Identification |
HMDB Protein ID
| CDBP03532 |
Secondary Accession Numbers
| Not Available |
Name
| Brefeldin A-inhibited guanine nucleotide-exchange protein 2 |
Description
| Not Available |
Synonyms
|
- Brefeldin A-inhibited GEP 2
|
Gene Name
| ARFGEF2 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in binding |
Specific Function
| Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP |
GO Classification
|
Component |
cell part |
intracellular |
Function |
small gtpase regulator activity |
binding |
enzyme regulator activity |
arf guanyl-nucleotide exchange factor activity |
nucleoside-triphosphatase regulator activity |
gtpase regulator activity |
Process |
regulation of biological process |
regulation of arf protein signal transduction |
regulation of cellular process |
regulation of cell communication |
regulation of signal transduction |
regulation of small gtpase mediated signal transduction |
regulation of ras protein signal transduction |
biological regulation |
|
Cellular Location
|
Not Available
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:2 |
Locus
| 20q13.13 |
SNPs
| ARFGEF2 |
Gene Sequence
|
>5358 bp
ATGCAGGAGAGCCAGACCAAGAGCATGTTCGTGTCCCGGGCCCTGGAGAAGATCCTAGCC
GACAAGGAGGTGAAGCGGCCCCAGCACTCCCAGCTGCGCAGGGCCTGCCAGGTGGCGCTC
GATGAAATTAAAGCAGAAATAGAAAAGCAGAGGCTTGGCACTGCTGCACCACCAAAGGCA
AACTTCATTGAAGCTGACAAGTATTTTCTTCCATTCGAGCTAGCTTGCCAGTCCAAGTCC
CCAAGGGTAGTCAGCACATCCCTTGACTGCTTGCAGAAACTCATCGCATACGGGCACATC
ACTGGCAACGCCCCTGACAGTGGAGCCCCTGGGAAGCGGCTGATCGACAGAATTGTTGAA
ACCATTTGCAGTTGTTTTCAGGGCCCTCAGACTGATGAAGGGGTTCAGTTACAAATAATT
AAGGCTCTTCTGACTGCAGTGACTTCCCCACACATTGAAATTCATGAGGGTACTATCCTG
CAGACAGTGAGAACATGTTACAATATCTATTTGGCCAGCAAAAATCTCATCAATCAAACC
ACTGCCAAGGCTACCCTTACTCAGATGCTGAACGTCATTTTCACCCGCATGGAAAACCAA
GTGTTGCAGGAGGCCAGAAGACTGGAAAAACCAATCCAGTCAAAACCCCAGTCCCCTGTG
ATCCAAGCTGCAGCAGTATCCCCAAAGTTCGTTCGTTTGAAGCACAGTCAGGCACAAAGC
AAACCAACAACTCCCGAAAAAACAGATTTAACCAACGGTGAACATGCCAGGAGTGATTCT
GGAAAAGTAAGCACAGAAAATGGAGACGCACCCAGAGAAAGAGGCTCATCACTGTCAGGG
ACTGATGACGGAGCCCAGGAGGTGGTGAAGGACATCTTGGAAGATGTAGTCACATCTGCC
ATTAAAGAAGCAGCGGAAAAGCATGGTCTGACAGAACCTGAGAGAGTTCTAGGTGAACTG
GAGTGCCAGGAATGTGCTATTCCCCCAGGAGTTGATGAAAACTCACAGACCAACGGGATA
GCCGATGACAGGCAGTCCTTGTCGTCAGCAGATAATCTGGAATCGGATGCACAAGGACAT
CAAGTGGCTGCCAGGTTCTCCCACGTTCTGCAGAAGGATGCCTTCCTTGTGTTCCGCTCC
CTGTGCAAGCTGTCCATGAAACCCCTTGGTGAAGGCCCTCCAGACCCAAAATCCCATGAG
CTGCGTTCCAAGGTGGTTTCCCTGCAGCTGCTCCTCTCTGTGTTGCAAAATGCTGGCCCC
GTATTCAGGACTCACGAGATGTTCATCAATGCAATCAAGCAATATCTCTGTGTGGCCTTG
TCCAAAAACGGCGTCTCTTCAGTGCCTGATGTCTTTGAGCTCTCTCTTGCCATTTTTCTT
ACTCTTCTTTCAAACTTTAAAATGCACTTGAAAATGCAGATAGAGGTCTTTTTCAAAGAG
ATTTTCCTGAACATTTTAGAAACATCAACAAGTTCTTTTGAGCACAGGTGGATGGTCATT
CAGACTCTGACGAGGATCTGTGCAGATGCCCAGTGTGTTGTGGATATTTATGTCAACTAC
GACTGTGATTTAAATGCTGCTAACATTTTTGAGCGCCTTGTAAATGATTTATCCAAAATT
GCTCAGGGAAGAAGTGGACATGAGCTGGGAATGACACCTCTGCAGGAGCTCAGCCTGAGG
AAGAAAGGCCTGGAGTGCCTCGTGTCCATTCTCAAGTGCATGGTGGAGTGGAGCAAAGAC
CTGTATGTGAATCCCAACCACCAGACCAGCCTCGGTCAGGAGAGGCTCACGGATCAGGAA
ATAGGGGATGGGAAAGGCCTTGACATGGCAAGACGGTGTAGTGTGACGTCCATGGAGTCC
ACAGTGTCCTCGGGGACCCAGACAACTGTTCAGGATGACCCTGAGCAATTTGAGGTCATC
AAGCAACAAAAAGAAATCATTGAACACGGCATCGAGCTGTTCAACAAGAAACCCAAGAGG
GGGATCCAGTTTCTCCAGGAGCAGGGCATGCTGGGAACGTCAGTTGAAGACATAGCCCAA
TTCCTGCACCAGGAGGAGCGCCTGGATTCCACCCAAGTAGGCGATTTTCTGGGAGATAGC
GCAAGGTTCAACAAGGAGGTGATGTATGCCTACGTGGACCAACTTGACTTCTGTGAAAAA
GAATTTGTCTCAGCCCTGCGGACATTCCTAGAAGGTTTCCGCCTACCTGGAGAAGCCCAA
AAGATTGACCGATTAATGGAGAAGTTTGCCGCAAGATACATAGAATGCAACCAAGGGCAA
ACTCTGTTTGCTAGTGCTGACACTGCTTATGTCCTAGCGTATTCAATTATTATGCTGACT
ACAGACTTGCACAGTCCTCAGGTAAAAAATAAAATGACGAAAGAGCAGTATATTAAAATG
AATCGGGGTATCAATGATAGTAAAGATCTGCCAGAAGAGTATCTCTCAAGCATCTATGAA
GAGATAGAAGGCAAGAAAATTGCAATGAAAGAAACAAAAGAGCTAACGATTGCAACCAAA
TCTACTAAGCAGAATGTAGCTAGTGAAAAGCAGCGGCGGCTGCTGTACAACTTAGAGATG
GAGCAAATGGCTAAAACAGCCAAAGCTCTGATGGAGGCTGTGAGCCATGCCAAAGCCCCG
TTTACCAGTGCCACTCACCTGGACCATGTCCGGCCAATGTTCAAACTGGTGTGGACGCCA
CTATTGGCAGCCTACAGCATCGGACTCCAGAACTGTGATGACACTGAAGTGGCCTCCTTG
TGTTTGGAAGGCATCCGATGTGCAATCCGAATCGCCTGCATCTTTGGAATGCAGCTGGAA
CGAGATGCCTATGTTCAGGCTCTTGCTCGCTTCTCCCTACTCACAGCCAGCTCCAGCATC
ACAAAAATGAAGCAGAAAAACATCGACACCATTAAGACGCTTATCACAGTGGCTCACACC
GATGGCAACTACCTTGGGAATTCCTGGCATGAGATCTTGAAATGCATCAGCCAGCTGGAG
CTCGCTCAGCTGATAGGAACCGGTGTGAAGACGCGCTACCTGTCTGGATCTGGGCGTGAA
AGAGAAGGGAGCCTGAAGGGCCACACATTGGCAGGAGAAGAGTTCATGGGCCTTGGCCTC
GGTAATTTGGTGAGTGGCGGAGTGAATAAAAGACAGATGGCCAGCTTCCAAGAATCGGTT
GGTGAGACCAGCTCGCAGAGTGTGGTTGTAGCTGTGGACAGGATTTTTACTGGGTCTACC
AGACTGGATGGAAATGCAATAGTTGACTTTGTCCGCTGGCTGTGTGCTGTGTCCATGGAT
GAACTGGCTTCCCCCCACCATCCTCGCATGTTCAGCTTGCAGAAGATTGTGGAGATATCA
TACTACAACATGAATCGGATCCGACTACAGTGGTCTCGAATATGGCATGTGATTGGAGAT
CACTTCAATAAGGTTGGCTGCAACCCTAATGAAGATGTGGCTATCTTTGCTGTTGACTCA
TTAAGGCAACTCTCCATGAAGTTTCTTGAGAAGGGTGAATTAGCCAACTTCCGTTTCCAG
AAAGATTTTCTGAGGCCCTTTGAGCATATTATGAAGAAAAACAGGTCTCCCACCATCCGG
GACATGGCGATCCGCTGCATTGCCCAGATGGTGAACTCCCAGGCGGCCAACATCCGCTCA
GGCTGGAAGAACATCTTTGCCGTGTTCCACCAGGCAGCCTCTGATCATGATGGGAACATT
GTGGAGCTGGCCTTCCAGACCACTTGCCACATTGTCACAACTATTTTCCAGCACCATTTT
CCTGCAGCCATCGATTCCTTTCAGGATGCTGTGAAGTGCTTATCAGAGTTCGCCTGCAAC
GCCGCTTTCCCTGACACGAGCATGGAAGCGATTCGGCTCATCCGCTTCTGTGGCAAATAC
GTCTCTGAGAGGCCTCGGGTGCTACAAGAATACACAAGTGATGACATGAATGTAGCTCCT
GGTGACAGAGTCTGGGTCCGAGGCTGGTTCCCCATCTTATTCGAACTCTCCTGCATCATT
AATAGATGCAAGTTAGATGTACGAACAAGGGGACTCACAGTCATGTTTGAGATCATGAAG
AGCTATGGCCACACCTTTGAAAAGCACTGGTGGCAGGACCTGTTCAGAATCGTGTTTCGG
ATTTTTGACAATATGAAACTCCCTGAGCAACTGTCAGAGAAATCTGAGTGGATGACAACA
ACCTGCAATCACGCACTTTATGCTATTTGTGATGTTTTTACCCAGTTTTATGAAGCTTTG
AATGAAGTTCTTCTTTCTGATGTATTTGCACAATTGCAGTGGTGTGTCAAACAAGATAAT
GAACAGTTGGCGCGATCAGGTACAAATTGCTTAGAAAACTTAGTAATATCCAATGGAGAG
AAATTCAGTCCTGAAGTCTGGGATGAAACCTGCAACTGTATGTTGGATATTTTCAAAACA
ACCATCCCACATGTTTTGCTGACATGGAGACCTGTAGGAATGGAGGAAGATTCATCAGAA
AAGCATTTGGATGTGGATCTGGACCGCCAGTCTTTAAGCAGCATAGATAAAAATCCCTCT
GAGAGGGGACAGAGCCAGCTCTCTAACCCAACAGATGACAGCTGGAAGGGTAGACCATAC
GCAAATCAGAAACTGTTTGCCAGCCTCCTCATCAAGTGTGTGGTCCAGTTGGAATTGATA
CAGACCATTGACAACATTGTGTTCTACCCTGCGACGAGCAAAAAGGAGGATGCAGAGCAC
ATGGTTGCCGCCCAGCAAGACACGCTGGATGCAGATATCCACATAGAGACGGAGGATCAG
GGCATGTATAAGTACATGTCTTCCCAGCACCTCTTCAAGCTGTTGGACTGTTTGCAGGAA
TCCCATTCATTCTCAAAGGCCTTCAACTCCAATTACGAGCAGCGGACTGTCCTGTGGCGA
GCAGGTTTTAAGGGCAAGTCTAAACCCAATCTTCTAAAACAAGAAACCAGCAGCCTGGCC
TGTTGTTTGAGGATCCTGTTTCGAATGTATGTTGATGAGAACCGCAGGGATTCCTGGGAA
GAAATACAGCAGAGACTTTTAACTGTTTGCAGTGAAGCTCTTGCCTATTTCATCACTGTG
AATTCTGAGAGCCATCGGGAGGCCTGGACAAGTCTCTTGTTGTTACTTCTAACTAAAACC
CTCAAAATAAATGATGAAAAGTTCAAAGCACATGCTTCAATGTACTACCCCTACTTGTGT
GAAATTATGCAGTTTGACCTGATCCCTGAGCTCCGAGCAGTTCTGCGGAAGTTCTTCCTA
CGGATAAGTGTTGTGTATAAGATATGGATACCAGAAGAGCCATCACAGGTACCAGCAGCA
CTGTCACCAGTGTGGTAG
|
Protein Properties |
Number of Residues
| 1785 |
Molecular Weight
| 202036.5 |
Theoretical pI
| 6.28 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Brefeldin A-inhibited guanine nucleotide-exchange protein 2
MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKA
NFIEADKYFLPFELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVE
TICSCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQT
TAKATLTQMLNVIFTRMENQVLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQS
KPTTPEKTDLTNGEHARSDSGKVSTENGDAPRERGSSLSGTDDGAQEVVKDILEDVVTSA
IKEAAEKHGLTEPERVLGELECQECAIPPGVDENSQTNGIADDRQSLSSADNLESDAQGH
QVAARFSHVLQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGP
VFRTHEMFINAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKE
IFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKI
AQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQTSLGQERLTDQE
IGDGKGLDMARRCSVTSMESTVSSGTQTTVQDDPEQFEVIKQQKEIIEHGIELFNKKPKR
GIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEK
EFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLT
TDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKETKELTIATK
STKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTP
LLAAYSIGLQNCDDTEVASLCLEGIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSI
TEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRYLSGSGRE
REGSLKGHTLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGST
RLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGD
HFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIR
DMAIRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHF
PAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAP
GDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFEKHWWQDLFRIVFR
IFDNMKLPEQLSEKSEWMTTTCNHALYAICDVFTQFYEALNEVLLSDVFAQLQWCVKQDN
EQLARSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGMEEDSSE
KHLDVDLDRQSLSSIDKNPSERGQSQLSNPTDDSWKGRPYANQKLFASLLIKCVVQLELI
QTIDNIVFYPATSKKEDAEHMVAAQQDTLDADIHIETEDQGMYKYMSSQHLFKLLDCLQE
SHSFSKAFNSNYEQRTVLWRAGFKGKSKPNLLKQETSSLACCLRILFRMYVDENRRDSWE
EIQQRLLTVCSEALAYFITVNSESHREAWTSLLLLLLTKTLKINDEKFKAHASMYYPYLC
EIMQFDLIPELRAVLRKFFLRIGVVYKIWIPEEPSQVPAALSPVW
|
External Links |
GenBank ID Protein
| 5052123 |
UniProtKB/Swiss-Prot ID
| Q9Y6D5 |
UniProtKB/Swiss-Prot Entry Name
| BIG2_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AF084521 |
GeneCard ID
| ARFGEF2 |
GenAtlas ID
| ARFGEF2 |
HGNC ID
| HGNC:15853 |
References |
General References
| Not Available |