Cannabis Compound Database: Showing Protein Dipeptidyl peptidase 1 (CDBP03394)

Identification Biological properties Gene properties Protein properties External links References XML Show 0 compounds

Identification

HMDB Protein ID

CDBP03394

Secondary Accession Numbers

Not Available

Name

Dipeptidyl peptidase 1

Description

Not Available

Synonyms

Cathepsin C
Cathepsin J
DPP-I
DPPI
Dipeptidyl peptidase 1 exclusion domain chain
Dipeptidyl peptidase 1 heavy chain
Dipeptidyl peptidase 1 light chain
Dipeptidyl peptidase I
Dipeptidyl peptidase I exclusion domain chain
Dipeptidyl peptidase I heavy chain
Dipeptidyl peptidase I light chain
Dipeptidyl transferase
SubName: Putative uncharacterized protein CTSC

Gene Name

CTSC

Protein Type

Enzyme

Biological Properties

General Function

Involved in cysteine-type endopeptidase activity

Specific Function

Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII

GO Classification

Function
cysteine-type peptidase activity
endopeptidase activity
cysteine-type endopeptidase activity
catalytic activity
hydrolase activity
peptidase activity
peptidase activity, acting on l-amino acid peptides
Process
metabolic process
macromolecule metabolic process
protein metabolic process
proteolysis

Cellular Location

Cytoplasmic
Lysosome

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

11q14.2

SNPs

CTSC

Gene Sequence

>1392 bp
ATGGGTGCTGGGCCCTCCTTGCTGCTCGCCGCCCTCCTGCTGCTTCTCTCCGGCGACGGC
GCCGTGCGCTGCGACACACCTGCCAACTGCACCTATCTTGACCTGCTGGGCACCTGGGTC
TTCCAGGTGGGCTCCAGCGGTTCCCAGCGCGATGTCAACTGCTCGGTTATGGGACCACAA
GAAAAAAAAGTAGTGGTGTACCTTCAGAAGCTGGATACAGCATATGATGACCTTGGCAAT
TCTGGCCATTTCACCATCATTTACAACCAAGGCTTTGAGATTGTGTTGAATGACTACAAG
TGGTTTGCCTTTTTTAAGTATAAAGAAGAGGGCAGCAAGGTGACCACTTACTGCAACGAG
ACAATGACTGGGTGGGTGCATGATGTGTTGGGCCGGAACTGGGCTTGTTTCACCGGAAAG
AAGGTGGGAACTGCCTCTGAGAATGTGTATGTCAACACAGCACACCTTAAGAATTCTCAG
GAAAAGTATTCTAATAGGCTCTACAAGTATGATCACAACTTTGTGAAAGCTATCAATGCC
ATTCAGAAGTCTTGGACTGCAACTACATACATGGAATATGAGACTCTTACCCTGGGAGAT
ATGATTAGGAGAAGTGGTGGCCACAGTCGAAAAATCCCAAGGCCCAAACCTGCACCACTG
ACTGCTGAAATACAGCAAAAGATTTTGCATTTGCCAACATCTTGGGACTGGAGAAATGTT
CATGGTATCAATTTTGTCAGTCCTGTTCGAAACCAAGCATCCTGTGGCAGCTGCTACTCA
TTTGCTTCTATGGGTATGCTAGAAGCGAGAATCCGTATACTAACCAACAATTCTCAGACC
CCAATCCTAAGCCCTCAGGAGGTTGTGTCTTGTAGCCAGTATGCTCAAGGCTGTGAAGGC
GGCTTCCCATACCTTATTGCAGGAAAGTACGCCCAAGATTTTGGGCTGGTGGAAGAAGCT
TGCTTCCCCTACACAGGCACTGATTCTCCATGCAAAATGAAGGAAGACTGCTTTCGTTAT
TACTCCTCTGAGTACCACTATGTAGGAGGTTTCTATGGAGGCTGCAATGAAGCCCTGATG
AAGCTTGAGTTGGTCCATCATGGGCCCATGGCAGTTGCTTTTGAAGTATATGATGACTTC
CTCCACTACAAAAAGGGGATCTACCACCACACTGGTCTAAGAGACCCTTTCAACCCCTTT
GAGCTGACTAATCATGCTGTTCTGCTTGTGGGCTATGGCACTGACTCAGCCTCTGGGATG
GATTACTGGATTGTTAAAAACAGCTGGGGCACCGGCTGGGGTGAGAATGGCTACTTCCGG
ATCCGCAGAGGAACTGATGAGTGTGCAATTGAGAGCATAGCAGTGGCAGCCACACCAATT
CCTAAATTGTAG

Protein Properties

Number of Residues

463

Molecular Weight

51841.4

Theoretical pI

6.99

Pfam Domain Function

Peptidase_C1 (PF00112 )
CathepsinC_exc (PF08773 )

Signals

["1-24"]

Transmembrane Regions

["None"]

Protein Sequence

>Dipeptidyl peptidase 1
MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQ
EKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNE
TMTGWVHDVLGRNWACFTGKKVGTASENVYVNTAHLKNSQEKYSNRLYKYDHNFVKAINA
IQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNV
HGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEG
GFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALM
KLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGM
DYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL

External Links

GenBank ID Protein

189083844

UniProtKB/Swiss-Prot ID

P53634

UniProtKB/Swiss-Prot Entry Name

CATC_HUMAN

PDB IDs