| Identification |
|---|
| HMDB Protein ID
| CDBP03531 |
| Secondary Accession Numbers
| Not Available |
| Name
| Brefeldin A-inhibited guanine nucleotide-exchange protein 1 |
| Description
| Not Available |
| Synonyms
|
- Brefeldin A-inhibited GEP 1
- p200 ARF guanine nucleotide exchange factor
- p200 ARF-GEP1
|
| Gene Name
| ARFGEF1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP |
| GO Classification
|
| Component |
| intracellular |
| cell part |
| Function |
| small gtpase regulator activity |
| binding |
| enzyme regulator activity |
| arf guanyl-nucleotide exchange factor activity |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| Process |
| regulation of ras protein signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of arf protein signal transduction |
| regulation of cellular process |
| regulation of cell communication |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:8 |
| Locus
| 8q13 |
| SNPs
| ARFGEF1 |
| Gene Sequence
|
>5550 bp
ATGTATGAGGGGAAGAAGACGAAGAACATGTTCCTGACCCGGGCTCTGGAGAAGATATTG
GCCGACAAGGAAGTGAAGAAGGCGCATCACTCCCAGCTGCGCAAAGCTTGCGAGGTGGCG
TTAGAGGAAATAAAAGCGGAAACTGAAAAACAGAGTCCTCCTCATGGAGAAGCAAAAGCT
GGATCAAGCACCCTTCCACCAGTGAAATCAAAGACAAATTTTATTGAAGCAGACAAGTAC
TTCTTGCCTTTTGAGTTGGCATGCCAGTCCAAATGTCCTCGCATAGTTAGTACATCTCTA
GATTGCTTACAGAAACTTATTGCTTATGGGCACTTGACTGGCAATGCTCCAGATAGTACA
ACACCAGGCAAAAAATTAATTGATAGAATTATTGAAACAATATGTGGCTGCTTTCAGGGC
CCTCAGACAGATGAAGGAGTTCAGCTGCAGATAATAAAGGCTTTACTTACTGCAGTAACA
TCACAACACATAGAAATTCATGAAGGGACTGTACTGCAAGCTGTGAGAACATGTTACAAT
ATCTACTTAGCAAGCAAAAATCTCATCAATCAGACAACAGCCAAAGCTACTCTCACTCAG
ATGCTAAATGTTATCTTTGCACGCATGGAAAACCAAGCATTACAGGAAGCAAAACAAATG
GAAAAAGAAAGGCATCGGCAGCATCATCATCTGTTACCGTCTCCAGTAAGCCATCACGAG
CCTGAATCACCTCAACTTAGATATTTGCCACCTCAGACTGTTGATCATATATCCCAAGAA
CACGAAGGGGACCTTGACCTCCATACAAATGATGTAGATAAAAGTCTTCAGGATGACACA
GAGCCTGAAAATGGATCTGATATTTCCAGTGCAGAAAATGAACAGACTGAAGCTGATCAG
GCAACTGCAGCTGAAACATTATCTAAAAATGAAGTGTTATATGACGGAGAAAACCATGAT
TGTGAGGAAAAGCCACAAGACATTGTACAGAACATTGTAGAAGAAATGGTGAACATTGTT
GTTGGAGATATGGGAGAAGGGACTACTATAAATGCAAGTGCAGATGGCAACATTGGAACT
ATAGAGGATGGTAGTGACAGTGAAAATATTCAAGCAAATGGAATTCCAGGAACACCAATT
TCTGTTGCATATACACCATCCTTACCTGATGATAGATTGTCAGTCTCTTCCAATGATACT
CAGGAATCTGGAAATTCTTCAGGACCTTCACCTGGTGCTAAGTTTTCCCACATTTTACAA
AAGGATGCCTTTCTAGTATTCAGGTCATTGTGTAAACTGTCAATGAAACCACTGTCAGAT
GGACCACCAGATCCAAAGTCTCATGAACTACGATCCAAGATTCTTTCATTGCAGTTACTT
CTATCCATTCTGCAGAATGCAGGACCTATTTTCAGGACAAATGAGATGTTTATTAATGCT
ATTAAGCAGTATCTTTGTGTTGCACTCTCAAAAAATGGAGTCTCATCTGTTCCAGAGGTT
TTTGAGCTTTCTCTTTCTATATTTCTTACTTTGTTGTCAAATTTCAAGACACATCTGAAG
ATGCAAATTGAGGTGTTCTTTAAAGAAATTTTCTTATACATTTTGGAAACTTCTACCAGC
TCATTTGATCACAAATGGATGGTTATTCAGACACTGACGAGGATTTGTGCAGATGCTCAG
AGTGTAGTGGATATTTATGTAAACTATGACTGTGACTTAAATGCAGCCAATATATTTGAA
AGACTAGTAAATGATCTATCAAAAATTGCTCAAGGAAGGGGCAGTCAAGAACTTGGTATG
AGTAATGTTCAGGAATTGAGCCTGAGGAAAAAAGGTTTAGAATGCTTAGTGTCGATTTCG
AAGTGTATGGTTGAATGGAGTAAGGATCAGTATGTGAATCCCAACTCCCAGACAACTCTT
GGTCAGGAAAAACCCTCAGAGCAAGAGATGAGTGAAATCAAACACCCTGAGACAATAAAC
AGATACGGAAGTTTAAATTCCCTGGAGTCAACATCATCATCAGGAATAGGCAGCTACAGT
ACACAGATGTCTGGCACTGATAATCCAGAACAATTTGAGGTCCTAAAGCAACAAAAAGAA
ATAATAGAACAAGGGATAGATTTATTTAATAAGAAACCAAAGAGAGGAATACAGTACCTC
CAAGAACAAGGGATGCTTGGCACCACACCTGAAGATATTGCCCAATTCTTACATCAAGAG
GAAAGATTAGACTCTACTCAAGTGGGTGAGTTCCTGGGAGATAATGATAAATTTAACAAA
GAAGTCATGTATGCATATGTGGACCAACATGACTTTTCAGGAAAAGACTTCGTTTCAGCC
CTTCGTATGTTTCTAGAAGGATTTCGTCTTCCAGGGGAAGCTCAGAAAATCGATCGATTA
ATGGAAAAATTTGCTGCAAGATACCTAGAATGCAACCAAGGACAAACTCTCTTTGCTAGT
GCGGATACAGCTTATGTTTTGGCTTATTCAATTATCATGTTGACCACAGACCTTCACAGT
CCACAGGTGAAAAATAAAATGACAAAGGAACAATACATTAAGATGAATAGAGGTATCAAT
GACAGTAAAGACCTTCCTGAAGAGTATCTATCAGCCATCTATAATGAAATAGCTGGGAAA
AAGATATCAATGAAAGAAACAAAAGAACTAACAATCCCTACAAAATCAAGTAAACAGAAT
GTAGCCAGTGAAAAACAAAGAAGACTTCTGTATAACTTAGAAATGGAGCAGATGGCCAAG
ACAGCTAAAGCACTCATGGAGGCCGTGAGCCATGTTCAGGCACCCTTTACAAGTGCAACA
CATTTGGAGCATGTGAGGCCCATGTTTAAGTTGGCTTGGACGCCTTTTCTGGCTGCATTC
AGTGTGGGTCTACAAGATTGTGATGATACTGAAGTAGCCTCTCTTTGCCTGGAAGGTATA
AGATGTGCAATCAGAATTGCATGCATTTTCAGCATTCAGCTGGAGAGAGATGCATATGTC
CAGGCACTAGCAAGATTTACCTTACTCACAGTGAGTTCCGGTATTACTGAAATGAAACAG
AAGAACATTGACACAATAAAAACACTTATCACAGTGGCTCATACAGATGGAAATTATTTA
GGAAATTCATGGCATGAGATTCTGAAGTGCATCAGTCAGTTGAAGCTGGCACAGCTTATA
GGAACTGGAGTGAAACCTCGATACATTTCTGGAACAGTGCGAGGCAGAGAAGGATCTCTT
ACTGGAACAAAAGATCAGGCTCCTGATGAATTTGTGGGTTTAGGGCTAGTTGGAGGAAAT
GTGGACTGGAAACAGATAGCAAGTATTCAGGAATCCATTGGAGAAACCAGTTCTCAGAGT
GTTGTTGTTGCTGTAGATAGAATATTCACAGGATCTACAAGGCTAGATGGAAATGCCATT
GTGGATTTTGTCCGTTGGCTCTGTGCTGTGTCTATGGATGAATTACTTTCCACGACACAC
CCAAGAATGTTTAGTCTACAAAAAATAGTAGAAATATCATATTACAACATGGGAAGAATA
AGATTACAGTGGTCTCGAATTTGGGAAGTTATTGGAGATCATTTTAATAAGGTTGGGTGT
AATCCTAATGAAGATGTAGCTATTTTTGCAGTAGACTCCTTGAGGCAGTTGTCAATGAAG
TTCTTAGAGAAAGGGGAGCTTGCTAACTTCAGATTCCAGAAGGATTTCTTAAGACCTTTT
GAACATATAATGAAACGGAACAGGTCTCCAACAATTCGAGATATGGTTGTACGGTGTATA
GCACAGATGGTTAATTCTCAAGCTGCTAACATTCGATCTGGATGGAAGAACATTTTCTCT
GTATTTCATCTAGCTGCATCTGATCAAGATGAAAGCATAGTGGAACTTGCATTCCAAACA
ACCGGGCACATTGTCACCCTTGTATTTGAAAAACACTTTCCAGCGACCATTGATTCTTTC
CAGGATGCAGTGAAGTGTTTGTCTGAATTTGCGTGCAATGCAGCTTTCCCAGACACAAGT
ATGGAAGCAATTCGACTTATTCGCCATTGTGCAAAATATGTGTCTGATAGACCTCAGGCT
TTCAAGGAATACACAAGCGATGATATGAACGTAGCACCTGAAGACAGGGTGTGGGTGAGA
GGATGGTTCCCAATTCTCTTTGAGTTATCCTGTATCATCAATAGATGCAAATTAGATGTA
AGAACCAGGGGTTTAACAGTAATGTTTGAAATAATGAAAACATATGGCCACACTTATGAG
AAACACTGGTGGCAGGATTTATTTAGAATTGTTTTCAGAATCTTTGACAATATGAAATTG
CCAGAACAACAGACAGAGAAAGCTGAATGGATGACAACAACTTGCAATCATGCACTTTAT
GCAATCTGTGATGTATTCACTCAGTATTTAGAAGTACTCAGTGATGTACTTTTGGATGAC
ATTTTTGCTCAGCTCTACTGGTGTGTGCAGCAAGACAATGAGCAGTTAGCGCGATCTGGT
ACAAACTGTTTAGAGAATGTTGTTATTCTGAATGGTGAAAAATTTACCCTAGAAATCTGG
GATAAAACTTGCAACTGCACACTGGATATCTTCAAAACCACAATCCCACATGCGCTGTTG
ACCTGGCGACCCAATTCTGGAGAAACTGCCCCCCCACCTCCATCTCCTGTAAGTGAAAAG
CCATTGGATACAATATCACAGAAGTCTGTAGATATTCATGATTCTATTCAACCAAGGTCT
GTGGATAACAGACCACAAGCACCACTGGTTTCTGCGTCTGCTGTTAATGAAGAAGTCAGC
AAAATTAAATCTACAGCAAAATTTCCAGAACAAAAATTGTTTGCTGCCCTGTTGATTAAA
TGTGTTGTGCAGCTGGAACTCATCCAGACTATCGACAACATTGTCTTCTTCCCAGCCACA
AGTAAGAAAGAAGATGCAGAAAACTTAGCTGCAGCACAGAGAGATGCGGTGGACTTTGAT
GTTCGCGTTGATACTCAAGACCAAGGAATGTACCGCTTTTTAACATCACAACAACTTTTT
AAGCTACTGGACTGCTTATTAGAGTCACATAGATTTGCAAAAGCGTTTAATTCCAACAAC
GAACAGAGGACTGCCCTGTGGAAAGCAGGATTCAAAGGCAAATCCAAGCCCAACCTTCTG
AAGCAGGAGACCAGCAGCCTGGCCTGTGGGCTGCGCATTCTCTTCCGGATGTACATGGAT
GAGAGCCGCGTTAGTGCCTGGGAGGAGGTCCAGCAGAGGCTTTTGAATGTCTGCAGTGAA
GCACTAAGTTACTTCCTCACTCTAACATCAGAAAGTCATCGAGAAGCCTGGACTAACTTA
CTGCTTTTGTTTCTAACTAAAGTTCTAAAGATAAGTGATAATAGGTTTAAAGCTCATGCA
TCATTCTACTACCCTCTCTTATGTGAAATTATGCAATTTGACTTGATTCCTGAACTTCGT
GCTGTTCTTAGAAGATTTTTTCTGCGAATCGGAGTAGTTTTTCAGATATCACAACCACCT
GAACAGGAACTTGGTATTAACAAACAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1849 |
| Molecular Weight
| 208765.2 |
| Theoretical pI
| 5.65 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Brefeldin A-inhibited guanine nucleotide-exchange protein 1
MYEGKKTKNMFLTRALEKILADKEVKKAHHSQLRKACEVALEEIKAETEKQSPPHGEAKA
GSSTLPPVKSKTNFIEADKYFLPFELACQSKCPRIVSTSLDCLQKLIAYGHLTGNAPDST
TPGKKLIDRIIETICGCFQGPQTDEGVQLQIIKALLTAVTSQHIEIHEGTVLQAVRTCYN
IYLASKNLINQTTAKATLTQMLNVIFARMENQALQEAKQMEKERHRQHHHLLQSPVSHHE
PESPQLRYLPPQTVDHISQEHEGDLDLHTNDVDKSLQDDTEPENGSDISSAENEQTEADQ
ATAAETLSKNEVLYDGENHDCEEKPQDIVQNIVEEMVNIVVGDMGEGTTINASADGNIGT
IEDGSDSENIQANGIPGTPISVAYTPSLPDDRLSVSSNDTQESGNSSGPSPGAKFSHILQ
KDAFLVFRSLCKLSMKPLSDGPPDPKSHELRSKILSLQLLLSILQNAGPIFRTNEMFINA
IKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILETSTS
SFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGM
SNVQELSLRKKGLECLVSILKCMVEWSKDQYVNPNSQTTLGQEKPSEQEMSEIKHPETIN
RYGSLNSLESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYL
QEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSA
LRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHS
PQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPTKSSKQN
VASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKLAWTPFLAAF
SVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGITEMKQ
KNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKPRYISGTVRGREGSL
TGTKDQAPDEFVGLGLVGGNVDWKQIASIQESIGETSSQSVVVAVDRIFTGSTRLDGNAI
VDFVRWLCAVSMDELLSTTHPRMFSLQKIVEISYYNMGRIRLQWSRIWEVIGDHFNKVGC
NPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKRNRSPTIRDMVVRCI
AQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQTTGHIVTLVFEKHFPATIDSF
QDAVKCLSEFACNAAFPDTSMEAIRLIRHCAKYVSDRPQAFKEYTSDDMNVAPEDRVWVR
GWFPILFELSCIINRCKLDVRTRGLTVMFEIMKTYGHTYEKHWWQDLFRIVFRIFDNMKL
PEQQTEKAEWMTTTCNHALYAICDVFTQYLEVLSDVLLDDIFAQLYWCVQQDNEQLARSG
TNCLENVVILNGEKFTLEIWDKTCNCTLDIFKTTIPHALLTWRPNSGETAPPPPSPVSEK
PLDTISQKSVDIHDSIQPRSVDNRPQAPLVSASAVNEEVSKIKSTAKFPEQKLFAALLIK
CVVQLELIQTIDNIVFFPATSKKEDAENLAAAQRDAVDFDVRVDTQDQGMYRFLTSQQLF
KLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSKPNLLKQETSSLACGLRILFRMYMD
ESRVSAWEEVQQRLLNVCSEALSYFLTLTSESHREAWTNLLLLFLTKVLKISDNRFKAHA
SFYYPLLCEIMQFDLIPELRAVLRRFFLRIGVVFQISQPPEQELGINKQ
|
| External Links |
|---|
| GenBank ID Protein
| 5052121 |
| UniProtKB/Swiss-Prot ID
| Q9Y6D6 |
| UniProtKB/Swiss-Prot Entry Name
| BIG1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF084520 |
| GeneCard ID
| ARFGEF1 |
| GenAtlas ID
| ARFGEF1 |
| HGNC ID
| HGNC:15772 |
| References |
|---|
| General References
| Not Available |