Identification |
HMDB Protein ID
| CDBP03547 |
Secondary Accession Numbers
| Not Available |
Name
| Coatomer subunit epsilon |
Description
| Not Available |
Synonyms
|
- Epsilon-COP
- Epsilon-coat protein
|
Gene Name
| COPE |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in structural molecule activity |
Specific Function
| The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors |
GO Classification
|
Component |
protein complex |
vesicle coat |
copi vesicle coat |
membrane coat |
macromolecular complex |
Function |
binding |
structural molecule activity |
protein binding |
Process |
establishment of localization |
transport |
golgi vesicle transport |
retrograde vesicle-mediated transport, golgi to er |
vesicle-mediated transport |
|
Cellular Location
|
- Cytoplasm
- Golgi apparatus membrane
- Peripheral membrane protein
- Peripheral membrane protein
- Cytoplasmic vesicle
- Cytoplasmic side
- Cytoplasmic side
- COPI-coated vesicle membrane
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 19p13.11 |
SNPs
| COPE |
Gene Sequence
|
>927 bp
ATGGCGCCTCCGGCCCCCGGCCCGGCCTCCGGCGGCTCCGGGGAGGTAGACGAGCTGTTC
GACGTAAAGAACGCCTTCTACATCGGCAGCTACCAGCAGTGCATAAACGAGGCGCAGCGG
GTGAAGCTATCAAGCCCAGAGAGAGACGTGGAGAGGGACGTCTTCCTGTATAGAGCGTAC
CTGGCGCAGAGGAAGTTCGGTGTGGTCCTGGATGAGATCAAGCCCTCCTCGGCCCCTGAG
CTCCAGGCCGTGCGCATGTTTGCTGACTACCTCGCCCACGAGAGTCGGAGGGACAGCATC
GTGGCCGAGCTGGACCGAGAGATGAGCAGGAGCGTGGACGTGACCAACACCACCTTCCTG
CTCATGGCCGCCTCCATCTATCTCCACGACCAGAACCCGGATGCCGCCCTGCGTGCGCTG
CACCAGGGGGACAGCCTGGAGTGCACAGCCATGACAGTGCAGATCCTGCTGAAGCTGGAC
CGCCTGGACCTCGCCCGGAAGGAGCTGAAGAGAATGCAGGACCTGGACGAGGATGCCACC
CTCACCCAGCTCGCCACTGCCTGGGTCAGCCTGGCCACGGGTGGTGAGAAGCTGCAGGAT
GCCTACTACATCTTCCAGGAGATGGCTGACAAGTGCTCGCCCACCCTGCTGCTGCTCAAT
GGGCAGGCGGCCTGCCACATGGCCCAGGGCCGCTGGGAGGCCGCTGAGGGCCTGCTGCAG
GAGGCGCTAGACAAGGATAGTGGCTACCCAGAGACGCTGGTCAACCTCATCGTCCTGTCC
CAGCACCTGGGCAAGCCCCCTGAGGTGACAAACCGATACCTGTCCCAGCTGAAGGATGCC
CACAGGTCCCATCCCTTCATCAAGGAGTACCAGGCCAAGGAGAACGACTTTGACAGGCTG
GTGCTACAGTACGCTCCCAGCGCCTGA
|
Protein Properties |
Number of Residues
| 308 |
Molecular Weight
| 34481.6 |
Theoretical pI
| 4.75 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Coatomer subunit epsilon
MAPPAPGPASGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPERDVERDVFLYRAY
LAQRKFGVVLDEIKPSSAPELQAVRMFADYLAHESRRDSIVAELDREMSRSVDVTNTTFL
LMAASIYLHDQNPDAALRALHQGDSLECTAMTVQILLKLDRLDLARKELKRMQDLDEDAT
LTQLATAWVSLATGGEKLQDAYYIFQEMADKCSPTLLLLNGQAACHMAQGRWEAAEGLLQ
EALDKDSGYPETLVNLIVLSQHLGKPPEVTNRYLSQLKDAHRSHPFIKEYQAKENDFDRL
VLQYAPSA
|
External Links |
GenBank ID Protein
| 31542319 |
UniProtKB/Swiss-Prot ID
| O14579 |
UniProtKB/Swiss-Prot Entry Name
| COPE_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| NM_007263.3 |
GeneCard ID
| COPE |
GenAtlas ID
| COPE |
HGNC ID
| HGNC:2234 |
References |
General References
| Not Available |