Cannabis Compound Database: Showing Protein ERO1-like protein alpha (CDBP03483)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP03483

Secondary Accession Numbers

Not Available

Name

ERO1-like protein alpha

Description

Not Available

Synonyms

ERO1-L
ERO1-L-alpha
Endoplasmic oxidoreductin-1-like protein
Oxidoreductin-1-L-alpha

Gene Name

ERO1L

Protein Type

Enzyme

Biological Properties

General Function

Involved in protein binding

Specific Function

Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress. Required for the folding of immunoglobulin proteins. Responsible for the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin

GO Classification

Component
endoplasmic reticulum membrane
organelle membrane
membrane
cell part
Function
oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
binding
catalytic activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
protein binding
oxidoreductase activity, acting on a sulfur group of donors
oxidoreductase activity
fad or fadh2 binding
Process
protein folding
oxidation reduction
protein metabolic process
metabolic process
macromolecule metabolic process
cellular protein metabolic process
protein thiol-disulfide exchange

Cellular Location

Peripheral membrane protein
Endoplasmic reticulum membrane
Lumenal side

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

14q22.1

SNPs

ERO1L

Gene Sequence

>1407 bp
ATGGGCCGCGGCTGGGGATTCTTGTTTGGCCTCCTGGGCGCCGTGTGGCTGCTCAGCTCG
GGCCACGGAGAGGAGCAGCCCCCGGAGACAGCGGCACAGAGGTGCTTCTGCCAGGTTAGT
GGTTACTTGGATGATTGTACCTGTGATGTTGAAACCATTGATAGATTTAATAACTACAGG
CTTTTCCCAAGACTACAAAAACTTCTTGAAAGTGACTACTTTAGGTATTACAAGGTAAAC
CTGAAGAGGCCGTGTCCTTTCTGGAATGACATCAGCCAGTGTGGAAGAAGGGACTGTGCT
GTCAAACCATGTCAATCTGATGAAGTTCCTGATGGAATTAAATCTGCGAGCTACAAGTAT
TCTGAAGAAGCCAATAATCTCATTGAAGAATGTGAACAAGCTGAACGACTTGGAGCAGTG
GATGAATCTCTGAGTGAGGAAACACAGAAGGCTGTTCTTCAGTGGACCAAGCATGATGAT
TCTTCAGATAACTTCTGTGAAGCTGATGACATTCAGTCCCCTGAAGCTGAATATGTAGAT
TTGCTTCTTAATCCTGAGCGCTACACTGGTTACAAGGGACCAGATGCTTGGAAAATATGG
AATGTCATCTACGAAGAAAACTGTTTTAAGCCACAGACAATTAAAAGACCTTTAAATCCT
TTGGCTTCTGGTCAAGGGACAAGTGAAGAGAACACTTTTTACAGTTGGCTAGAAGGTCTC
TGTGTAGAAAAAAGAGCATTCTACAGACTTATATCTGGCCTACATGCAAGCATTAATGTG
CATTTGAGTGCAAGATATCTTTTACAAGAGACCTGGTTAGAAAAGAAATGGGGACACAAC
ATTACAGAATTTCAACAGCGATTTGATGGAATTTTGACTGAAGGAGAAGGTCCAAGAAGG
CTTAAGAACTTGTATTTTCTCTACTTAATAGAACTAAGGGCTTTATCCAAAGTGTTACCA
TTCTTCGAGCGCCCAGATTTTCAACTCTTTACTGGAAATAAAATTCAGGATGAGGAAAAC
AAAATGTTACTTCTGGAAATACTTCATGAAATCAAGTCATTTCCTTTGCATTTTGATGAG
AATTCATTTTTTGCTGGGGATAAAAAAGAAGCACACAAACTAAAGGAGGACTTTCGACTG
CATTTTAGAAATATTTCAAGAATTATGGATTGTGTTGGTTGTTTTAAATGTCGTCTGTGG
GGAAAGCTTCAGACTCAGGGTTTGGGCACTGCTCTGAAGATCTTATTTTCTGAGAAATTG
ATAGCAAATATGCCAGAAAGTGGACCTAGTTATGAATTCCATCTAACCAGACAAGAAATA
GTATCATTATTCAACGCATTTGGAAGAATTTCTACAAGTGTGAAAGAATTAGAAAACTTC
AGGAACTTGTTACAGAATATTCATTAA

Protein Properties

Number of Residues

468

Molecular Weight

54392.1

Theoretical pI

5.41

Pfam Domain Function

ERO1 (PF04137 )

Signals

["1-23"]

Transmembrane Regions

["None"]

Protein Sequence

>ERO1-like protein alpha
MGRGWGFLFGLLGAVWLLSSGHGEEQPPETAAQRCFCQVSGYLDDCTCDVETIDRFNNYR
LFPRLQKLLESDYFRYYKVNLKRPCPFWNDISQCGRRDCAVKPCQSDEVPDGIKSASYKY
SEEANNLIEECEQAERLGAVDESLSEETQKAVLQWTKHDDSSDNFCEADDIQSPEAEYVD
LLLNPERYTGYKGPDAWKIWNVIYEENCFKPQTIKRPLNPLASGQGTSEENTFYSWLEGL
CVEKRAFYRLISGLHASINVHLSARYLLQETWLEKKWGHNITEFQQRFDGILTEGEGPRR
LKNLYFLYLIELRALSKVLPFFERPDFQLFTGNKIQDEENKMLLLEILHEIKSFPLHFDE
NSFFAGDKKEAHKLKEDFRLHFRNISRIMDCVGCFKCRLWGKLQTQGLGTALKILFSEKL
IANMPESGPSYEFHLTRQEIVSLFNAFGRISTSVKELENFRNLLQNIH

External Links

GenBank ID Protein

7021226

UniProtKB/Swiss-Prot ID

Q96HE7

UniProtKB/Swiss-Prot Entry Name

ERO1A_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF081886

GeneCard ID