Identification |
HMDB Protein ID
| CDBP03407 |
Secondary Accession Numbers
| Not Available |
Name
| Chloride intracellular channel protein 4 |
Description
| Not Available |
Synonyms
|
- Intracellular chloride ion channel protein p64H1
|
Gene Name
| CLIC4 |
Protein Type
| Transporter |
Biological Properties |
General Function
| Involved in voltage-gated chloride channel activity |
Specific Function
| Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis) |
GO Classification
|
Component |
membrane |
cell part |
Function |
voltage-gated chloride channel activity |
anion channel activity |
chloride channel activity |
transmembrane transporter activity |
substrate-specific transmembrane transporter activity |
ion transmembrane transporter activity |
transporter activity |
ion channel activity |
Process |
establishment of localization |
transport |
chloride transport |
anion transport |
inorganic anion transport |
ion transport |
|
Cellular Location
|
- Cell membrane
- Cytoplasm
- Mitochondrion
- cytoskeleton
- centrosome
- Cell junction
- Nucleus matrix
- Cytoplasmic vesicle membrane
- Single-pass membrane protein (Probable)
- Single-pass membrane protein (Probable)
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 1p36.11 |
SNPs
| CLIC4 |
Gene Sequence
|
>762 bp
ATGGCGTTGTCGATGCCGCTGAATGGGCTGAAGGAGGAGGACAAAGAGCCCCTCATCGAG
CTCTTCGTCAAGGCTGGCAGTGATGGTGAAAGCATAGGAAACTGCCCCTTTTCCCAGAGG
CTCTTCATGATTCTTTGGCTCAAAGGAGTTGTATTTAGTGTGACGACTGTTGACCTGAAA
AGGAAGCCAGCAGACCTGCAGAACTTGGCTCCCGGGACCCACCCACCATTTATAACTTTC
AACAGTGAAGTCAAAACGGATGTAAATAAGATTGAGGAATTTCTTGAAGAAGTCTTATGC
CCTCCCAAGTACTTAAAGCTTTCACCAAAACACCCAGAATCAAATACTGCTGGAATGGAC
ATCTTTGCCAAATTCTCTGCATATATCAAGAATTCAAGCGCAGAGGCTAATGAAGCACTG
GAGAGGGGTCTCCTGAAAACCCTGCAGAAACTGGATGAATATCTGAATTCTCCTCTCCCT
GATGAAATTGATGAAAATAGTATGGAGGACATAAAGTTTTCTACACGTAAATTTCTGGAT
GGCAATGAAATGACATTAGCTGATTGCAACCTGCTGCCCAAACTGCATATTGTCAAGGTG
GTGGCCAAAAAATATCGCAACTTTGATATTCCAAAAGAAATGACTGGCATCTGGAGATAC
CTAACTAATGCATACAGTAGGGACGAGTTCACCAATACCTGTCCCAGTGATAAGGAGGTT
GAAATAGCATATAGTGATGTAGCCAAAAGACTCACCAAGTAA
|
Protein Properties |
Number of Residues
| 253 |
Molecular Weight
| 28771.8 |
Theoretical pI
| 5.26 |
Pfam Domain Function
|
Not Available |
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Chloride intracellular channel protein 4
MALSMPLNGLKEEDKEPLIELFVKAGSDGESIGNCPFSQRLFMILWLKGVVFSVTTVDLK
RKPADLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVLCPPKYLKLSPKHPESNTAGMD
IFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRKFLD
GNEMTLADCNLLPKLHIVKVVAKKYRNFDIPKEMTGIWRYLTNAYSRDEFTNTCPSDKEV
EIAYSDVAKRLTK
|
External Links |
GenBank ID Protein
| 5052202 |
UniProtKB/Swiss-Prot ID
| Q9Y696 |
UniProtKB/Swiss-Prot Entry Name
| CLIC4_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AF097330 |
GeneCard ID
| CLIC4 |
GenAtlas ID
| CLIC4 |
HGNC ID
| HGNC:13518 |
References |
General References
| Not Available |