| Identification |
|---|
| HMDB Protein ID
| CDBP03535 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cdc42 effector protein 5 |
| Description
| Not Available |
| Synonyms
|
- Binder of Rho GTPases 3
|
| Gene Name
| CDC42EP5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in GTP-Rho binding |
| Specific Function
| Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42 |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Cytoplasm
- Endomembrane system
- Peripheral membrane protein
- cytoskeleton
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19q13.42 |
| SNPs
| CDC42EP5 |
| Gene Sequence
|
>447 bp
ATGCCCGTGCTGAAGCAGCTGGGCCCCGCGCAGCCCAAGAAGCGGCCTGATCGCGGCGCC
CTGTCCATCTCCGCGCCGCTCGGCGACTTCCGGCACACGCTGCACGTGGGGCGCGGCGGC
GACGCCTTCGGGGACACCTCGTTCCTGAGCCGCCACGGCGGCGGGCCGCCCCCCCAGCCC
CGGGCGCCCCCCGCGGGGGCCCCGCGCTCCCCGCCGCCGCCCGCCGTCCCGCAGTCCGCA
GCGCCCTCGCCTGCCGACCCGCTGCTGTCCTTCCACCTGGATCTGGGGCCCTCCATGCTG
GACGCGGTGCTGGGCGTCATGGACGCGGCGCGCCCGGAGGCGGCTGCCGCCAAGCCCGAC
GCGGAACCCCGCCCCGGGACGCAGCCCCCCCAGGCCCGCTGCCGCCCCAACGCGGACCTC
GAGCTGAACGACGTCATCGGCCTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 148 |
| Molecular Weight
| 15207.1 |
| Theoretical pI
| 7.69 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cdc42 effector protein 5
MPVLKQLGPAQPKKRPDRGALSISAPLGDFRHTLHVGRGGDAFGDTSFLSRHGGGPPPEP
RAPPAGAPRSPPPPAVPQSAAPSPADPLLSFHLDLGPSMLDAVLGVMDAARPEAAAAKPD
AEPRPGTQPPQARCRPNADLELNDVIGL
|
| External Links |
|---|
| GenBank ID Protein
| 19354244 |
| UniProtKB/Swiss-Prot ID
| Q6NZY7 |
| UniProtKB/Swiss-Prot Entry Name
| BORG3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC024327 |
| GeneCard ID
| CDC42EP5 |
| GenAtlas ID
| CDC42EP5 |
| HGNC ID
| HGNC:17408 |
| References |
|---|
| General References
| Not Available |