| Identification |
|---|
| HMDB Protein ID
| CDBP03438 |
| Secondary Accession Numbers
| Not Available |
| Name
| Na(+)/H(+) exchange regulatory cofactor NHE-RF3 |
| Description
| Not Available |
| Synonyms
|
- CFTR-associated protein of 70 kDa
- NHERF-3
- Na(+)/H(+) exchanger regulatory factor 3
- Na/Pi cotransporter C-terminal-associated protein 1
- NaPi-Cap1
- PDZ domain-containing protein 1
- Sodium-hydrogen exchanger regulatory factor 3
|
| Gene Name
| PDZK1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function |
| GO Classification
|
| Function |
| binding |
| protein binding |
|
| Cellular Location
|
- Cytoplasm
- Peripheral membrane protein
- Membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q21 |
| SNPs
| PDZK1 |
| Gene Sequence
|
>1560 bp
ATGACCTCCACCTTCAACCCCCGAGAATGTAAACTGTCCAAGCAAGAAGGGCAAAACTAT
GGCTTCTTCCTGCGAATTGAGAAGGACACCGAGGGCCACCTGGTCCGGGTGGTTGAGAAG
TGTAGCCCAGCAGAGAAGGCTGGCCTTCAAGATGGAGACAGAGTTCTTAGGATCAATGGT
GTCTTTGTGGACAAAGAAGAACATATGCAGGTTGTGGATCTGGTCAGAAAGAGTGGGAAT
TCAGTGACTTTACTAGTTCTGGATGGGGATTCCTATGAGAAAGCAGTGAAAACACGGGTG
GACTTGAAAGAGTTGGGTCAAAGTCAGAAGGAGCAAGGTTTGAGTGATAATATACTTTCC
CCTGTGATGAATGGAGGTGTGCAAACTTGGACCCAGCCCCGGCTCTGCTATCTCGTGAAG
GAAGGAGGCAGCTATGGCTTCTCTCTGAAAACTGTCCAAGGTAAAAAGGGGGTGTACATG
ACTGATATTACACCTCAAGGTGTGGCTATGAGAGCTGGAGTTCTGGCTGATGATCACTTG
ATTGAAGTGAATGGAGAGAATGTAGAGGATGCCAGCCATGAGAAAGTGGTTGAAAAGGTG
AAGAAGTCAGGAAGCCGTGTCATGTTCCTGCTGGTGGACAAAGAAACTGACAAGCGTCAT
GTTGAGCAGAAGATACAATTCAAAAGAGAAACAGCCAGTTTGAAACTGTTACCCCACCAG
CCCCGAATTGTGGAGATGAAGAAAGGAAGCAATGGCTATGGTTTCTATCTGAGGGCAGGC
TCAGAACAGAAAGGTCAAATCATCAAGGACATAGATTCTGGAAGTCCAGCAGAGGAGGCT
GGCTTGAAGAACAATGATCTGGTAGTTGCTGTCAACGGCGAGTCTGTGGAAACCCTGGAT
CATGACAGTGTGGTAGAAATGATTAGAAAGGGTGGAGATCAGACTTCACTGTTGGTGGTA
GACAAAGAGACGGACAACATGTACAGACTGGCTCATTTTTCTCCATTTCTCTACTATCAA
AGTCAAGAACTGCCCAATGGCTCTGTCAAGGAGGCTCCAGCTCCTACTCCCACTTCTCTG
GAAGTCTCAAGTCCACCAGATACTACAGAGGAAGTAGATCATAAGCCTAAACTCTGCAGG
CTGGCTAAAGGTGAAAATGGCTATGGCTTTCACTTAAATGCGATTCGGGGTCTGCCAGGC
TCATTCATCAAAGAGGTACAGAAGGGCGGTCCTGCTGACTTGGCTGGGCTAGAGGATGAG
GATGTCATCATTGAAGTGAATGGGGTGAATGTGCTAGATGAACCCTATGAGAAGGTGGTG
GATAGAATCCAGAGCAGTGGGAAGAATGTCACACTTCTAGTCTGTGGAAAGAAGGCCTAT
GATTATTTCCAAGCTAAGAAAATCCCTATTGTTTCCTCCCTGGCTGATCCACTTGACACC
CCTCCAGATTCTAAAGAAGGAATAGTGGTGGAGTCAAACCATGACTCGCACATGGCAAAA
GAACGGGCCCACAGTACAGCCTCACATTCTTCTTCCAATTCTGAAGATACAGAGATGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 519 |
| Molecular Weight
| 57129.0 |
| Theoretical pI
| 5.24 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Na(+)/H(+) exchange regulatory cofactor NHE-RF3
MTSTFNPRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRING
VFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRVDLKELGQSQKEQGLSDNILS
PVMNGGVQTWTQPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHL
IEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPHQ
PRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLD
HDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPTSL
EVSSPPDTTEEVDHKPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDE
DVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLVCGKKAYDYFQAKKIPIVSSLADPLDT
PPDSKEGIVVESNHDSHMAKERAHSTASHSSSNSEDTEM
|
| External Links |
|---|
| GenBank ID Protein
| 2944189 |
| UniProtKB/Swiss-Prot ID
| Q5T2W1 |
| UniProtKB/Swiss-Prot Entry Name
| NHRF3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF012281 |
| GeneCard ID
| PDZK1 |
| GenAtlas ID
| PDZK1 |
| HGNC ID
| HGNC:8821 |
| References |
|---|
| General References
| Not Available |