Identification
HMDB Protein ID CDBP03545
Secondary Accession Numbers Not Available
Name Coatomer subunit beta
Description Not Available
Synonyms
  1. Beta-COP
  2. Beta-coat protein
Gene Name COPB1
Protein Type Enzyme
Biological Properties
General Function Involved in binding
Specific Function The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors
GO Classification
Component
membrane coat
cell part
intracellular part
cytoplasm
macromolecular complex
protein complex
vesicle coat
copi vesicle coat
Function
binding
structural molecule activity
protein binding
Process
intracellular protein transport
vesicle-mediated transport
establishment of localization
transport
protein transport
Cellular Location
  1. Cytoplasm
  2. Golgi apparatus membrane
  3. Peripheral membrane protein
  4. Peripheral membrane protein
  5. Cytoplasmic vesicle
  6. Cytoplasmic side
  7. Cytoplasmic side
  8. COPI-coated vesicle membrane
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 11p15.2
SNPs COPB1
Gene Sequence
>2862 bp
ATGACGGCGGCTGAGAACGTATGCTACACGTTAATTAACGTGCCAATGGATTCAGAACCA
CCATCTGAAATTAGCTTAAAAAATGATCTAGAAAAAGGAGATGTAAAGTCAAAGACTGAA
GCTTTGAAGAAAGTAATCATTATGATTCTGAATGGTGAAAAACTTCCTGGACTTCTGATG
ACCATCATTCGTTTTGTGCTACCTCTTCAGGATCACACTATCAAGAAATTACTTCTGGTA
TTTTGGGAAATTGTTCCTAAAACAACTCCAGATGGGAGACTTTTACATGAGATGATCCTT
GTATGTGATGCATACAGAAAGGATCTTCAACATCCTAATGAATTTATTCGAGGATCTACT
CTTCGTTTTCTTTGCAAATTGAAAGAAGCAGAATTGCTAGAACCTTTAATGCCAGCTATT
CGTGCATGTTTGGAGCATCGACACAGCTATGTTAGAAGAAATGCTGTTTTGGCCATCTAT
ACCATCTATAGAAATTTTGAACATCTTATACCTGATGCTCCTGAACTGATACATGATTTT
CTGGTGAATGAGAAGGATGCAAGTTGCAAAAGGAATGCATTTATGATGCTAATTCATGCA
GATCAGGATCGAGCTTTGGATTACTTAAGTACTTGCATTGATCAAGTTCAAACATTTGGA
GACATTCTGCAGCTGGTTATTGTTGAACTGATTTATAAGGTCTGTCATGCTAATCCATCA
GAAAGAGCTCGTTTTATTCGCTGCATCTATAACTTATTACAGTCATCCAGCCCTGCTGTA
AAATATGAAGCTGCTGGGACATTAGTGACACTCTCTAGTGCACCAACTGCAATCAAGGCT
GCTGCTCAGTGTTACATTGATTTAATTATTAAGGAGAGCGACAACAATGTAAAACTCATA
GTTTTGGATCGCTTGATAGAATTAAAAGAGCATCCTGCTCATGAACGAGTACTACAGGAT
CTGGTTATGGATATCCTAAGAGTATTGAGCACACCAGACTTAGAAGTACGAAAGAAAACT
CTGCAGTTAGCACTGGATCTTGTCTCTTCTAGAAATGTTGAAGAGCTGGTTATTGTCCTG
AAGAAGGAAGTGATTAAAACAAATAATGTGTCTGAGCATGAAGATACTGACAAATACAGA
CAACTCCTAGTGCGAACATTGCATTCCTGTTCTGTCCGATTTCCAGATATGGCTGCAAAT
GTTATTCCTGTGTTAATGGAATTTCTCAGTGACAACAACGAAGCAGCAGCTGCTGATGTC
TTGGAGTTTGTTCGTGAAGCCATTCAGCGCTTTGATAACCTGAGAATGCTTATTGTTGAG
AAGATGCTTGAAGTCTTTCATGCTATTAAATCTGTCAAGATTTACCGAGGAGCATTATGG
ATCCTGGGAGAATACTGTAGTACCAAGGAAGACATTCAGAGTGTGATGACTGAGATCCGC
AGGTCCCTTGGAGAGATCCCAATTGTAGAGTCAGAAATAAAGAAAGAAGCTGGTGAATTA
AAACCTGAAGAAGAAATAACTGTAGGGCCAGTTCAGAAATTGGTTACTGAAATGGGTACC
TATGCAACTCAGAGTGCCCTTAGCAGTTCTAGACCCACCAAGAAAGAGGAAGACAGACCT
CCCTTGAGAGGATTCCTTCTGGATGGAGATTTCTTTGTTGCTGCCTCCCTTGCCACAACT
CTGACCAAGATTGCATTGCGCTATGTAGCTTTGGTTCAGGAGAAGAAAAAGCAAAATTCT
TTTGTTGCTGAGGCTATGTTGCTCATGGCTACTATCCTGCATTTGGGAAAATCCTCTCTT
CCTAAGAAGCCAATTACTGATGATGATGTGGATCGAATTTCCCTGTGCCTCAAGGTCTTG
TCTGAATGTTCACCTTTAATGAATGACATTTTCAATAAGGAATGCAGACAGTCCCTTTCT
CACATGTTATCTGCTAAACTAGAAGAAGAGAAATTATCCCAAAAGAAAGAATCTGAAAAG
AGGAATGTGACAGTACAGCCTGATGACCCCATTTCCTTCATGCAACTAACTGCTAAGAAT
GAAATGAACTGCAAGGAAGATCAGTTTCAGCTGAGTTTACTGGCAGCAATGGGTAACACA
CAGAGGAAAGAGGCAGCAGATCCCCTAGCATCTAAACTTAACAAGGTCACCCAATTGACA
GGTTTCTCAGATCCTGTATATGCAGAAGCTTACGTTCATGTCAACCAATATGATATTGTC
CTGGATGTACTTGTTGTGAACCAAACCAGTGATACTTTGCAGAATTGCACATTAGAACTA
GCTACACTAGGGGATCTGAAACTTGTGGAAAAGCCGTCTCCTTTGACTCTTGCTCCTCAT
GACTTCGCAAATATTAAAGCTAACGTCAAAGTAGCATCAACAGAAAATGGAATAATTTTT
GGTAATATAGTTTATGATGTCTCTGGAGCAGCAAGTGACAGAAATTGTGTGGTCCTCAGT
GATATTCACATCGAAATCATGGACTATATCCAGCCTGCAACTTGCACTGATGCAGAATTC
CGTCAGATGTGGGCCGAATTGGAATGGGAAAACAAAGTGACAGTTAACACCAACATGGTT
GATTTAAATGACTACTTACAGCACATATTAAAGTCAACCAATATGAAATGCCTGACTCCA
GAAAAGGCCCTTTCTGGTTACTGTGGCTTTATGGCAGCCAACCTTTATGCTCGCTCCATA
TTTGGTGAAGATGCACTTGCAAATGTCAGCAGTGAGAAGCCATTACACCAGGGACCAGAT
GCTGCTGTTACCGTCCATATAAGAATTCGTGCAAAGAGCCAGGGAATGGCCTTAAGTCTT
GGAGATAAAATCAACTTGTCACAGAAGGAAACTAGTATATAA
Protein Properties
Number of Residues 953
Molecular Weight 107141.1
Theoretical pI 5.92
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Coatomer subunit beta
MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM
TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST
LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDF
LVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPS
ERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLI
VLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVL
KKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAADV
LEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIQSVMTEIR
RSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRP
PLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILHLGKSSL
PKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEK
RNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLT
GFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPH
DFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEF
RQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSI
FGEDALANVSIEKPIHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKTSI
GenBank ID Protein 5257007
UniProtKB/Swiss-Prot ID P53618
UniProtKB/Swiss-Prot Entry Name COPB_HUMAN
PDB IDs Not Available
GenBank Gene ID AF084457
GeneCard ID COPB1
GenAtlas ID COPB1
HGNC ID HGNC:2231
References
General References Not Available