| Identification |
|---|
| HMDB Protein ID
| CDBP03475 |
| Secondary Accession Numbers
| Not Available |
| Name
| Apoptosis-inducing factor 2 |
| Description
| Not Available |
| Synonyms
|
- Apoptosis-inducing factor homologous mitochondrion-associated inducer of death
- Apoptosis-inducing factor-like mitochondrion-associated inducer of death
- p53-responsive gene 3 protein
|
| Gene Name
| AIFM2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Oxidoreductase, which may play a role in mediating a TP53/p53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest |
| GO Classification
|
| Function |
| oxidoreductase activity |
| fad or fadh2 binding |
| binding |
| catalytic activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Cytoplasm
- Mitochondrion outer membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 10q22.1 |
| SNPs
| AIFM2 |
| Gene Sequence
|
>1122 bp
ATGGGGTCCCAGGTCTCGGTGGAATCGGGAGCTCTGCACGTGGTGATTGTGGGTGGGGGC
TTTGGCGGGATCGCAGCAGCCAGCCAGCTGCAGGCCCTGAACGTCCCCTTCATGCTGGTG
GACATGAAGGACTCCTTCCACCACAATGTGGCTGCTCTCCGAGCCTCCGTGGAGACAGGG
TTCGCCAAAAAGACATTCATTTCTTACTCGGTGACTTTCAAGGACAACTTCCGGCAGGGG
CTAGTAGTGGGGATAGACCTGAAGAACCAGATGGTGCTGCTGCAGGGTGGCGAGGCCCTG
CCCTTCTCTCATCTTATCCTGGCCACGGGCAGCACTGGGCCCTTCCCGGGCAAGTTTAAT
GAGGTTTCCAGCCAGCAGGCCGCTATCCAGGCCTATGAGGACATGGTGAGGCAGGTCCAG
CGCTCACGGTTCATCGTGGTGGTGGGAGGAGGCTCGGCTGGAGTGGAGATGGCAGCAGAG
ATTAAAACAGAATATCCTGAGAAAGAGGTCACTCTCATTCACTCCCAAGTGGCCCTGGCT
GACAAGGAGCTCCTGCCCTCCGTCCGGCAGGAAGTGAAGGAGATCCTCCTCCGGAAGGGC
GTGCAGCTGCTGCTGAGTGAGCGGGTGAGCAATCTGGAGGAGCTGCCTCTCAATGAGTAT
CGAGAGTACATCAAAGTGCAGACGGACAAAGGCACAGAGGTGGCCACCAACCTGGTGATT
CTCTGCACCGGCATCAAGATCAACAGCTCCGCCTACCGCAAAGCATTTGAGAGCAGACTA
GCCAGCAGTGGTGCTCTGAGAGTGAACGAGCACCTCCAGGTGGAGGGCCACAGCAACGTC
TACGCCATTGGTGACTGTGCCGACGTGAGGACGCCCAAGATGGCCTATCTTGCCGGCCTC
CACGCCAACATCGCCGTGGCCAACATCGTCAACTCTGTGAAGCAGCGGCCTCTCCAGGCC
TACAAGCCGGGTGCACTGACGTTCCTCCTGTCCATGGGGAGAAATGACGGTGTGGGCCAA
ATCAGTGGCTTCTATGTGGGCCGGCTCATGGTTCGGCTGACCAAGAGCCGGGACCTGTTC
GTCTCTACGAGCTGGAAAACCATGAGGCAGTCTCCACCTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 373 |
| Molecular Weight
| 40526.4 |
| Theoretical pI
| 9.55 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Apoptosis-inducing factor 2
MGSQVSVESGALHVVIVGGGFGGIAAASQLQALNVPFMLVDMKDSFHHNVAALRASVETG
FAKKTFISYSVTFKDNFRQGLVVGIDLKNQMVLLQGGEALPFSHLILATGSTGPFPGKFN
EVSSQQAAIQAYEDMVRQVQRSRFIVVVGGGSAGVEMAAEIKTEYPEKEVTLIHSQVALA
DKELLPSVRQEVKEILLRKGVQLLLSERVSNLEELPLNEYREYIKVQTDKGTEVATNLVI
LCTGIKINSSAYRKAFESRLASSGALRVNEHLQVEGHSNVYAIGDCADVRTPKMAYLAGL
HANIAVANIVNSVKQRPLQAYKPGALTFLLSMGRNDGVGQISGFYVGRLMVRLTKSRDLF
VSTSWKTMRQSPP
|
| External Links |
|---|
| GenBank ID Protein
| 18478646 |
| UniProtKB/Swiss-Prot ID
| Q9BRQ8 |
| UniProtKB/Swiss-Prot Entry Name
| AIFM2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF337957 |
| GeneCard ID
| AIFM2 |
| GenAtlas ID
| AIFM2 |
| HGNC ID
| HGNC:21411 |
| References |
|---|
| General References
| Not Available |