Cannabis Compound Database: Showing Protein ERO1-like protein beta (CDBP03484)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP03484

Secondary Accession Numbers

Not Available

Name

ERO1-like protein beta

Description

Not Available

Synonyms

ERO1-L-beta
Endoplasmic oxidoreductin-1-like protein B
Oxidoreductin-1-L-beta

Gene Name

ERO1LB

Protein Type

Enzyme

Biological Properties

General Function

Involved in protein binding

Specific Function

Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the being a source of oxidative stress. Required for the folding of cell, thereby being a source of oxidative stress

GO Classification

Component
membrane
cell part
endoplasmic reticulum membrane
organelle membrane
Function
oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
binding
catalytic activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
protein binding
oxidoreductase activity, acting on a sulfur group of donors
oxidoreductase activity
fad or fadh2 binding
Process
macromolecule metabolic process
cellular protein metabolic process
protein thiol-disulfide exchange
protein folding
oxidation reduction
protein metabolic process
metabolic process

Cellular Location

Peripheral membrane protein
Endoplasmic reticulum membrane
Lumenal side

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

1q42.2-q43

SNPs

ERO1LB

Gene Sequence

>1404 bp
ATGAGCCAAGGGGTCCGCCGGGCAGGCGCTGGGCAGGGGGTAGCGGCCGCGGTGCAGCTG
CTGGTCACCCTGAGCTTCCTGCGGAGCGTCGTCGAGGCGCAGGTCACTGGAGTTCTGGAT
GATTGCTTGTGTGATATTGACAGCATCGATAACTTCAATACCTACAAAATCTTCCCCAAA
ATAAAAAAATTGCAAGAGAGAGACTATTTTCGTTATTACAAGGTTAATCTGAAGCGACCT
TGTCCTTTCTGGGCAGAAGATGGCCACTGTTCAATAAAAGACTGTCATGTGGAGCCCTGT
CCAGAGAGTAAAATTCCGGTTGGAATAAAAGCTGGGCATTCTAATAAGTACTTGAAAATG
GCAAACAATACCAAAGAATTAGAAGATTGTGAGCAAGCTAATAAACTGGGAGCAATTAAC
AGCACATTAAGTAATCAAAGCAAAGAAGCTTTCATTGACTGGGCAAGATATGATGATTCA
CGGGATCACTTTTGTGAACTTGATGATGAGAGATCTCCAGCTGCTCAGTATGTAGACCTA
TTGCTGAACCCAGAGCGTTACACTGGCTATAAAGGGACCTCTGCATGGAGAGTGTGGAAC
AGCATCTATGAAGAGAACTGTTTCAAGCCTCGATCTGTTTATCGTCCTTTAAATCCTCTG
GCGCCTAGCCGAGGCGAAGATGATGGAGAATCATTCTACACATGGCTAGAAGGTTTGTGT
CTGGAGAAAAGAGTCTTCTATAAGCTTATATCGGGACTTCATGCTAGCATCAATTTACAT
CTATGCGCAAATTATCTTTTGGAAGAAACCTGGGGTAAGCCCAGTTGGGGACCTAATATT
AAAGAATTCAAACACCGCTTTGACCCTGTGGAAACCAAGGGAGAAGGTCCAAGAAGGCTC
AAGAATCTTTACTTTTTATACTTGATTGAGCTTCGAGCTTTGTCAAAGGTGGCTCCATAT
TTTGAGCGCTCAATTGTCGATCTTTACACTGGAAATGCAGAAGAAGATGCTGACACAAAA
ACTCTTCTACTGAATATCTTTCAAGATACAAAGTCCTTTCCCATGCACTTTGATGAGAAA
TCCATGTTTGCAGGTGACAAAAAAGGGGCCAAGTCACTAAAGGAGGAATTCCGATTACAT
TTCAAGAATATCTCCCGTATAATGGACTGTGTTGGATGTGACAAATGCAGATTATGGGGA
AAATTACAGACTCAGGGTTTAGGAACTGCCCTGAAGATATTATTCTCTGAAAAAGAAATC
CAAAAGCTTCCAGAGAATAGTCCATCTAAAGGCTTCCAACTCACCCGACAGGAAATAGTT
GCTCTTTTAAATGCTTTTGGAAGGCTTTCTACAAGTATAAGAGACTTACAGAATTTTAAA
GTCTTATTACAACAGAGTAGGTAA

Protein Properties

Number of Residues

467

Molecular Weight

53542.6

Theoretical pI

8.07

Pfam Domain Function

ERO1 (PF04137 )

Signals

["1-33"]

Transmembrane Regions

["None"]

Protein Sequence

>ERO1-like protein beta
MSQGVRRAGAGQGVAAAVQLLVTLSFLRSVVEAQVTGVLDDCLCDIDSIDNFNTYKIFPK
IKKLQERDYFRYYKVNLKRPCPFWAEDGHCSIKDCHVEPCPESKIPVGIKAGHSNKYLKM
ANNTKELEDCEQANKLGAINSTLSNQSKEAFIDWARYDDSRDHFCELDDERSPAAQYVDL
LLNPERYTGYKGTSAWRVWNSIYEENCFKPRSVYRPLNPLAPSRGEDDGESFYTWLEGLC
LEKRVFYKLISGLHASINLHLCANYLLEETWGKPSWGPNIKEFKHRFDPVETKGEGPRRL
KNLYFLYLIELRALSKVAPYFERSIVDLYTGNAEEDADTKTLLLNIFQDTKSFPMHFDEK
SMFAGDKKGAKSLKEEFRLHFKNISRIMDCVGCDKCRLWGKLQTQGLGTALKILFSEKEI
QKLPENSPSKGFQLTRQEIVALLNAFGRLSTSIRDLQNFKVLLQHSR

External Links

GenBank ID Protein

9716557

UniProtKB/Swiss-Prot ID

Q86YB8

UniProtKB/Swiss-Prot Entry Name

ERO1B_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF252538

GeneCard ID