| Identification |
|---|
| HMDB Protein ID
| CDBP03450 |
| Secondary Accession Numbers
| Not Available |
| Name
| U8 snoRNA-decapping enzyme |
| Description
| Not Available |
| Synonyms
|
- Nucleoside diphosphate-linked moiety X motif 16
- Nudix motif 16
- U8 snoRNA-binding protein H29K
- m7GpppN-mRNA hydrolase
|
| Gene Name
| NUDT16 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity |
| Specific Function
| RNA-decapping enzyme that binds specifically to U8 snoRNA. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and m227G caps from U8 snoRNA. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species (in vitro).
|
| GO Classification
|
| Biological Process |
| mRNA catabolic process |
| adenosine to inosine editing |
| dITP catabolic process |
| IDP catabolic process |
| negative regulation of rRNA processing |
| positive regulation of cell cycle process |
| positive regulation of double-strand break repair |
| snoRNA catabolic process |
| XDP catabolic process |
| positive regulation of cell proliferation |
| Cellular Component |
| cytoplasm |
| nucleolus |
| nucleoplasm |
| Function |
| catalytic activity |
| hydrolase activity |
| Molecular Function |
| GTP binding |
| dITP diphosphatase activity |
| mRNA binding |
| nucleotide phosphatase activity |
| m7G(5')pppN diphosphatase activity |
| cobalt ion binding |
| ITP binding |
| XTP binding |
| manganese ion binding |
| magnesium ion binding |
| snoRNA binding |
| metalloexopeptidase activity |
| protein homodimerization activity |
|
| Cellular Location
|
- Nucleus
- Nucleus
- nucleolus
- nucleoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | RNA degradation | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| 3q22.1 |
| SNPs
| NUDT16 |
| Gene Sequence
|
>588 bp
ATGGCCGGAGCCCGCAGGCTGGAGCTAGGCGAGGCCCTGGCGCTGGGGTCGGGCTGGCGT
CATGCGTGCCACGCTCTCCTCTACGCGCCGGACCCTGGGATGCTCTTCGGCCGCATCCCG
CTGCGCTACGCCATACTGATGCAGATGCGCTTCGATGGACGCCTGGGCTTCCCCGGCGGA
TTCGTGGACACGCAGGACAGAAGCCTAGAGGACGGGCTGAACCGCGAGCTGCGCGAGGAG
CTGGGCGAAGCGGCTGCCGCTTTCCGCGTGGAGCGCACTGACTACCGCAGCTCCCACGTC
GGGTCAGGGCCACGCGTTGTGGCCCACTTCTATGCCAAGCGTCTGACGCTCGAGGAGCTG
TTGGCTGTGGAGGCCGGCGCAACACGCGCCAAGGACCACGGGCTGGAGGTGCTGGGCCTG
GTGCGAGTGCCCCTGTATACCCTGCGGGATGGTGTAGGAGGCCTGCCTACCTTCCTGGAG
AATTCCTTTATTGGCTCTGCGCGGGAGCAGTTACTTGAAGCTCTCCAGGACTTGGGACTG
CTGCAGTCTGGCTCTATTTCAGGCCTTAAGATTCCAGCTCATCACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 195 |
| Molecular Weight
| 21273.13 |
| Theoretical pI
| 6.89 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>U8 snoRNA-decapping enzyme
MAGARRLELGEALALGSGWRHACHALLYAPDPGMLFGRIPLRYAILMQMRFDGRLGFPGG
FVDTQDRSLEDGLNRELREELGEAAAAFRVERTDYRSSHVGSGPRVVAHFYAKRLTLEEL
LAVEAGATRAKDHGLEVLGLVRVPLYTLRDGVGGLPTFLENSFIGSAREQLLEALQDLGL
LQSGSISGLKIPAHH
|
| External Links |
|---|
| GenBank ID Protein
| 285026434 |
| UniProtKB/Swiss-Prot ID
| Q96DE0 |
| UniProtKB/Swiss-Prot Entry Name
| NUD16_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_152395.2 |
| GeneCard ID
| NUDT16 |
| GenAtlas ID
| NUDT16 |
| HGNC ID
| HGNC:26442 |
| References |
|---|
| General References
| Not Available |