| Identification |
|---|
| HMDB Protein ID
| CDBP03435 |
| Secondary Accession Numbers
| Not Available |
| Name
| Methylosome subunit pICln |
| Description
| Not Available |
| Synonyms
|
- Chloride channel, nucleotide sensitive 1A
- Chloride conductance regulatory protein ICln
- Chloride ion current inducer protein
- ClCI
- I(Cln)
- Reticulocyte pICln
|
| Gene Name
| CLNS1A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in chloride transport |
| Specific Function
| The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway |
| GO Classification
|
| Process |
| cell volume homeostasis |
| chloride transport |
| anion transport |
| inorganic anion transport |
| cellular homeostasis |
| ion transport |
| establishment of localization |
| cellular process |
| transport |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
- Cytoplasm
- cytoskeleton
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11q13.5-q14 |
| SNPs
| CLNS1A |
| Gene Sequence
|
>714 bp
ATGAGCTTCCTCAAAAGTTTCCCGCCGCCTGGGCCAGCGGAGGGGCTCCTGCGGCAGCAG
CCAGACACTGAGGCTGTGCTGAACGGGAAGGGCCTCGGCACTGGTACCCTTTACATCGCT
GAGAGCCGCCTGTCTTGGTTAGATGGCTCTGGATTAGGATTCTCACTGGAATACCCCACC
ATTAGTTTACATGCATTATCCAGGGACCGAAGTGACTGTCTAGGAGAGCATTTGTATGTT
ATGGTGAATGCCAAATTTGAAGAAGAATCAAAAGAACCTGTTGCTGATGAAGAAGAGGAA
GACAGTGATGATGATGTTGAACCTATTACTGAATTTAGATTTGTGCCTAGTGATAAATCA
GCGTTGGAGGCAATGTTCACTGCAATGTGCGAATGCCAGGCCTTGCATCCAGATCCTGAG
GATGAGGATTCAGATGACTACGATGGAGAAGAATATGATGTGGAAGCACATGAACAAGGA
CAGGGGGACATCCCTACATTTTACACCTATGAAGAAGGATTATCCCATCTAACAGCAGAA
GGCCAAGCCACACTGGAGAGATTAGAAGGAATGCTTTCTCAGTCTGTGAGCAGCCAGTAT
AATATGGCTGGGGTCAGGACAGAAGATTCAATAAGAGATTATGAAGATGGGATGGAGGTG
GATACCACACCAACAGTTGCTGGACAGTTTGAGGATGCAGATGTTGATCACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 237 |
| Molecular Weight
| 26215.1 |
| Theoretical pI
| 3.72 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Methylosome subunit pICln
MSFLKSFPPPGPAEGLLRQQPDTEAVLNGKGLGTGTLYIAESRLSWLDGSGLGFSLEYPT
ISLHALSRDRSDCLGEHLYVMVNAKFEEESKEPVADEEEEDSDDDVEPITEFRFVPSDKS
ALEAMFTAMCECQALHPDPEDEDSDDYDGEEYDVEAHEQGQGDIPTFYTYEEGLSHLTAE
GQATLERLEGMLSQSVSSQYNMAGVRTEDSIRDYEDGMEVDTTPTVAGQFEDADVDH
|
| External Links |
|---|
| GenBank ID Protein
| 2209235 |
| UniProtKB/Swiss-Prot ID
| P54105 |
| UniProtKB/Swiss-Prot Entry Name
| ICLN_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF005422 |
| GeneCard ID
| CLNS1A |
| GenAtlas ID
| CLNS1A |
| HGNC ID
| HGNC:2080 |
| References |
|---|
| General References
| Not Available |