| Identification |
|---|
| HMDB Protein ID
| CDBP03386 |
| Secondary Accession Numbers
| Not Available |
| Name
| Relaxin receptor 2 |
| Description
| Not Available |
| Synonyms
|
- G-protein coupled receptor 106
- G-protein coupled receptor affecting testicular descent
- Leucine-rich repeat-containing G-protein coupled receptor 8
- Relaxin family peptide receptor 2
|
| Gene Name
| RXFP2 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) |
| GO Classification
|
| Component |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| membrane |
| cell part |
| Function |
| binding |
| receptor activity |
| transmembrane receptor activity |
| protein binding |
| molecular transducer activity |
| signal transducer activity |
| g-protein coupled receptor activity |
| Process |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
| signaling |
| signaling pathway |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 13q13.1 |
| SNPs
| RXFP2 |
| Gene Sequence
|
>2265 bp
ATGATTGTTTTTCTGGTTTTTAAACATCTCTTCAGCCTCAGATTGATTACAATGTTCTTT
CTACTTCATTTCATCGTTCTGATCAATGTCAAAGATTTTGCACTGACTCAAGGTAGCATG
ATCACTCCTTCATGCCAAAAAGGATATTTTCCCTGTGGGAATCTTACCAAGTGCTTACCC
CGAGCTTTTCACTGTGATGGCAAGGATGACTGTGGGAACGGGGCGGACGAAGAGAACTGT
GGTGACACTAGTGGATGGGCGACCATATTTGGCACAGTGCATGGAAATGCTAACAGCGTG
GCCTTAACACAGGAGTGCTTTCTAAAACAGTATCCACAATGCTGTGACTGCAAAGAAACT
GAATTGGAATGTGTAAATGGTGACTTAAAGTCTGTGCCGATGATTTCTAACAATGTGACA
TTACTGTCTCTTAAGAAAAACAAAATCCACAGTCTTCCAGATAAAGTTTTCATCAAATAC
ACAAAACTTAAAAAGATATTTCTTCAGCATAATTGCATTAGACACATATCCAGGAAAGCA
TTTTTTGGATTATGTAATCTGCAAATATTATATCTCAACCACAACTGCATCACAACCCTC
AGACCTGGAATATTCAAAGACTTACATCAGCTAACTTGGCTAATTCTAGATGACAATCCA
ATAACCAGAATTTCACAGCGCTTGTTTACGGGATTAAATTCCTTGTTTTTCCTGTCTATG
GTTAATAACTACTTAGAAGCTCTTCCCAAGCAGATGTGTGCCCAAATGCCTCAACTCAAC
TGGGTGGATTTGGAAGGCAATAGAATAAAGTATCTCACAAATTCTACGTTTCTGTCGTGC
GATTCGCTCACAGTGCTGTTTCTGCCTAGAAATCAAATTGGTTTTGTTCCAGAGAAGACA
TTTTCTTCATTAAAAAATTTAGGAGAACTGGATCTGTCTAGCAATACGATAACGGAGCTA
TCACCTCACCTTTTTAAAGACTTGAAGCTTCTACAAAAGCTGAACCTGTCATCCAATCCT
CTTATGTATCTTCACAAGAACCAGTTTGAAAGTCTTAAACAACTTCAGTCTCTAGACCTG
GAAAGGATAGAGATTCCAAATATAAACACACGAATGTTTCAACCCATGAAGAATCTTTCT
CACATTTATTTCAAAAACTTTCGATACTGCTCCTATGCTCCCCATGTCCGAATATGTATG
CCCTTGACGGACGGCATTTCTTCATTTGAGGACCTCTTGGCTAACAATATCCTCAGAATA
TTTGTCTGGGTTATAGCTTTCATTACCTGCTTTGGAAATCTTTTTGTCATTGGCATGAGA
TCTTTCATTAAAGCTGAAAATACAACTCACGCTATGTCCATCAAAATCCTTTGTTGTGCT
GATTGCCTGATGGGTGTTTACTTGTTCTTTGTTGGCATTTTCGATATAAAATACCGAGGG
CAGTATCAGAAGTATGCCTTGCTGTGGATGGAGAGCGTGCAGTGCCGCCTCATGGGGTTC
CTGGCCATGCTGTCCACCGAAGTCTCTGTTCTGCTACTGACCTACTTGACTTTGGAGAAG
TTCCTGGTCATTGTCTTCCCCTTCAGTAACATTCGACCTGGAAAACGGCAGACCTCAGTC
ATCCTCATTTGCATCTGGATGGCGGGATTTTTAATAGCTGTAATTCCATTTTGGAATAAG
GATTATTTTGGAAACTTTTATGGGAAAAATGGAGTATGTTTCCCACTTTATTATGACCAA
ACAGAAGATATTGGAAGCAAAGGGTATTCTCTTGGAATTTTCCTAGGTGTGAACTTGCTG
GCTTTTCTCATCATTGTGTTTTCCTATATTACTATGTTCTGTTCCATTCAAAAAACCGCC
TTGCAGACCACAGAAGTAAGGAATTGTTTTGGAAGAGAGGTGGCTGTTGCAAATCGTTTC
TTTTTTATAGTGTTCTCTGATGCCATCTGCTGGATTCCTGTATTTGTAGTTAAAATCCTT
TCCCTCTTCCGGGTGGAAATACCAGACACAATGACTTCCTGGATAGTGATTTTTTTCCTT
CCAGTTAACAGTGCTTTGAATCCAATCCTCTATACTCTCACAACCAACTTTTTTAAGGAC
AAGTTGAAACAGCTGCTGCACAAACATCAGAGGAAATCAATTTTCAAAATTAAAAAAAAA
AGTTTATCTACATCCATTGTGTGGATAGAGGACTCCTCTTCCCTGAAACTTGGGGTTTTG
AACAAAATAACACTTGGAGACAGTATAATGAAACCAGTTTCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 754 |
| Molecular Weight
| 86452.3 |
| Theoretical pI
| 8.92 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["417-437", "456-476", "496-518", "538-558", "593-613", "640-660", "671-691"]
|
| Protein Sequence
|
>Relaxin receptor 2
MIVFLVFKHLFSLRLITMFFLLHFIVLINVKDFALTQGSMITPSCQKGYFPCGNLTKCLP
RAFHCDGKDDCGNGADEENCGDTSGWATIFGTVHGNANSVALTQECFLKQYPQCCDCKET
ELECVNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKA
FFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSM
VNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKT
FSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDL
ERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYAPHVRICMPLTDGISSFEDLLANNILRI
FVWVIAFITCFGNLFVIGMRSFIKAENTTHAMSIKILCCADCLMGVYLFFVGIFDIKYRG
QYQKYALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFLVIVFPFSNIRPGKRQTSV
ILICIWMAGFLIAVIPFWNKDYFGNFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLL
AFLIIVFSYITMFCSIQKTALQTTEVRNCFGREVAVANRFFFIVFSDAICWIPVFVVKIL
SLFRVEIPDTMTSWIVIFFLPVNSALNPILYTLTTNFFKDKLKQLLHKHQRKSIFKIKKK
SLSTSIVWIEDSSSLKLGVLNKITLGDSIMKPVS
|
| External Links |
|---|
| GenBank ID Protein
| 18702460 |
| UniProtKB/Swiss-Prot ID
| Q8WXD0 |
| UniProtKB/Swiss-Prot Entry Name
| RXFP2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF403384 |
| GeneCard ID
| RXFP2 |
| GenAtlas ID
| RXFP2 |
| HGNC ID
| HGNC:17318 |
| References |
|---|
| General References
| Not Available |