Identification |
HMDB Protein ID
| CDBP03405 |
Secondary Accession Numbers
| Not Available |
Name
| Chloride intracellular channel protein 2 |
Description
| Not Available |
Synonyms
|
- XAP121
|
Gene Name
| CLIC2 |
Protein Type
| Transporter |
Biological Properties |
General Function
| Involved in electron carrier activity |
Specific Function
| Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx |
GO Classification
|
Component |
membrane |
cell part |
Function |
transporter activity |
ion channel activity |
voltage-gated chloride channel activity |
catalytic activity |
electron carrier activity |
anion channel activity |
chloride channel activity |
oxidoreductase activity, acting on a sulfur group of donors |
disulfide oxidoreductase activity |
protein disulfide oxidoreductase activity |
transmembrane transporter activity |
substrate-specific transmembrane transporter activity |
ion transmembrane transporter activity |
oxidoreductase activity |
Process |
establishment of localization |
cellular process |
transport |
chloride transport |
anion transport |
inorganic anion transport |
cellular homeostasis |
cell redox homeostasis |
ion transport |
|
Cellular Location
|
- Cytoplasm
- Membrane
- Single-pass membrane protein (Probable)
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Gastric Acid Production | | Not Available | Esomeprazole Action Pathway | | Not Available | Omeprazole Action Pathway | | Not Available | Lansoprazole Action Pathway | | Not Available | Pantoprazole Action Pathway | | Not Available |
|
Gene Properties |
Chromosome Location
| Not Available |
Locus
| Not Available |
SNPs
| CLIC2 |
Gene Sequence
|
>744 bp
ATGTCAGGCCTGCGGCCCGGCACTCAAGTGGACCCTGAGATTGAGCTTTTTGTAAAGGCT
GGAAGTGATGGAGAGAGTATTGGAAACTGTCCCTTTTGCCAACGCCTTTTCATGATCCTC
TGGCTTAAAGGAGTTAAATTTAATGTGACAACTGTTGACATGACCAGAAAGCCTGAAGAA
CTAAAGGACTTAGCCCCAGGTACCAATCCTCCGTTCCTGGTGTATAACAAGGAGTTGAAA
ACAGACTTCATTAAAATTGAGGAGTTTTTAGAACAAACCCTGGCTCCTCCAAGGTACCCT
CACCTGAGTCCCAAGTACAAGGAGTCTTTTGATGTGGGCTGTAACCTCTTTGCCAAGTTT
TCTGCATACATTAAGAATACACAAAAGGAGGCAAATAAGAATTTTGAAAAATCTCTGCTC
AAAGAATTCAAGCGTCTGGATGACTACTTAAACACCCCACTTCTGGATGAAATTGATCCA
GACAGTGCTGAGGAACCCCCAGTTTCCAGAAGACTATTCTTGGATGGGGACCAGCTAACA
CTGGCTGATTGTAGCTTGTTACCCAAGCTGAACATTATTAAAGTTGCTGCCAAGAAATAT
CGTGACTTTGACATTCCAGCAGAATTCTCAGGAGTCTGGCGTTATCTCCACAATGCCTAT
GCCCGTGAAGAATTTACCCACACGTGTCCTGAAGACAAAGAAATTGAAAATACTTACGCA
AATGTGGCTAAACAGAAGAGTTAG
|
Protein Properties |
Number of Residues
| 247 |
Molecular Weight
| 28356.1 |
Theoretical pI
| 5.26 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Chloride intracellular channel protein 2
MSGLRPGTQVDPEIELFVKAGSDGESIGNCPFCQRLFMILWLKGVKFNVTTVDMTRKPEE
LKDLAPGTNPPFLVYNKELKTDFIKIEEFLEQTLAPPRYPHLSPKYKESFDVGCNLFAKF
SAYIKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLT
LADCSLLPKLNIIKVAAKKYRDFDIPAEFSGVWRYLHNAYAREEFTHTCPEDKEIENTYA
NVAKQKS
|
External Links |
GenBank ID Protein
| 66346733 |
UniProtKB/Swiss-Prot ID
| O15247 |
UniProtKB/Swiss-Prot Entry Name
| CLIC2_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| NM_001289.4 |
GeneCard ID
| CLIC2 |
GenAtlas ID
| CLIC2 |
HGNC ID
| HGNC:2063 |
References |
General References
| Not Available |