| Identification |
|---|
| HMDB Protein ID
| CDBP03548 |
| Secondary Accession Numbers
| Not Available |
| Name
| Coatomer subunit gamma-2 |
| Description
| Not Available |
| Synonyms
|
- Gamma-2-COP
- Gamma-2-coat protein
|
| Gene Name
| COPG2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors |
| GO Classification
|
| Component |
| cytoplasmic vesicle |
| cytoplasmic membrane-bounded vesicle |
| membrane coat |
| macromolecular complex |
| protein complex |
| organelle |
| vesicle coat |
| copi vesicle coat |
| golgi-associated vesicle |
| vesicle |
| Function |
| structural molecule activity |
| protein binding |
| binding |
| Process |
| establishment of localization |
| transport |
| protein transport |
| intracellular protein transport |
| vesicle-mediated transport |
|
| Cellular Location
|
- Cytoplasm
- Golgi apparatus membrane
- Peripheral membrane protein
- Peripheral membrane protein
- Cytoplasmic vesicle
- Cytoplasmic side
- Cytoplasmic side
- COPI-coated vesicle membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:7 |
| Locus
| 7q32 |
| SNPs
| COPG2 |
| Gene Sequence
|
>2616 bp
ATGATTAAAAAATTCGACAAGAAGGACGAGGAGTCTGGTAGTGGCTCCAATCCTTTCCAG
CATCTGGAGAAGAGTGCTGTTTTACAGGAGGCTCGTATATTCAATGAAACTCCAATCAAT
CCAAGAAGATGTTTGCATATTCTTACAAAGATTCTTTACTTACTGAACCAGGGTGAACAC
TTTGGAACAACGGAAGCTACAGAAGCCTTCTTTGCAATGACGCGATTGTTTCAATCTAAT
GATCAAACATTGAGGAGAATGTGCTACCTTACCATCAAAGAAATGGCTACCATCTCTGAG
GATGTGATAATTGTCACAAGCAGTCTGACTAAAGACATGACTGGAAAAGAAGATGTATAC
CGAGGCCCGGCCATCAGAGCTCTCTGCAGGATCACCGATGGAACAATGTTGCAAGCCATT
GAAAGATACATGAAGCAGGCCATTGTGGATAAAGTTTCCAGTGTATCCAGTTCAGCACTG
GTATCTTCCCTGCACATGATGAAGATAAGCTATGATGTGGTTAAGCGCTGGATCAATGAA
GCCCAAGAAGCTGCATCAAGTGATAATATTATGGTCCAGTACCATGCATTGGGAGTCCTG
TATCACCTTAGAAAGAATGATCGACTTGCTGTTTCCAAGATGTTGAATAAGTTTACTAAA
TCTGGTCTCAAGTCACAGTTTGCTTACTGCATGCTGATCCGAATTGCCAGTCGCTTACTA
AAAGAAACTGAGGATGGCCATGAAAGTCCACTGTTTGATTTCATTGAGAGCTGCTTGCGA
AATAAACATGAAATGGTTATTTATGAAGCTGCTTCAGCTATCATCCATCTTCCTAACTGC
ACTGCAAGAGAGTTGGCACCTGCTGTTTCAGTTCTTCAACTTTTCTGTAGTTCTCCTAAG
CCAGCCTTGAGATATGCAGCTGTGAGGACCTTGAACAAGGTGGCAATGAAGCACCCCTCT
GCTGTTACTGCCTGCAATCTGGACTTAGAAAACTTAATCACAGACTCAAACAGAAGCATT
GCTACCTTAGCCATTACTACACTCCTCAAAACAGGAAGTGAGAGCAGTGTGGACCGGCTC
ATGAAGCAGATATCTTCTTTTGTGTCTGAAATCTCAGATGAGTTCAAGGTGGTGGTTGTA
CAGGCAATTAGTGCTCTCTGTCAGAAATACCCTCGAAAGCACAGTGTCATGATGACTTTC
CTCTCCAACATGCTCCGAGATGATGGAGGCTTTGAGTACAAGCGGGCCATTGTGGACTGT
ATAATCAGCATTGTGGAAGAGAACCCTGAGAGTAAAGAAGCAGGCCTAGCCCACCTTTGT
GAATTCATTGAGGACTGTGAACACACTGTTCTGGCTACTAAGATTCTACACTTGTTGGGC
AAAGAGGGCCCTAGAACGCCTGTCCCCTCCAAATATATCCGTTTTATTTTTAATAGGGTT
GTCCTGGAGAATGAGGCTGTCAGAGCTGCTGCTGTGAGTGCTTTGGCTAAATTTGGGGCT
CAGAATGAGAGTCTTCTCCCAAGCATCCTTGTACTCTTACAGAGGTGTATGATGGATACT
GATGACGAGGTACGAGACAGAGCTACCTTCTATCTGAATGTGCTGCAGCAGAGGCAGATG
GCACTAAATGCCACATATATCTTTAATGGTTTGACGGTCTCTGTACCAGGGATGGAAAAA
GCCTTACACCAGTACACGTTGGAGCCTTCAGAAAAACCGTTTGACATGAAATCAATTCCT
CTTGCTATGGCTCCTGTCTTTGAACAGAAAGCAGAAATCACACTTGTGGCTACTAAGCCA
GAGAAGTTGGCTCCTTCCAGGCAAGACATTTTCCAAGAACAATTGGCTGCCATTCCTGAG
TTTCTGAATATAGGACCCTTGTTCAAGTCTTCTGAGCCTGTTCAACTTACAGAAGCAGAG
ACAGAATATTTTGTTCGATGTATCAAGCACATGTTTACCAATCACATCGTGTTCCAGTTT
GACTGCACCAACACTCTCAATGACCAGCTGCTGGAAAAAGTGACAGTGCAGATGGAGCCA
TCAGATTCCTATGAAGTGCTGTCTTGTATCCCAGCCCCCAGCCTTCCTTATAACCAACCA
GGAATATGTTACACTCTTGTTCGTTTGCCTGATGATGACCCTACAGCAGTTGCAGGCTCC
TTTAGCTGCACCATGAAGTTTACAGTCCGGGACTGTGACCCTAACACTGGAGTTCCAGAT
GAGGATGGGTATGATGATGAGTATGTGCTGGAAGATCTCGAAGTGACTGTGTCTGACCAT
ATTCAGAAAGTACTGAAGCCTAACTTTGCTGCTGCTTGGGAAGAGGTGGGAGATACCTTT
GAGAAAGAGGAAACCTTTGCCCTCAGTTCTACCAAAACCCTTGAAGAGGCTGTCAACAAT
ATCATCACATTTCTGGGCATGCAGCCATGTGAGAGGTCCGATAAAGTACCTGAGAACAAG
AATTCCCATTCGCTCTATCTGGCAGGTATATTCAGAGGTGGCTATGATTTATTGGTGAGG
TCCAGGCTGGCCTTAGCCGATGGAGTGACCATGCAGGTGACTGTCAGAAGTAAAGAGAGA
ACACCTGTAGATGTTATCTTAGCTTCTGTTGGATAA
|
| Protein Properties |
|---|
| Number of Residues
| 871 |
| Molecular Weight
| 97621.3 |
| Theoretical pI
| 5.58 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Coatomer subunit gamma-2
MIKKFDKKDEESGSGSNPFQHLEKSAVLQEARIFNETPINPRRCLHILTKILYLLNQGEH
FGTTEATEAFFAMTRLFQSNDQTLRRMCYLTIKEMATISEDVIIVTSSLTKDMTGKEDVY
RGPAIRALCRITDGTMLQAIERYMKQAIVDKVSSVSSSALVSSLHMMKISYDVVKRWINE
AQEAASSDNIMVQYHALGVLYHLRKNDRLAVSKMLNKFTKSGLKSQFAYCMLIRIASRLL
KETEDGHESPLFDFIESCLRNKHEMVIYEAASAIIHLPNCTARELAPAVSVLQLFCSSPK
PALRYAAVRTLNKVAMKHPSAVTACNLDLENLITDSNRSIATLAITTLLKTGSESSVDRL
MKQISSFVSEISDEFKVVVVQAISALCQKYPRKHSVMMTFLSNMLRDDGGFEYKRAIVDC
IISIVEENPESKEAGLAHLCEFIEDCEHTVLATKILHLLGKEGPRTPVPSKYIRFIFNRV
VLENEAVRAAAVSALAKFGAQNESLLPSILVLLQRCMMDTDDEVRDRATFYLNVLQQRQM
ALNATYIFNGLTVSVPGMEKALHQYTLEPSEKPFDMKSIPLAMAPVFEQKAEITLVATKP
EKLAPSRQDIFQEQLAAIPEFLNIGPLFKSSEPVQLTEAETEYFVRCIKHMFTNHIVFQF
DCTNTLNDQLLEKVTVQMEPSDSYEVLSCIPAPSLPYNQPGICYTLVRLPDDDPTAVAGS
FSCTMKFTVRDCDPNTGVPDEDGYDDEYVLEDLEVTVSDHIQKVLKPNFAAAWEEVGDTF
EKEETFALSSTKTLEEAVNNIITFLGMQPCERSDKVPENKNSHSLYLAGIFRGGYDLLVR
SRLALADGVTMQVTVRSKERTPVDVILASVG
|
| External Links |
|---|
| GenBank ID Protein
| 11094285 |
| UniProtKB/Swiss-Prot ID
| Q9UBF2 |
| UniProtKB/Swiss-Prot Entry Name
| COPG2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB047847 |
| GeneCard ID
| COPG2 |
| GenAtlas ID
| COPG2 |
| HGNC ID
| HGNC:2237 |
| References |
|---|
| General References
| Not Available |