| Identification |
|---|
| HMDB Protein ID
| CDBP03545 |
| Secondary Accession Numbers
| Not Available |
| Name
| Coatomer subunit beta |
| Description
| Not Available |
| Synonyms
|
- Beta-COP
- Beta-coat protein
|
| Gene Name
| COPB1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors |
| GO Classification
|
| Component |
| membrane coat |
| cell part |
| intracellular part |
| cytoplasm |
| macromolecular complex |
| protein complex |
| vesicle coat |
| copi vesicle coat |
| Function |
| binding |
| structural molecule activity |
| protein binding |
| Process |
| intracellular protein transport |
| vesicle-mediated transport |
| establishment of localization |
| transport |
| protein transport |
|
| Cellular Location
|
- Cytoplasm
- Golgi apparatus membrane
- Peripheral membrane protein
- Peripheral membrane protein
- Cytoplasmic vesicle
- Cytoplasmic side
- Cytoplasmic side
- COPI-coated vesicle membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11p15.2 |
| SNPs
| COPB1 |
| Gene Sequence
|
>2862 bp
ATGACGGCGGCTGAGAACGTATGCTACACGTTAATTAACGTGCCAATGGATTCAGAACCA
CCATCTGAAATTAGCTTAAAAAATGATCTAGAAAAAGGAGATGTAAAGTCAAAGACTGAA
GCTTTGAAGAAAGTAATCATTATGATTCTGAATGGTGAAAAACTTCCTGGACTTCTGATG
ACCATCATTCGTTTTGTGCTACCTCTTCAGGATCACACTATCAAGAAATTACTTCTGGTA
TTTTGGGAAATTGTTCCTAAAACAACTCCAGATGGGAGACTTTTACATGAGATGATCCTT
GTATGTGATGCATACAGAAAGGATCTTCAACATCCTAATGAATTTATTCGAGGATCTACT
CTTCGTTTTCTTTGCAAATTGAAAGAAGCAGAATTGCTAGAACCTTTAATGCCAGCTATT
CGTGCATGTTTGGAGCATCGACACAGCTATGTTAGAAGAAATGCTGTTTTGGCCATCTAT
ACCATCTATAGAAATTTTGAACATCTTATACCTGATGCTCCTGAACTGATACATGATTTT
CTGGTGAATGAGAAGGATGCAAGTTGCAAAAGGAATGCATTTATGATGCTAATTCATGCA
GATCAGGATCGAGCTTTGGATTACTTAAGTACTTGCATTGATCAAGTTCAAACATTTGGA
GACATTCTGCAGCTGGTTATTGTTGAACTGATTTATAAGGTCTGTCATGCTAATCCATCA
GAAAGAGCTCGTTTTATTCGCTGCATCTATAACTTATTACAGTCATCCAGCCCTGCTGTA
AAATATGAAGCTGCTGGGACATTAGTGACACTCTCTAGTGCACCAACTGCAATCAAGGCT
GCTGCTCAGTGTTACATTGATTTAATTATTAAGGAGAGCGACAACAATGTAAAACTCATA
GTTTTGGATCGCTTGATAGAATTAAAAGAGCATCCTGCTCATGAACGAGTACTACAGGAT
CTGGTTATGGATATCCTAAGAGTATTGAGCACACCAGACTTAGAAGTACGAAAGAAAACT
CTGCAGTTAGCACTGGATCTTGTCTCTTCTAGAAATGTTGAAGAGCTGGTTATTGTCCTG
AAGAAGGAAGTGATTAAAACAAATAATGTGTCTGAGCATGAAGATACTGACAAATACAGA
CAACTCCTAGTGCGAACATTGCATTCCTGTTCTGTCCGATTTCCAGATATGGCTGCAAAT
GTTATTCCTGTGTTAATGGAATTTCTCAGTGACAACAACGAAGCAGCAGCTGCTGATGTC
TTGGAGTTTGTTCGTGAAGCCATTCAGCGCTTTGATAACCTGAGAATGCTTATTGTTGAG
AAGATGCTTGAAGTCTTTCATGCTATTAAATCTGTCAAGATTTACCGAGGAGCATTATGG
ATCCTGGGAGAATACTGTAGTACCAAGGAAGACATTCAGAGTGTGATGACTGAGATCCGC
AGGTCCCTTGGAGAGATCCCAATTGTAGAGTCAGAAATAAAGAAAGAAGCTGGTGAATTA
AAACCTGAAGAAGAAATAACTGTAGGGCCAGTTCAGAAATTGGTTACTGAAATGGGTACC
TATGCAACTCAGAGTGCCCTTAGCAGTTCTAGACCCACCAAGAAAGAGGAAGACAGACCT
CCCTTGAGAGGATTCCTTCTGGATGGAGATTTCTTTGTTGCTGCCTCCCTTGCCACAACT
CTGACCAAGATTGCATTGCGCTATGTAGCTTTGGTTCAGGAGAAGAAAAAGCAAAATTCT
TTTGTTGCTGAGGCTATGTTGCTCATGGCTACTATCCTGCATTTGGGAAAATCCTCTCTT
CCTAAGAAGCCAATTACTGATGATGATGTGGATCGAATTTCCCTGTGCCTCAAGGTCTTG
TCTGAATGTTCACCTTTAATGAATGACATTTTCAATAAGGAATGCAGACAGTCCCTTTCT
CACATGTTATCTGCTAAACTAGAAGAAGAGAAATTATCCCAAAAGAAAGAATCTGAAAAG
AGGAATGTGACAGTACAGCCTGATGACCCCATTTCCTTCATGCAACTAACTGCTAAGAAT
GAAATGAACTGCAAGGAAGATCAGTTTCAGCTGAGTTTACTGGCAGCAATGGGTAACACA
CAGAGGAAAGAGGCAGCAGATCCCCTAGCATCTAAACTTAACAAGGTCACCCAATTGACA
GGTTTCTCAGATCCTGTATATGCAGAAGCTTACGTTCATGTCAACCAATATGATATTGTC
CTGGATGTACTTGTTGTGAACCAAACCAGTGATACTTTGCAGAATTGCACATTAGAACTA
GCTACACTAGGGGATCTGAAACTTGTGGAAAAGCCGTCTCCTTTGACTCTTGCTCCTCAT
GACTTCGCAAATATTAAAGCTAACGTCAAAGTAGCATCAACAGAAAATGGAATAATTTTT
GGTAATATAGTTTATGATGTCTCTGGAGCAGCAAGTGACAGAAATTGTGTGGTCCTCAGT
GATATTCACATCGAAATCATGGACTATATCCAGCCTGCAACTTGCACTGATGCAGAATTC
CGTCAGATGTGGGCCGAATTGGAATGGGAAAACAAAGTGACAGTTAACACCAACATGGTT
GATTTAAATGACTACTTACAGCACATATTAAAGTCAACCAATATGAAATGCCTGACTCCA
GAAAAGGCCCTTTCTGGTTACTGTGGCTTTATGGCAGCCAACCTTTATGCTCGCTCCATA
TTTGGTGAAGATGCACTTGCAAATGTCAGCAGTGAGAAGCCATTACACCAGGGACCAGAT
GCTGCTGTTACCGTCCATATAAGAATTCGTGCAAAGAGCCAGGGAATGGCCTTAAGTCTT
GGAGATAAAATCAACTTGTCACAGAAGGAAACTAGTATATAA
|
| Protein Properties |
|---|
| Number of Residues
| 953 |
| Molecular Weight
| 107141.1 |
| Theoretical pI
| 5.92 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Coatomer subunit beta
MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM
TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST
LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDF
LVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPS
ERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLI
VLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVL
KKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAADV
LEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIQSVMTEIR
RSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRP
PLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILHLGKSSL
PKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEK
RNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLT
GFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPH
DFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEF
RQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSI
FGEDALANVSIEKPIHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKTSI
|
| External Links |
|---|
| GenBank ID Protein
| 5257007 |
| UniProtKB/Swiss-Prot ID
| P53618 |
| UniProtKB/Swiss-Prot Entry Name
| COPB_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF084457 |
| GeneCard ID
| COPB1 |
| GenAtlas ID
| COPB1 |
| HGNC ID
| HGNC:2231 |
| References |
|---|
| General References
| Not Available |