Cannabis Compound Database: Showing Protein H(+)/Cl(-) exchange transporter 3 (CDBP03399)

Identification Biological properties Gene properties Protein properties External links References XML Show 0 compounds

Identification

HMDB Protein ID

CDBP03399

Secondary Accession Numbers

Not Available

Name

H(+)/Cl(-) exchange transporter 3

Description

Not Available

Synonyms

Chloride channel protein 3
Chloride transporter ClC-3
ClC-3

Gene Name

CLCN3

Protein Type

Transporter

Biological Properties

General Function

Involved in ion channel activity

Specific Function

Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.

GO Classification

Biological Process
endosomal lumen acidification
Cellular Component
Golgi apparatus
early endosome
early endosome membrane
vesicle membrane
late endosome
apical plasma membrane
transport vesicle membrane
late endosome membrane
integral to membrane
Golgi membrane
cell surface
Component
membrane
cell part
Function
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
ion channel activity
voltage-gated chloride channel activity
anion channel activity
chloride channel activity
transmembrane transporter activity
Molecular Function
ATP binding
PDZ domain binding
protein homodimerization activity
antiporter activity
voltage-gated chloride channel activity
protein heterodimerization activity
Process
ion transport
establishment of localization
transport
chloride transport
transmembrane transport
anion transport
inorganic anion transport

Cellular Location

Golgi apparatus membrane
Late endosome membrane
Multi-pass membrane protein
Multi-pass membrane protein
Multi-pass membrane protein
Multi-pass membrane protein
Early endosome membrane
Isoform 2:Membrane

Pathways

Not Available

Gene Properties

Chromosome Location

Locus

4q33

SNPs

CLCN3

Gene Sequence

>2457 bp
ATGGAGTCTGAGCAGCTGTTCCATAGAGGCTACTATAGAAACAGCTACAACAGTATAACA
AGTGCAAGTAGTGATGAGGAACTTTTAGATGGAGCAGGTGTTATTATGGACTTTCAAACA
TCTGAAGATGACAATTTATTAGATGGTGACACTGCAGTTGGAACTCATTATACAATGACA
AATGGAGGCAGCATTAACAGTTCTACACATTTACTGGATCTTTTGGATGAACCAATTCCA
GGTGTTGGTACATATGATGATTTCCATACTATTGATTGGGTGCGAGAAAAATGTAAAGAC
AGAGAAAGGCATAGACGGATCAACAGCAAAAAGAAAGAATCAGCATGGGAAATGACAAAA
AGTTTGTATGATGCGTGGTCAGGATGGCTAGTAGTAACACTAACAGGATTGGCATCAGGG
GCACTGGCCGGATTAATAGACATTGCTGCCGATTGGATGACTGACCTAAAGGAGGGCATT
TGCCTTAGTGCGTTGTGGTACAACCACGAACAGTGCTGTTGGGGATCTAATGAAACAACA
TTTGAAGAGAGGGATAAATGTCCACAGTGGAAAACATGGGCAGAATTAATCATAGGTCAA
GCAGAGGGTCCTGGTTCTTATATCATGAACTACATAATGTACATCTTCTGGGCCTTGAGT
TTTGCCTTTCTTGCAGTTTCCCTGGTAAAGGTATTTGCTCCATATGCCTGTGGCTCTGGA
ATTCCAGAGATTAAAACTATTTTAAGTGGATTCATCATCAGAGGTTACTTGGGAAAATGG
ACTTTAATGATTAAAACCATCACATTAGTCCTGGCTGTGGCATCAGGTTTGAGTTTAGGA
AAAGAAGGTCCCCTGGTACATGTTGCCTGTTGCTGCGGAAATATCTTTTCCTACCTCTTT
CCAAAGTATAGCACAAACGAAGCTAAAAAAAGGGAGGTGCTATCAGCTGCCTCAGCTGCA
GGGGTTTCTGTAGCTTTTGGTGCACCAATTGGAGGAGTTCTTTTTAGCCTGGAAGAGGTT
AGCTATTATTTTCCTCTCAAAACTTTATGGAGATCATTTTTTGCTGCTTTAGTGGCTGCA
TTTGTTTTGAGGTCCATCAATCCATTTGGTAACAGCCGTCTGGTCCTTTTTTATGTGGAG
TATCATACACCATGGTACCTTTTTGAACTGTTTCCTTTTATTCTTCTAGGGGTATTTGGA
GGGCTTTGGGGAGCCTTTTTCATTAGGGCAAATATTGCCTGGTGTCGTCGACGCAAGTCC
ACGAAATTTGGAAAGTATCCCGTTCTGGAAGTCATTATTGTTGCAGCCATTACTGCTGTG
ATAGCCTTCCCTAATCCATACACTAGGCTAAACACCAGTGAACTGATCAAAGAGCTTTTT
ACAGACTGTGGTCCCCTGGAATCCTCTTCTCTTTGTGACTACAGAAATGACATGAATGCC
AGTAAAATTGTCGATGACATTCCTGATCGTCCAGCAGGCATTGGAGTATATTCAGCTATA
TGGCAGTTATGCCTGGCACTCATATTTAAAATCATAATGACAGTATTCACTTTTGGCATC
AAGGTTCCATCAGGCTTGTTCATCCCCAGCATGGCCATTGGAGCGATCGCAGGAAGGATT
GTGGGGATTGCGGTGGAGCAGCTTGCCTACTATCACCACGACTGGTTTATCTTTAAGGAG
TGGTGTGAGGTCGGGGCTGATTGCATTACACCTGGCCTTTATGCCATGGTTGGTGCTGCT
GCATGCTTAGGTGGTGTGACAAGAATGACTGTCTCCCTGGTGGTTATTGTTTTTGAGCTT
ACTGGAGGCTTGGAATATATTGTTCCCCTTATGGCTGCAGTCATGACCAGTAAATGGGTT
GGAGATGCCTTTGGCAGGGAAGGCATTTATGAAGCACACATCCGATTAAATGGATACCCT
TTCTTGGATGCAAAAGAAGAATTCACTCATACCACCCTGGCTGCTGACGTTATGAGACCT
CGAAGGAATGATCCTCCCTTAGCTGTCCTGACACAGGACAATATGACAGTGGATGATATA
GAAAACATGATTAATGAAACCAGCTACAATGGATTTCCTGTCATAATGTCAAAAGAATCT
CAGAGATTAGTGGGATTTGCCCTCAGAAGAGACCTGACAATTGCAATAGAAAGTGCCAGG
AAAAAACAAGAAGGTATCGTTGGCAGTTCTCGGGTGTGTTTTGCACAGCACACCCCATCT
CTTCCAGCAGAAAGTCCTCGGCCATTGAAGCTTCGAAGCATTCTTGACATGAGCCCTTTT
ACAGTGACAGACCACACCCCAATGGAGATCGTGGTGGATATTTTCCGAAAGCTGGGACTG
AGGCAGTGCCTTGTAACTCACAATGGGCGCCTCCTTGGCATTATAACAAAAAAAGATATC
CTCCGGCATATGGCCCAGACGGCAAACCAAGACCCCGCTTCAATAATGTTCAACTGA

Protein Properties

Number of Residues

818

Molecular Weight

88463.45

Theoretical pI

6.448

Pfam Domain Function

CBS (PF00571 )
Voltage_CLC (PF00654 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>H(+)/Cl(-) exchange transporter 3
MESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMT
NGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTK
SLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETT
FEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSG
IPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLF
PKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA
FVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKS
TKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNA
SKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRI
VGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFEL
TGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRP
RRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESAR
KKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGL
RQCLVTHNGRLLGIITKKDILRHMAQTANQDPASIMFN

External Links

GenBank ID Protein

55770838

UniProtKB/Swiss-Prot ID

P51790

UniProtKB/Swiss-Prot Entry Name

CLCN3_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_001829.2

GeneCard ID