGAACTTGATGAAGCATATGATGTT
TACAACATGGTGTGGAGCACAGTTAAAGAAACTAGAGCAGAGGGATATTTTATTTCTATT
CTTCAGCATCTTTTGCTGATTCGAAATGATTATTTTATAAGGCAACAATACTTCAAATTA
ATTGATGAGTGTGTATCCCAGATTGTATTGCATAGAGATGGAATGGATCCAGACTTCACA
TATCGAAAAAGACTAGATTTAGATTTAACCCAGTTTGTAGACATTTGCATAGATCAAGCA
AAACTAGAAGAGTTTGAAGAGAAAGCATCAGAACTTTACAAGAAATTTGAAAAAGAGTTT
ACCGACCACCAAGAAACTCAGGCTGAATTGCAGAAAAAAGAGGCAAAGATTAATGAGCTT
CAAGCAGAGCTACAAGCTTTTAAGTCTCAGTTTGGTGCCTTGCCAGCTGATTGTAATATT
CCTTTGCCTCCCTCTAAAGAAGGTGGAACTGGCCACTCAGCACTTCCTCCTCCGCCTCCA
CTGCCTTCTGGTGGAGGGGTGCCGCCTCCACCTCCTCCCCCACCACCTCCTCCACTTCCA
GGAATGCGGATGCCATTCAGTGGTCCTGTGCCTCCACCACCTCCCCTGGGATTCCTTGGA
GGACAAAATTCTCCTCCTCTACCAATCCTGCCATTTGGGTTGAAACCAAAGAAAGAATTT
AAACCTGAAATCAGCATGAGAAGATTGAATTGGTTAAAGATCAGACCTCATGAAATGACT
GAAAACTGTTTCTGGATAAAAGTAAATGAAAATAAGTATGAAAACGTGGATTTGCTTTGT
AAACTTGAGAATACATTTTGTTGCCAACAAAAAGAGAGAAGAGAAGAGGAAGATATTGAA
GAGAAGAAATCGATTAAGAAAAAAATTAAAGAACTTAAGTTTTTAGATTCTAAAATTGCC
CAGAACCTTTCAATCTTCCTGAGCTCTTTTCGGGTGCCATATGAGGAAATCAGAATGATG
ATATTGGAAGTAGATGAAACACGGTTGGCAGAGTCTATGATTCAGAACTTAATAAAGCAT
CTTCCTGATCAAGAGCAATTAAATTCATTGTCTCAGTTCAAGAGTGAATATAGCAACTTA
TGTGAACCTGAGCAGTTTGTGGTTGTGATGAGCAATGTGAAGAGACTACGGCCACGGCTC
AGTGCTATTCTCTTTAAGCTTCAGTTTGAAGAGCAGGTGAACAACATCAAACCTGACATC
ATGGCTGTCAGTACTGCCTGCGAAGAGATAAAGAAGAGCAAAAGCTTTAGCAAGTTGCTG
GAACTTGTATTGCTAATGGGAAACTACATGAATGCTGGCTCCCGGAATGCTCAAACCTTC
GGATTTAACCTTAGCTCTCTCTGTAAACTAAAGGACACAAAATCAGCAGATCAGAAAACA
ACGCTACTTCATTTCCTGGTAGAAATATGTGAAGAGAAGTACCCTGATATACTGAATTTT
GTGGATGATTTGGAACCTTTAGACAAAGCTAGTAAAGTCTCTGTAGAAACGCTGGAAAAG
AATTTGAGGCAGATGGGAAGGCAGCTTCAACAGCTTGAGAAGGAATTGGAAACCTTTCCC
CCTCCTGAGGACTTGCATGACAAGTTTGTGACAAAGATGTCCAGATTTGTTATCAGTGCA
AAAGAACAATATGAGACACTTTCGAAGTTACACGAAAACATGGAAAAGTTATACCAGAGT
ATAATAGGATACTATGCCATTGATGTGAAGAAGGTGTCTGTGGAAGACTTTCTTACTGAC
CTGAATAACTTCAGAACCACATTCATGCAAGCAATAAAGGAGAATATCAAAAAAAGAGAA
GCAGAGGAAAAAGAAAAACGTGTCAGAATAGCTAAAGAATTAGCAGAGCGAGAAAGACTC
GAACGCCAACAAAAGAAAAAGCGTTTATTAGAAATGAAGACTGAGGGTGATGAGACAGGA
GTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAAAA
AGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTT
CTGAAAGTTTGTAACCATGAAAATCAGAAAGTGCAGTTGACAGAAGGGTCACGTTCACAC
TACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATCTA
GACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTA
GAAAGCAACAGAAAAAAGGAAACGGAACTTCTTGGCTCTTTTTCTAAAAATGAATCAGTT
CCCGAAGTTGAAGCCCTGCTGGCAAGATTACGAGCTTTATAA
|
| Protein Properties |
|---|
| Number of Residues
| 1193 |
| Molecular Weight
| 136924.6 |
| Theoretical pI
| 7.04 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Protein diaphanous homolog 3
MERHQPRLHHPAQGSAAGTPYPSSASLRGCRESKMPRRKGPQHPPPPSGPEEPGEKRPKF
HLNIRTLTDDMLDKFASIRIPGSKKERPPLPNLKTAFASSDCSAAPLEMMENFPKPLSEN
ELLELFEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQYINTASKTGSLKRSRQISPQEFI
HELKMGSADERLVTCLESLRVSLTSNPVSWVESFGHEGLGLLLDILEKLISGKIQEKVVK
KNQHKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGE
ESILEEVLEALTSAGEEKKIDRFFCIVEGLRHNSVQLQVACMQLINALVTSPDDLDFRLH
IRNEFMRCGLKEILPNLKCIKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDV
YNMVWSTVKETRAEGYFISILQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFT
YRKRLDLDLTQFVDICIDQAKLEEFEEKASELYKKFEKEFTDHQETQAELQKKEAKINEL
QAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLP
GMRMPFSGPVPPPPPLGFLGGQNSPPLPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMT
ENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIA
QNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNL
CEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLL
ELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNF
VDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISA
KEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKRE
AEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEGDETGVMDNLLEALQSGAAFRDRRK
RTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNL
DTHTSTGRIKAAEKKEACNVESNRKKETELLGSFSKNESVPEVEALLARLRAL
|
| External Links |
|---|
| GenBank ID Protein
| 110225351 |
| UniProtKB/Swiss-Prot ID
| Q9NSV4 |
| UniProtKB/Swiss-Prot Entry Name
| DIAP3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001042517.1 |
| GeneCard ID
| DIAPH3 |
| GenAtlas ID
| DIAPH3 |
| HGNC ID
| HGNC:15480 |
| References |
|---|
| General References
| Not Available |