Identification
HMDB Protein ID CDBP03375
Secondary Accession Numbers Not Available
Name Tyrosine-protein phosphatase non-receptor type 7
Description Not Available
Synonyms
  1. HEPTP
  2. Hematopoietic protein-tyrosine phosphatase
  3. Protein-tyrosine phosphatase LC-PTP
Gene Name PTPN7
Protein Type Receptor
Biological Properties
General Function Involved in phosphatase activity
Specific Function Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.
GO Classification
Cellular Component
cytosol
internal side of plasma membrane
Function
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
hydrolase activity, acting on ester bonds
Molecular Function
protein tyrosine phosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process
Cellular Location
  1. Cytoplasm
Pathways
Gene Properties
Chromosome Location 1
Locus 1q32.1
SNPs PTPN7
Gene Sequence
>1083 bp
ATGGTCCAAGCCCATGGGGGGCGCTCCAGAGCACAGCCGTTGACCTTGTCTTTGGGGGCA
GCCATGACCCAGCCTCCGCCTGAAAAAACGCCAGCCAAGAAGCATGTGCGACTGCAGGAG
AGGCGGGGCTCCAATGTGGCTCTGATGCTGGACGTTCGGTCCCTGGGGGCCGTAGAACCC
ATCTGCTCTGTGAACACACCCCGGGAGGTCACCCTACACTTTCTGCGCACTGCTGGACAC
CCCCTTACCCGCTGGGCCCTTCAGCGCCAGCCACCCAGCCCCAAGCAACTGGAAGAAGAA
TTCTTGAAGATCCCTTCAAACTTTGTCAGCCCCGAAGACCTGGACATCCCTGGCCACGCC
TCCAAGGACCGATACAAGACCATCTTGCCAAATCCCCAGAGCCGTGTCTGTCTAGGCCGG
GCACAGAGCCAGGAGGACGGAGATTACATCAATGCCAACTACATCCGAGGCTATGACGGG
AAGGAGAAGGTCTACATTGCCACCCAGGGCCCCATGCCCAACACTGTGTCGGACTTCTGG
GAGATGGTGTGGCAAGAGGAAGTGTCCCTCATTGTCATGCTCACTCAGCTCCGAGAGGGC
AAGGAGAAATGTGTCCACTACTGGCCCACAGAAGAGGAAACCTATGGACCCTTCCAGATC
CGCATCCAGGACATGAAAGAGTGCCCAGAATACACTGTGCGGCAGCTCACCATCCAGTAC
CAGGAAGAGCGCCGGTCAGTAAAGCACATCCTCTTTTCGGCCTGGCCAGACCATCAGACA
CCAGAATCAGCTGGGCCCCTGCTGCGCCTAGTGGCAGAGGTGGAGGAGAGCCCGGAGACA
GCCGCCCACCCCGGGCCTATCGTAGTCCACTGCAGTGCAGGGATTGGCCGGACGGGCTGC
TTCATCGCCACGCGAATTGGCTGTCAACAGCTGAAAGCCCGAGGAGAAGTGGACATTCTG
GGTATTGTGTGCCAACTGCGGCTAGACAGAGGGGGGATGATCCAGACGGCAGAGCAGTAC
CAGTTCCTGCACCACACTTTGGCCCTGTATGCAGGCCAGCTGCCTGAGGAACCCAGCCCC
TGA
Protein Properties
Number of Residues 360
Molecular Weight 45002.02
Theoretical pI 7.328
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Tyrosine-protein phosphatase non-receptor type 7
MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEP
ICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHA
SKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFW
EMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQY
QEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGC
FIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP
GenBank ID Protein 18375658
UniProtKB/Swiss-Prot ID P35236
UniProtKB/Swiss-Prot Entry Name PTN7_HUMAN
PDB IDs
GenBank Gene ID NM_002832.2
GeneCard ID PTPN7
GenAtlas ID PTPN7
HGNC ID HGNC:9659
References
General References Not Available