| Identification |
|---|
| HMDB Protein ID
| CDBP03542 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cdc42-interacting protein 4 |
| Description
| Not Available |
| Synonyms
|
- Protein Felic
- Salt tolerant protein
- TR-interacting protein 10
- TRIP-10
- Thyroid receptor-interacting protein 10
- hSTP
|
| Gene Name
| TRIP10 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in identical protein binding |
| Specific Function
| Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N- WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL |
| GO Classification
|
Not Available
|
| Cellular Location
|
- perinuclear region
- Isoform 5:Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19p13.3 |
| SNPs
| TRIP10 |
| Gene Sequence
|
>1806 bp
ATGGATTGGGGCACTGAGCTGTGGGATCAGTTCGAGGTGCTCGAGCGCCACACGCAGTGG
GGGCTGGACCTGTTGGACAGATATGTAAAGTTCGTGAAAGAACGCACCGAAGTGGAACAG
GCTTACGCCAAACAACTGCGGAGCCTGGTGAAAAAATATCTGCCCAAGAGACCTGCCAAG
GATGATCCTGAGTCCAAATTCAGCCAGCAACAGTCCTTCGTACAGATTCTCCAGGAGGTG
AATGACTTTGCAGGCCAGCGGGAGCTGGTGGCTGAGAACCTCAGTGTCCGTGTATGTCTT
GAGCTGACCAAGTACTCACAAGAGATGAAACAGGAGAGGAAGATGCACTTCCAAGAAGGG
CGGCGGGCCCAGCAGCAGCTGGAAAATGGCTTTAAACAGCTGGAGAATAGTAAGCGTAAA
TTTGAGCGGGACTGCCGGGAGGCAGAGAAGGCAGCCCAGACTGCTGAACGGCTAGACCAG
GATATCAACGCCACCAAGGCTGATGTGGAGAAGGCCAAGCAGCAAGCCCACCTTCGGAGT
CACATGGCCGAAGAAAGCAAAAACGAATATGCGGCTCAACTGCAGCGCTTCAACCGAGAC
CAAGCCCACTTCTATTTTTCACAGATGCCCCAGATATTCGATAAGCTCCAAGACATGGAT
GAACGCAGGGCCACCCGCCTGGGTGCCGGGTATGGGCTCCTGTCGGAGGCCGAGCTGGAG
GTGGTGCCCATAATAGCCAAGTGCTTGGAGGGCATGAAGGTGGCTGCAAATGCTGTGGAT
CCCAAGAACGACTCCCACGTCCTTATAGAGCTGCACAAGTCAGGTTTTGCCCGCCCGGGC
GACGTGGAATTCGAGGACTTCAGCCAGCCCATGAACCGTGCACCCTCCGACAGCAGTCTG
GGCACCCCCTCGGATGGACGGCCTGAACTCCGAGGCCCGGGTCGCAGCCGCACCAAGCGC
TGGCCTTTTGGCAAGAAGAACAAGCCTCGCCCCCCACCCCTCTCCCCCCTGGGGGGCCCC
GTACCCTCGGCATTGCCTAACGGACCCCCGTCCCCCCGCTCCGGCCGTGACCCCTTGGCC
ATACTGAGCGAGATCAGTAAGTCGGTCAAACCGAGGCTAGCATCCTTCCGCAGCCTTCGA
GGCAGCCGTGGGACAGTGGTGACCGAGGATTTTAGCCACTTGCCCCCAGAGCAGCAGCGA
AAACGGCTTCAACAGCAGTTGGAAGAACGCAGTCGTGAACTTCAGAAGGAGGTTGACCAG
AGGGAAGCCCTAAAGAAAATGAAGGATGTCTATGAGAAGACACCTCAGATGGGGGACCCC
GCCAGCTTGGAGCCCCAGATCGCTGAAACCCTGAGCAACATTGAACGGCTGAAATTGGAA
GTGCAGAAGTATGAGGCGTGGCTGGCAGAAGCTGAAAGTCGAGTCCTTAGCAACCGGGGA
GACAGCCTGAGCCGGCACGCCCGGCCTCCCGACCCCCCCGCTAGCGCCCCGCCAGACAGC
AGCAGCAACAGCGCATCACAGGACACCAAGGAGAGCTCTGAAGAGCCTCCCTCAGAAGAG
AGCCAGGACACCCCCATTTACACGGAGTTTGATGAGGATTTCGAGGAGGAACCCACATCC
CCCATAGGTCACTGTGTGGCCATCTACCACTTTGAAGGGTCCAGCGAGGGCACTATCTCT
ATGGCCGAGGGTGAAGACCTCAGTCTTATGGAAGAAGACAAAGGGGACGGCTGGACCCGG
GTCAGGCGGAAAGAGGGAGGCGAGGGCTACGTGCCCACCTCCTACCTCCGAGTCACGCTC
AATTGA
|
| Protein Properties |
|---|
| Number of Residues
| 601 |
| Molecular Weight
| 68351.7 |
| Theoretical pI
| 5.45 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cdc42-interacting protein 4
MDWGTELWDQFEVLERHTQWGLDLLDRYVKFVKERTEVEQAYAKQLRSLVKKYLPKRPAK
DDPESKFSQQQSFVQILQEVNDFAGQRELVAENLSVRVCLELTKYSQEMKQERKMHFQEG
RRAQQQLENGFKQLENSKRKFERDCREAEKAAQTAERLDQDINATKADVEKAKQQAHLRS
HMAEESKNEYAAQLQRFNRDQAHFYFSQMPQIFDKLQDMDERRATRLGAGYGLLSEAELE
VVPIIAKCLEGMKVAANAVDPKNDSHVLIELHKSGFARPGDVEFEDFSQPMNRAPSDSSL
GTPSDGRPELRGPGRSRTKRWPFGKKNKPRPPPLSPLGGPVPSALPNGPPSPRSGRDPLA
ILSEISKSVKPRLASFRSLRGSRGTVVTEDFSHLPPEQQRKRLQQQLEERSRELQKEVDQ
REALKKMKDVYEKTPQMGDPASLEPQIAETLSNIERLKLEVQKYEAWLAEAESRVLSNRG
DSLSRHARPPDPPASAPPDSSSNSASQDTKESSEEPPSEESQDTPIYTEFDEDFEEEPTS
PIGHCVAIYHFEGSSEGTISMAEGEDLSLMEEDKGDGWTRVRRKEGGEGYVPTSYLRVTL
N
|
| External Links |
|---|
| GenBank ID Protein
| 21311785 |
| UniProtKB/Swiss-Prot ID
| Q15642 |
| UniProtKB/Swiss-Prot Entry Name
| CIP4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF502289 |
| GeneCard ID
| TRIP10 |
| GenAtlas ID
| TRIP10 |
| HGNC ID
| HGNC:12304 |
| References |
|---|
| General References
| Not Available |