Identification
HMDB Protein ID CDBP03407
Secondary Accession Numbers Not Available
Name Chloride intracellular channel protein 4
Description Not Available
Synonyms
  1. Intracellular chloride ion channel protein p64H1
Gene Name CLIC4
Protein Type Transporter
Biological Properties
General Function Involved in voltage-gated chloride channel activity
Specific Function Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis)
GO Classification
Component
membrane
cell part
Function
voltage-gated chloride channel activity
anion channel activity
chloride channel activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
ion channel activity
Process
establishment of localization
transport
chloride transport
anion transport
inorganic anion transport
ion transport
Cellular Location
  1. Cell membrane
  2. Cytoplasm
  3. Mitochondrion
  4. cytoskeleton
  5. centrosome
  6. Cell junction
  7. Nucleus matrix
  8. Cytoplasmic vesicle membrane
  9. Single-pass membrane protein (Probable)
  10. Single-pass membrane protein (Probable)
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 1p36.11
SNPs CLIC4
Gene Sequence
>762 bp
ATGGCGTTGTCGATGCCGCTGAATGGGCTGAAGGAGGAGGACAAAGAGCCCCTCATCGAG
CTCTTCGTCAAGGCTGGCAGTGATGGTGAAAGCATAGGAAACTGCCCCTTTTCCCAGAGG
CTCTTCATGATTCTTTGGCTCAAAGGAGTTGTATTTAGTGTGACGACTGTTGACCTGAAA
AGGAAGCCAGCAGACCTGCAGAACTTGGCTCCCGGGACCCACCCACCATTTATAACTTTC
AACAGTGAAGTCAAAACGGATGTAAATAAGATTGAGGAATTTCTTGAAGAAGTCTTATGC
CCTCCCAAGTACTTAAAGCTTTCACCAAAACACCCAGAATCAAATACTGCTGGAATGGAC
ATCTTTGCCAAATTCTCTGCATATATCAAGAATTCAAGCGCAGAGGCTAATGAAGCACTG
GAGAGGGGTCTCCTGAAAACCCTGCAGAAACTGGATGAATATCTGAATTCTCCTCTCCCT
GATGAAATTGATGAAAATAGTATGGAGGACATAAAGTTTTCTACACGTAAATTTCTGGAT
GGCAATGAAATGACATTAGCTGATTGCAACCTGCTGCCCAAACTGCATATTGTCAAGGTG
GTGGCCAAAAAATATCGCAACTTTGATATTCCAAAAGAAATGACTGGCATCTGGAGATAC
CTAACTAATGCATACAGTAGGGACGAGTTCACCAATACCTGTCCCAGTGATAAGGAGGTT
GAAATAGCATATAGTGATGTAGCCAAAAGACTCACCAAGTAA
Protein Properties
Number of Residues 253
Molecular Weight 28771.8
Theoretical pI 5.26
Pfam Domain Function Not Available
Signals
  • ["None"]
Transmembrane Regions
  • ["37-57"]
Protein Sequence
>Chloride intracellular channel protein 4
MALSMPLNGLKEEDKEPLIELFVKAGSDGESIGNCPFSQRLFMILWLKGVVFSVTTVDLK
RKPADLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVLCPPKYLKLSPKHPESNTAGMD
IFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRKFLD
GNEMTLADCNLLPKLHIVKVVAKKYRNFDIPKEMTGIWRYLTNAYSRDEFTNTCPSDKEV
EIAYSDVAKRLTK
GenBank ID Protein 5052202
UniProtKB/Swiss-Prot ID Q9Y696
UniProtKB/Swiss-Prot Entry Name CLIC4_HUMAN
PDB IDs Not Available
GenBank Gene ID AF097330
GeneCard ID CLIC4
GenAtlas ID CLIC4
HGNC ID HGNC:13518
References
General References Not Available